التفاصيل البيبلوغرافية
| العنوان: |
Amino acid supplementation confers protection to red blood cells prior to Plasmodium falciparum bystander stress. |
| المؤلفون: |
Binns HC, Alipour E, Nahid DS, Whitesides JF, Cox AO, Furdui CM, Marrs GS, Kim-Shapiro DB, Cordy RJ |
| المصدر: |
BioRxiv : the preprint server for biology [bioRxiv] 2023 May 16. Date of Electronic Publication: 2023 May 16. |
| نوع المنشور: |
Preprint |
| اللغة: |
English |
| بيانات الدورية: |
Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE |
| مستخلص: |
Malaria is a highly oxidative parasitic disease in which anemia is the most common clinical symptom. A major contributor to malarial anemia pathogenesis is the destruction of bystander, uninfected red blood cells. Metabolic fluctuations are known to occur in the plasma of individuals with acute malaria, emphasizing the role of metabolic changes in disease progression and severity. Here, we report that conditioned media from Plasmodium falciparum culture induces oxidative stress in healthy uninfected RBCs. Additionally, we show the benefit of amino acid pre-exposure for RBCs and how this pre-treatment intrinsically prepares RBCs to mitigate oxidative stress.
Key Points: Intracellular ROS is acquired in red blood cells incubated with Plasmodium falciparum conditioned media Glutamine, cysteine, and glycine amino acid supplementation increased glutathione biosynthesis and reduced ROS levels in stressed RBCs. |
| التعليقات: |
Update in: Blood Adv. 2024 Mar 27;:. (PMID: 38537079) |
| معلومات مُعتمدة: |
K01 HL143112 United States HL NHLBI NIH HHS; S10 OD032281 United States OD NIH HHS; T32 GM127261 United States GM NIGMS NIH HHS |
| تواريخ الأحداث: |
Date Created: 20230609 Latest Revision: 20240521 |
| رمز التحديث: |
20240521 |
| مُعرف محوري في PubMed: |
PMC10245693 |
| DOI: |
10.1101/2023.05.16.540951 |
| PMID: |
37292635 |
| قاعدة البيانات: |
MEDLINE |
