دورية أكاديمية
أعرض في EDS

Sex-associated early-life viral innate immune response is transcriptionally associated with chromatin remodeling of type-I IFN-inducible genes.

التفاصيل البيبلوغرافية
العنوان: Sex-associated early-life viral innate immune response is transcriptionally associated with chromatin remodeling of type-I IFN-inducible genes.
المؤلفون: Malinczak CA; Department of Pathology, University of Michigan, Ann Arbor, USA., Fonseca W; Department of Pathology, University of Michigan, Ann Arbor, USA., Mire MM; Department of Pathology, University of Michigan, Ann Arbor, USA., Parolia A; Department of Pathology, University of Michigan, Ann Arbor, USA; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, USA., Chinnaiyan A; Department of Pathology, University of Michigan, Ann Arbor, USA; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, USA; Howard Hughes Medical Institute, University of Michigan, Ann Arbor, USA., Rasky AJ; Department of Pathology, University of Michigan, Ann Arbor, USA., Morris S; Department of Pathology, University of Michigan, Ann Arbor, USA., Yagi K; Department of Pathology, University of Michigan, Ann Arbor, USA., Bermick JR; Department of Pediatrics, University of Iowa, Iowa City, USA., Lukacs NW; Department of Pathology, University of Michigan, Ann Arbor, USA; Mary H Weiser Food Allergy Center, University of Michigan, Ann Arbor, USA. Electronic address: nlukacs@umich.edu.
المصدر: Mucosal immunology [Mucosal Immunol] 2023 Oct; Vol. 16 (5), pp. 578-592. Date of Electronic Publication: 2023 Jun 10.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 101299742 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1935-3456 (Electronic) Linking ISSN: 19330219 NLM ISO Abbreviation: Mucosal Immunol Subsets: MEDLINE
أسماء مطبوعة: Publication: 2023- : [New York, NY] : Elsevier
Original Publication: New York, NY : Nature Pub. Group, c2008-
مواضيع طبية MeSH: Respiratory Syncytial Virus Infections* , Interferon Type I*/metabolism, Male ; Mice ; Female ; Humans ; Animals ; Chromatin Assembly and Disassembly ; Immunity, Innate ; Lung ; Chromatin/genetics ; Chromatin/metabolism
مستخلص: This study investigates sex-associated systemic innate immune differences by examining bone marrow-derived dendritic cells (BMDCs). BMDC grown from 7-day-old mice show enhanced type-I interferon (IFN) signaling in female compared to male BMDC. Upon respiratory syncytial virus (RSV) infection of 7-day-old mice, a significantly altered phenotype of BMDC at 4 weeks post-infection is observed in a sex-dependent manner. The alterations include heightened Ifnb/ interleukin (Il12a) and enhanced IFNAR1+ expression in BMDC from early-life RSV-infected female mice that leads to increased IFN-γ production by T cells. Phenotypic differences were verified upon pulmonary sensitization whereby EL-RSV male-derived BMDC promoted enhanced T helper 2/17 responses and exacerbated disease upon RSV infection while EL-RSV/F BMDC sensitization was relatively protective. Assay for transposase-accessible chromatin using sequencing analysis (ATAC-seq) demonstrated that EL-RSV/F BMDC had enhanced chromatin accessibility near type-I immune genes with JUN, STAT1/2, and IRF1/8 transcription factors predicted to have binding sites in accessible regions. Importantly, ATAC-seq of human cord blood-derived monocytes displayed a similar sex-associated chromatin landscape with female-derived monocytes having more accessibility in type-I immune genes. These studies enhance our understanding of sex-associated differences in innate immunity by epigenetically controlled transcriptional programs amplified by early-life infection in females via type-I immunity.
(Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.)
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معلومات مُعتمدة: F32 HL158001 United States HL NHLBI NIH HHS; P01 AI089473 United States AI NIAID NIH HHS; R01 AI138348 United States AI NIAID NIH HHS; R35 HL150682 United States HL NHLBI NIH HHS
المشرفين على المادة: 0 (Interferon Type I)
0 (Chromatin)
تواريخ الأحداث: Date Created: 20230611 Date Completed: 20231117 Latest Revision: 20240129
رمز التحديث: 20240130
مُعرف محوري في PubMed: PMC10646734
DOI: 10.1016/j.mucimm.2023.06.002
PMID: 37302711
قاعدة البيانات: MEDLINE
الوصف
تدمد:1935-3456
DOI:10.1016/j.mucimm.2023.06.002