دورية أكاديمية
High survival rate after the combination of intrameniscal and intraarticular infiltrations of platelet-rich plasma as conservative treatment for meniscal lesions.
| العنوان: | High survival rate after the combination of intrameniscal and intraarticular infiltrations of platelet-rich plasma as conservative treatment for meniscal lesions. |
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| المؤلفون: | Sánchez M; Arthroscopic Surgery Unit, Hospital Vithas Vitoria, Vitoria-Gasteiz, Spain.; Advanced Biological Therapy Unit, Hospital Vithas Vitoria, C/Beato Tomás de Zumárraga 10, 01008, Vitoria-Gasteiz, Spain., Jorquera C; Advanced Biological Therapy Unit, Hospital Vithas Vitoria, C/Beato Tomás de Zumárraga 10, 01008, Vitoria-Gasteiz, Spain., Bilbao AM; Arthroscopic Surgery Unit, Hospital Vithas Vitoria, Vitoria-Gasteiz, Spain., García S; Advanced Biological Therapy Unit, Hospital Vithas Vitoria, C/Beato Tomás de Zumárraga 10, 01008, Vitoria-Gasteiz, Spain., Beitia M; Advanced Biological Therapy Unit, Hospital Vithas Vitoria, C/Beato Tomás de Zumárraga 10, 01008, Vitoria-Gasteiz, Spain., Espregueira-Mendes J; Clínica Espregueira-FIFA Medical Centre of Excellence, Porto, Portugal.; Dom Henrique Research Centre, Porto, Portugal.; School of Medicine, University of Minho, Braga, Portugal.; ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Portugal.; 3B's Research Group-Biomaterials, Biodegradables and Biomimetics, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, University of Minho, Barco, Guimarães, Portugal., González S; Arthroscopic Surgery Unit, Hospital Vithas Vitoria, Vitoria-Gasteiz, Spain., Oraa J; Arthroscopic Surgery Unit, Hospital Vithas Vitoria, Vitoria-Gasteiz, Spain., Guadilla J; Arthroscopic Surgery Unit, Hospital Vithas Vitoria, Vitoria-Gasteiz, Spain., Delgado D; Advanced Biological Therapy Unit, Hospital Vithas Vitoria, C/Beato Tomás de Zumárraga 10, 01008, Vitoria-Gasteiz, Spain. diego.delgado@ucatrauma.com. |
| المصدر: | Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA [Knee Surg Sports Traumatol Arthrosc] 2023 Oct; Vol. 31 (10), pp. 4246-4256. Date of Electronic Publication: 2023 Jun 12. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley Country of Publication: Germany NLM ID: 9314730 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1433-7347 (Electronic) Linking ISSN: 09422056 NLM ISO Abbreviation: Knee Surg Sports Traumatol Arthrosc Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2024- : [Hoboken] : Wiley Original Publication: [Heidelberg, Germany] : Springer International, c1993- |
| مواضيع طبية MeSH: | Osteoarthritis* , Platelet-Rich Plasma* , Cartilage Diseases* , Osteoarthritis, Knee*/pathology, Humans ; Survival Rate ; Treatment Outcome ; Conservative Treatment ; Injections, Intra-Articular |
| مستخلص: | Purpose: To evaluate the efficacy of applying a combination of intrameniscal and intraarticular infiltrations of Platelet-Rich Plasma (PRP) in patients with meniscal tears, analyzing its failure rate and clinical evolution, as well as factors that may influence the positive response to this treatment. Methods: Three hundred and ninety-two cases out of 696 met the inclusion criteria and were included in this work. Survival and patient-reported outcome measure (PROM) were collected and analyzed. Survival rate was defined as the percentage of patients who did not undergo meniscus surgery during their follow-up time. Patients were asked to complete the Knee injury and Osteoarthritis Outcome Score (KOOS) at baseline, 6 months and 18 months. Other patient- and pathology-related variables were collected. Blood and PRP samples were randomly tested as a quality control measure. Survival and comparative statistical tests, and multivariate regression were performed for the analysis of the variables. Results: The PRP applied had a platelet concentration factor of 1.9X in respect to blood levels, with no leukocytes or erythrocytes. Thirty-eight patients required surgical intervention after treatment reaching a survival rate of 90.3% with an estimated mean survival time of 54.4 months. The type of injury (P = 0.002) and the presence of chondropathy were risk factors for surgical intervention after PRP treatment (P = 0.043). All KOOS scores showed a significant statistical increase from baseline to 6 months (N = 93) and 18 months (N = 66) (P < 0.0001). The number of cases with minimal clinically important improvement (MCII) at 6 months and 18 months post-treatment was 65 (69.9%) and 43 (65.2%), respectively. Conclusion: The combination of intrameniscal and intraarticular PRP infiltrations is a valid conservative treatment for meniscal injuries avoiding the need for surgical intervention. Its efficacy is higher in horizontal tears and decreases when joint degeneration is present. Level of Evidence: Level IV. (© 2023. The Author(s) under exclusive licence to European Society of Sports Traumatology, Knee Surgery, Arthroscopy (ESSKA).) |
| References: | Adams BG, Houston MN, Cameron KL (2021) The epidemiology of meniscus injury. Sports Med Arthrosc Rev 29(3):e24–e33. (PMID: 10.1097/JSA.000000000000032934398119) Alerskans S, Kostogiannis I, Neuman P (2022) Patient’s subjective knee function 3–5 years following partial meniscectomy or meniscus repair compared to a normal population: a retrospective cohort study. BMJ Open Sport Exerc Med 8(3):e001278. (PMID: 10.1136/bmjsem-2021-001278361111299438024) Alessio-Mazzola M, Felli L, Trentini R, Formica M, Capello AG, Lovisolo S, Maffulli N (2022) Efficacy of autologous platelet-rich plasma injections for grade 3 symptomatic degenerative meniscal lesions: a 1-year follow-up prospective study. Sports Health 14(2):227–236. (PMID: 10.1177/1941738121101107433896253) Beaufils P, Becker R, Kopf S, Englund M, Verdonk R, Ollivier M, Seil R (2017) Surgical Management of degenerative meniscus lesions: the 2016 ESSKA meniscus consensus. Joints 5(2):59–69. (PMID: 10.1055/s-0037-1603813291146335672871) Bedrin MD, Kartalias K, Yow BG, Dickens JF (2021) Degenerative joint disease after meniscectomy. Sports Med Arthrosc Rev 29(3):e44–e50. (PMID: 10.1097/JSA.000000000000030134398123) Betancourt JP, Murrell WD (2016) Leukocyte-poor platelet-rich plasma to treat degenerative meniscal tear: a case report. J Clin Orthop Trauma 7(Suppl 1):106–109. (PMID: 10.1016/j.jcot.2016.05.002280180865167441) Blough CL, Bobba CM, DiBartola AC, Everhart JS, Magnussen RA, Kaeding C, Flanigan DC (2021) Biologic augmentation during meniscal repair. J Knee Surg. https://doi.org/10.1055/s-0041-1739198. (PMID: 10.1055/s-0041-173919834781393) DePhillipo NN, LaPrade RF, Zaffagnini S, Mouton C, Seil R, Beaufils P (2021) The future of meniscus science: international expert consensus. J Exp Orthop 8(1):24. (PMID: 10.1186/s40634-021-00345-y337918908012449) Fernández-Matías R, García-Pérez F, Gavín-González C, Martínez-Martín J, Valencia-García H, Flórez-García MT (2023) Effectiveness of exercise versus arthroscopic partial meniscectomy plus exercise in the management of degenerative meniscal tears at 5-year follow-up: a systematic review and meta-analysis. Arch Orthop Trauma Surg 143(5):2609–2620. (PMID: 10.1007/s00402-022-04579-y35996030) Green JS, Seddio AE, Roybal D, Moran J, Katz LD, Medvecky MJ (2022) Spontaneous healing of a posteriorly displaced lateral meniscus bucket-handle tear in a multiligament knee injury: a case report. JBJS Case Connect. https://doi.org/10.2106/JBJS.CC.22.00503. (PMID: 10.2106/JBJS.CC.22.0050336821095) Guenoun D, Magalon J, de Torquemada I, Vandeville C, Sabatier F, Champsaur P, Jacquet C, Ollivier M (2020) Treatment of degenerative meniscal tear with intrameniscal injection of platelets rich plasma. Diagn Interv Imaging 101(3):169–176. (PMID: 10.1016/j.diii.2019.10.00331727602) Hagmeijer MH, Korpershoek JV, Crispim JF, Chen L-T, Jonkheijm P, Krych AJ, Saris DBF, Vonk LA (2021) The regenerative effect of different growth factors and platelet lysate on meniscus cells and mesenchymal stromal cells and proof of concept with a functionalized meniscus implant. J Tissue Eng Regen Med 15(7):648–659. (PMID: 10.1002/term.3218339824428362003) Kaminski R, Maksymowicz-Wleklik M, Kulinski K, Kozar-Kaminska K, Dabrowska-Thing A, Pomianowski S (2019) Short-term outcomes of percutaneous trephination with a platelet rich plasma intrameniscal injection for the repair of degenerative meniscal lesions. A prospective, randomized, double-blind, parallel-group, placebo-controlled study. Int J Mol Sci 20(4):E856. https://doi.org/10.3390/ijms20040856. (PMID: 10.3390/ijms20040856) Keller RE, O’Donnell EA, Medina GIS, Linderman SE, Cheng TTW, Sabbag OD, Oh LS (2022) Biological augmentation of meniscal repair: a systematic review. Knee Surg Sports Traumatol Arthrosc 30(6):1915–1926. (PMID: 10.1007/s00167-021-06849-535258647) Kon E, Di Matteo B, Delgado D, Cole BJ, Dorotei A, Dragoo JL, Filardo G, Fortier LA, Giuffrida A, Jo CH, Magalon J, Malanga GA, Mishra A, Nakamura N, Rodeo SA, Sampson S, Sánchez M (2020) Platelet-rich plasma for the treatment of knee osteoarthritis: an expert opinion and proposal for a novel classification and coding system. Expert Opin Biol Ther. https://doi.org/10.1080/14712598.2020.1798925. (PMID: 10.1080/14712598.2020.179892533138645) Lucas G, Accadbled F, Violas P, Sales de Gauzy J, Knörr J (2015) Isolated meniscal injuries in paediatric patients: outcomes after arthroscopic repair. Orthop Traumatol Surg Res 101(2):173–177. (PMID: 10.1016/j.otsr.2014.12.00625676892) Luvsannyam E, Jain MS, Leitao AR, Maikawa N, Leitao AE (2022) Meniscus tear: pathology, incidence, and management. Cureus 14(5):e25121. https://doi.org/10.7759/cureus.25121. (PMID: 10.7759/cureus.25121357334849205760) Maheshwer B, Wong SE, Polce EM, Paul K, Forsythe B, Bush-Joseph C, Bach BR, Yanke AB, Cole BJ, Verma NN, Chahla J (2021) Establishing the minimal clinically important difference and patient-acceptable symptomatic state after arthroscopic meniscal repair and associated variables for achievement. Arthroscopy 37(12):3479–3486. (PMID: 10.1016/j.arthro.2021.04.05833964390) Makris EA, Hadidi P, Athanasiou KA (2011) The knee meniscus: structure-function, pathophysiology, current repair techniques, and prospects for regeneration. Biomaterials 32(30):7411–7431. (PMID: 10.1016/j.biomaterials.2011.06.037217644383161498) McAllister DR, Motamedi AR (2001) Spontaneous healing of a bucket-handle lateral meniscal tear in an anterior cruciate ligament-deficient knee. A case report. Am J Sports Med 29(5):660–662. (PMID: 10.1177/0363546501029005220111573928) McDermott ID, Amis AA (2006) The consequences of meniscectomy. J Bone Joint Surg Br 88(12):1549–1556. (PMID: 10.1302/0301-620X.88B12.1814017159163) Migliorini F, Cuozzo F, Cipollaro L, Oliva F, Hildebrand F, Maffulli N (2022) Platelet-rich plasma (PRP) augmentation does not result in more favourable outcomes in arthroscopic meniscal repair: a meta-analysis. J Orthop Traumatol 23(1):8. (PMID: 10.1186/s10195-022-00630-1351297288821738) Mitev K, Longurov A (2019) Intra-articular platelet-rich plasma injections for treating knee pain associated with articular cartilage and degenerative meniscal lesions. Open Access Maced J Med Sci 7(15):2484–2487. (PMID: 10.3889/oamjms.2019.674316668526814463) Mordecai SC, Al-Hadithy N, Ware HE, Gupte CM (2014) Treatment of meniscal tears: an evidence based approach. World J Orthop 5(3):233–241. (PMID: 10.5312/wjo.v5.i3.233250358254095015) Nepple JJ, Dunn WR, Wright RW (2012) Meniscal repair outcomes at greater than five years: a systematic literature review and meta-analysis. J Bone Joint Surg Am 94(24):2222–2227. (PMID: 10.2106/JBJS.K.01584233186123528023) Neumann J, Kern K, Sun D, Foreman SC, Joseph GB, Gersing AS, Nevitt MC, McCulloch CE, Quitzke A, Link TM (2020) Cartilage degeneration post-meniscectomy performed for degenerative disease versus trauma: data from the osteoarthritis initiative. Skeletal Radiol 49(2):231–240. (PMID: 10.1007/s00256-019-03267-031289901) Nguyen JC, De Smet AA, Graf BK, Rosas HG (2014) MR imaging-based diagnosis and classification of meniscal tears. Radiographics 34(4):981–999. (PMID: 10.1148/rg.34412520225019436) Noorduyn JCA, van de Graaf VA, Willigenburg NW, Scholten-Peeters GGM, Kret EJ, van Dijk RA, Buchbinder R, Hawker GA, Coppieters MW, Poolman RW, ESCAPE Research Group (2022) Effect of physical therapy vs arthroscopic partial meniscectomy in people with degenerative meniscal tears: five-year follow-up of the ESCAPE randomized clinical trial. JAMA Netw Open 5(7):e2220394. (PMID: 10.1001/jamanetworkopen.2022.20394358023749270699) Ozeki N, Koga H, Sekiya I (2022) Degenerative meniscus in knee osteoarthritis: from pathology to treatment. Life (Basel) 12(4):603. https://doi.org/10.3390/life12040603. (PMID: 10.3390/life1204060335455094) Popescu MB, Carp M, Tevanov I, Nahoi CA, Stratila MA, Haram OM, Ulici A (2020) Isolated meniscus tears in adolescent patients treated with platelet-rich plasma intra-articular injections: 3-month clinical outcome. Biomed Res Int 2020:8282460. (PMID: 10.1155/2020/8282460325963817273443) Qi Y, Tang R, Shi Z, Feng G, Zhang W (2021) Wnt5a/Platelet-rich plasma synergistically inhibits IL-1β-induced inflammatory activity through NF-κB signaling pathway and prevents cartilage damage and promotes meniscus regeneration. J Tissue Eng Regen Med 15(7):612–624. (PMID: 10.1002/term.319833843153) Ronnblad E, Barenius B, Engstrom B, Eriksson K (2020) Predictive factors for failure of meniscal repair: a retrospective dual-center analysis of 918 consecutive cases. Orthop J Sports Med 8(3):2325967120905529. (PMID: 10.1177/2325967120905529322849367137129) Roos EM, Lohmander LS (2003) The knee injury and osteoarthritis outcome score (KOOS): from joint injury to osteoarthritis. Health Qual Life Outcomes 1:64. (PMID: 10.1186/1477-7525-1-6414613558280702) Sánchez M, Beitia M, Pompei O, Jorquera C, Sánchez P, Knörr J, Soldado F, López L, Oraa J, Bilbao AM, Fiz N, Guadilla J, Aizpurua B, Azofra J, Delgado D (2019) Isolation, activation, and mechanism of action of platelet-rich plasma and its applications for joint repair. Regen Med IntechOpen. https://doi.org/10.5772/intechopen.90543. (PMID: 10.5772/intechopen.90543) Sánchez M, Delgado D, Pompei O, Pérez JC, Sánchez P, Garate A, Bilbao AM, Fiz N, Padilla S (2019) Treating severe knee osteoarthritis with combination of intra-osseous and intra-articular infiltrations of platelet-rich plasma: an observational study. Cartilage 10(2):245–253. (PMID: 10.1177/194760351875646229448817) Sánchez M, Delgado D, Sánchez P, Fiz N, Azofra J, Orive G, Anitua E, Padilla S (2014) Platelet rich plasma and knee surgery. Biomed Res Int 2014:890630. (PMID: 10.1155/2014/890630253023104167644) Sánchez M, Jorquera C, de Dicastillo LL, Fiz N, Knörr J, Beitia M, Aizpurua B, Azofra J, Delgado D (2022) Real-world evidence to assess the effectiveness of platelet-rich plasma in the treatment of knee degenerative pathology: a prospective observational study. Ther Adv Musculoskelet Dis 14:1759720X221100304. (PMID: 10.1177/1759720X221100304357213219201351) Sihvonen R, Paavola M, Malmivaara A, Itälä A, Joukainen A, Kalske J, Nurmi H, Kumm J, Sillanpää N, Kiekara T, Turkiewicz A, Toivonen P, Englund M, Taimela S, Järvinen TLN, FIDELITY (Finnish Degenerative Meniscus Lesion Study) Investigators (2020) Arthroscopic partial meniscectomy for a degenerative meniscus tear: a 5 year follow-up of the placebo-surgery controlled FIDELITY (Finnish Degenerative Meniscus Lesion Study) trial. Br J Sports Med 54(22):1332–1339. (PMID: 10.1136/bjsports-2020-10281332855201) Urzen JM, Fullerton BD (2016) Nonsurgical resolution of a bucket handle meniscal tear: a case report. PM R 8(11):1115–1118. (PMID: 10.1016/j.pmrj.2016.05.01127283320) Wang Y, Yao C, Yang Z, Guo W (2020) Clinical efficacy of platelet-rich plasma as adjuvant therapy in patients undergoing arthroscopic repair of meniscal injury. J Int Med Res 48(9):300060520955059. (PMID: 10.1177/030006052095505932962482) Wesdorp MA, Eijgenraam SM, Meuffels DE, Bierma-Zeinstra SMA, Kleinrensink G-J, Bastiaansen-Jenniskens YM, Reijman M (2020) Traumatic meniscal tears are associated with meniscal degeneration. Am J Sports Med 48(10):2345–2352. (PMID: 10.1177/0363546520934766326630467401187) Wong C-C, Kuo T-F, Yang T-L, Tsuang Y-H, Lin M-F, Chang C-H, Lin Y-H, Chan WP (2017) Platelet-rich fibrin facilitates rabbit meniscal repair by promoting meniscocytes proliferation, migration, and extracellular matrix synthesis. Int J Mol Sci 18(8):E1722. (PMID: 10.3390/ijms18081722) Yang C-P, Hung K-T, Weng C-J, Chen AC-Y, Hsu K-Y, Chan Y-S (2021) Clinical outcomes of meniscus repair with or without multiple intra-articular injections of platelet rich plasma after surgery. J Clin Med 10(12):2546. https://doi.org/10.3390/jcm10122546. (PMID: 10.3390/jcm10122546342075548228048) Zaffagnini S, Poggi A, Reale D, Andriolo L, Flanigan DC, Filardo G (2021) Biologic augmentation reduces the failure rate of meniscal repair: a systematic review and meta-analysis. Orthop J Sports Med 9(2):2325967120981627. (PMID: 10.1177/2325967120981627337090047907660) |
| فهرسة مساهمة: | Keywords: Growth factors; Intraarticular; Intrameniscal; Meniscus; Platelet-rich plasma |
| تواريخ الأحداث: | Date Created: 20230611 Date Completed: 20230901 Latest Revision: 20231007 |
| رمز التحديث: | 20231007 |
| DOI: | 10.1007/s00167-023-07470-4 |
| PMID: | 37302993 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1433-7347 |
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| DOI: | 10.1007/s00167-023-07470-4 |