دورية أكاديمية
أعرض في EDS

Folic Acid-Functionalized Albumin/Graphene Oxide Nanocomposite to Simultaneously Deliver Curcumin and 5-Fluorouracil into Human Colorectal Cancer Cells: An In Vitro Study.

التفاصيل البيبلوغرافية
العنوان: Folic Acid-Functionalized Albumin/Graphene Oxide Nanocomposite to Simultaneously Deliver Curcumin and 5-Fluorouracil into Human Colorectal Cancer Cells: An In Vitro Study.
المؤلفون: Bardania H; Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran., Jafari F; Student Research Committee, Yasuj University of Medical Sciences, Yasuj, Iran., Baneshi M; Department of Chemistry, Cape Breton University, 1250 Grand Lake Road, Sydney, Nova Scotia, Canada B1P 6L2., Mahmoudi R; Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran., Ardakani MT; Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran., Safari F; Student Research Committee, Yasuj University of Medical Sciences, Yasuj, Iran., Barmak MJ; Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran.
المصدر: BioMed research international [Biomed Res Int] 2023 May 31; Vol. 2023, pp. 8334102. Date of Electronic Publication: 2023 May 31 (Print Publication: 2023).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Hindawi Pub. Co Country of Publication: United States NLM ID: 101600173 Publication Model: eCollection Cited Medium: Internet ISSN: 2314-6141 (Electronic) NLM ISO Abbreviation: Biomed Res Int Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York, NY : Hindawi Pub. Co.
مواضيع طبية MeSH: Graphite* , Curcumin*/pharmacology , Colonic Neoplasms*, Humans ; Fluorouracil/pharmacology ; Albumins ; Excipients ; Folic Acid
مستخلص: Background: Nowadays, due to various inherent properties, graphene-based nanoparticles are widely used in drug delivery research. On the other hand, folate receptors are highly expressed on the surface of human tumor cells. In this work, to enhance the 5-fluorouracil (5FU) and curcumin (Cur) effects on colon cancer, we constructed a folic acid- (FA-) modified codelivery carrier based on graphene nanoparticles (GO-Alb-Cur-FA-5FU).
Materials and Methods: The HUVEC and HT-29 were selected for evaluating the antitumor effect of the prepared nanocarriers. The structure of nanocarriers was characterized by FTIR spectroscopy, X-ray diffraction analysis, TEM microscopy, and a DLS analyzer. The efficiency of the prepared carrier was evaluated by fluorescence microscopy using Annexin V and the PI kit. The cytotoxicity of the carrier's component individually and the efficacy of the drug carrier GO-Alb-Cur-FA-5FU were assessed by MTT.
Results: The results of the pharmacological tests indicated that the new nanoparticles cause increased apparent toxicity in HT-29 cells. The apoptosis rate of the HT-29 and HUVEC cells treated with IC50 values of GO-Alb-Cur-FA-5FU for 48 h was higher than the cells treated with IC50 values of 5FU and Cur individually, which indicated the greater inhibitory efficacy of GO-Alb-Cur-FA-5FU than free drugs.
Conclusion: The designed GO-Alb-CUR-FA-5FU delivery system can be applied for targeting colon cancer cells and can be severe as a potential candidate for future drug development.
Competing Interests: The authors report no conflicts of interest in this work.
(Copyright © 2023 Hassan Bardania et al.)
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المشرفين على المادة: U3P01618RT (Fluorouracil)
0 (graphene oxide)
7782-42-5 (Graphite)
IT942ZTH98 (Curcumin)
0 (Albumins)
0 (Excipients)
935E97BOY8 (Folic Acid)
تواريخ الأحداث: Date Created: 20230612 Date Completed: 20230613 Latest Revision: 20230613
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10256446
DOI: 10.1155/2023/8334102
PMID: 37304465
قاعدة البيانات: MEDLINE
الوصف
تدمد:2314-6141
DOI:10.1155/2023/8334102