دورية أكاديمية
أعرض في EDS

The prognostic role of epidermal growth factor receptor mutation in completely resected ampullary adenocarcinoma.

التفاصيل البيبلوغرافية
العنوان: The prognostic role of epidermal growth factor receptor mutation in completely resected ampullary adenocarcinoma.
المؤلفون: Varol U; Medical Oncology Clinic, Izmir Democracy University Buca Seyfi Demirsoy Training and Research Hospital, Izmir, Turkey., Cakır E; Department of Pathology, Izmir Katip Celebi University, Ataturk Training and Research Hospital, Izmir, Turkey., Aktas S; Institute of Oncology, Dokuz Eylul University, Izmir, Turkey., Altun ZS; Institute of Oncology, Dokuz Eylul University, Izmir, Turkey., Dilek FH; Department of Pathology, Izmir Katip Celebi University, Ataturk Training and Research Hospital, Izmir, Turkey., Butun O; Department of Medical Oncology, Izmir Katip Celebi University, Ataturk Training and Research Hospital, Izmir, Turkey., Salman T; Department of Medical Oncology, Izmir Katip Celebi University, Ataturk Training and Research Hospital, Izmir, Turkey., Unlu AGD; Department of Pathology, Izmir Democracy University, Izmir, Turkey., Alacacioglu A; Department of Medical Oncology, Izmir Katip Celebi University, Ataturk Training and Research Hospital, Izmir, Turkey., Somali I; Institute of Oncology, Dokuz Eylul University, Izmir, Turkey.
المصدر: Polish journal of pathology : official journal of the Polish Society of Pathologists [Pol J Pathol] 2023; Vol. 74 (1), pp. 18-28.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Polish Society Of Pathologists Country of Publication: Poland NLM ID: 9437432 Publication Model: Print Cited Medium: Print ISSN: 1233-9687 (Print) Linking ISSN: 12339687 NLM ISO Abbreviation: Pol J Pathol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Kraków : Polish Society Of Pathologists, 1994-
مواضيع طبية MeSH: B7-H1 Antigen* , Adenocarcinoma*/genetics , Adenocarcinoma*/surgery, Humans ; Prognosis ; Programmed Cell Death 1 Receptor ; ErbB Receptors/genetics ; Pancreatic Neoplasms
مستخلص: The aim of this study is to make a differential diagnosis and prognosis of the ampullary adenocarcinoma subtypes. We also investigated the role of prognostic markers PD-1 and PD-L1, and epidermal growth factor receptor (EGFR). Local or locally advanced stage ampullary adenocarcinoma patients who had undergone pancreaticoduodenectomy at the time of diagnosis were included. MUC1, MUC2, MUC5AC, CDX2, CK7, CK20, PD-1, and PDL-1 were analysed immunohistochemically, and EGFR was analysed by real-time polymerase chain reaction. According to histopathological and immunohistochemical evaluation, we found 27 patients as pancreatobiliary type and 56 patients as intestinal type adenocarcinoma. The median survival of patients with intestinal and pancreatobiliary type adenocarcinoma was 23 months and 76 months ( p = 0.201), respectively. When the survival of PD1-positive ( n = 23) and PD-L1-positive ( n = 18) patients were compared with the patients with negative staining ( n = 60, n = 65), no significant difference was found. Epidermal growth factor receptor mutation was detected in a total of 6 patients, and 5 of these 6 mutations were shown in intestinal type tumours and one in a pancreatobiliary type tumour. A significant difference was determined in terms of overall survival for the patients with EGFR mutations compared to those without ( p = 0.008). In conclusion, we could reveal the prognostic significance of EGFR mutation, which is also a target molecule.
فهرسة مساهمة: Keywords: EGFR; intestinal; pancreatobiliary; prognosis.; ampullary cancer
المشرفين على المادة: 0 (B7-H1 Antigen)
0 (Programmed Cell Death 1 Receptor)
EC 2.7.10.1 (ErbB Receptors)
تواريخ الأحداث: Date Created: 20230612 Date Completed: 20230613 Latest Revision: 20231213
رمز التحديث: 20231215
DOI: 10.5114/pjp.2023.127044
PMID: 37306349
قاعدة البيانات: MEDLINE
الوصف
تدمد:1233-9687
DOI:10.5114/pjp.2023.127044