دورية أكاديمية
The Role of a Composite Fitness Score in the Association Between Low-Density Cholesterol and All-Cause Mortality in Older Adults: An Individual Patient Data Meta-Analysis.
| العنوان: | The Role of a Composite Fitness Score in the Association Between Low-Density Cholesterol and All-Cause Mortality in Older Adults: An Individual Patient Data Meta-Analysis. |
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| المؤلفون: | van der Ploeg MA; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands., Poortvliet RKE; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands., Bogaerts JMK; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands., van der Klei VMGTH; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands., Kerse N; School of Population Health, University of Auckland, Auckland, New Zealand., Rolleston A; The Centre for Health, Tauranga, New Zealand., Teh R; School of Population Health, University of Auckland, Auckland, New Zealand., Robinson L; Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK., Jagger C; Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK., Arai Y; Center for Supercentenarian Medical Research, Keio University School of Medicine, Tokyo, Japan., Shikimoto R; Center for Supercentenarian Medical Research, Keio University School of Medicine, Tokyo, Japan., Abe Y; Center for Supercentenarian Medical Research, Keio University School of Medicine, Tokyo, Japan., Blom JW; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands., Drewes YM; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands.; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands., Gussekloo J; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands.; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands. |
| المصدر: | The journals of gerontology. Series A, Biological sciences and medical sciences [J Gerontol A Biol Sci Med Sci] 2023 Aug 27; Vol. 78 (9), pp. 1708-1716. |
| نوع المنشور: | Meta-Analysis; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: published on behalf of the Gerontological Society of America by Oxford University Press Country of Publication: United States NLM ID: 9502837 Publication Model: Print Cited Medium: Internet ISSN: 1758-535X (Electronic) Linking ISSN: 10795006 NLM ISO Abbreviation: J Gerontol A Biol Sci Med Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Washington, DC : published on behalf of the Gerontological Society of America by Oxford University Press Original Publication: Washington, DC : Gerontological Society of America, c1995- |
| مواضيع طبية MeSH: | Cardiovascular Diseases*, Female ; Humans ; Aged ; Male ; Cholesterol, LDL ; Risk Factors |
| مستخلص: | Background: In the general population, an increase in low-density lipoprotein cholesterol (LDL-C) predicts higher cardiovascular disease risk, and lowering LDL-C can prevent cardiovascular disease and reduces mortality risk. Interestingly, in cohort studies that include very old populations, no or inverse associations between LDL-C and mortality have been observed. This study aims to investigate whether the association between LDL-C and mortality in the very old is modified by a composite fitness score. Methods: A 2-stage meta-analysis of individual participant data from the 5 observational cohort studies. The composite fitness score was operationalized by performance on a combination of 4 markers: functional ability, cognitive function, grip strength, and morbidity. We pooled hazard ratios (HR) from Cox proportional-hazards models for 5-year mortality risk for a 1 mmol/L increase in LDL-C. Models were stratified by high/low composite fitness score. Results: Composite fitness scores were calculated for 2 317 participants (median 85 years, 60% females participants), of which 994 (42.9%) had a high composite fitness score, and 694 (30.0%) had a low-composite fitness score. There was an inverse association between LDL-C and 5-year mortality risk (HR 0.87 [95% CI: 0.80-0.94]; p < .01), most pronounced in participants with a low-composite fitness score (HR 0.85 [95% CI: 0.75-0.96]; p = .01), compared to those with a high composite fitness score (HR = 0.98 [95% CI: 0.83-1.15]; p = .78), the test for subgroups differences was not significant. Conclusions: In this very old population, there was an inverse association between LDL-C and all-cause mortality, which was most pronounced in participants with a low-composite fitness scores. (© The Author(s) 2023. Published by Oxford University Press on behalf of The Gerontological Society of America.) |
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| معلومات مُعتمدة: | G0500997 United Kingdom MRC_ Medical Research Council; United Kingdom BB_ Biotechnology and Biological Sciences Research Council; United Kingdom BHF_ British Heart Foundation; United Kingdom DH_ Department of Health |
| فهرسة مساهمة: | Keywords: Activities of daily living; Cognition; Frailty; Grip strength; Oldest old |
| المشرفين على المادة: | 0 (Cholesterol, LDL) |
| تواريخ الأحداث: | Date Created: 20230614 Date Completed: 20230829 Latest Revision: 20240923 |
| رمز التحديث: | 20240923 |
| مُعرف محوري في PubMed: | PMC10460558 |
| DOI: | 10.1093/gerona/glad148 |
| PMID: | 37314150 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1758-535X |
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| DOI: | 10.1093/gerona/glad148 |