دورية أكاديمية
أعرض في EDS

Cardiac imaging and biomarkers for assessing myocardial fibrosis in children with hypertrophic cardiomyopathy.

التفاصيل البيبلوغرافية
العنوان: Cardiac imaging and biomarkers for assessing myocardial fibrosis in children with hypertrophic cardiomyopathy.
المؤلفون: Kirmani S; Department of Pediatrics, University of Wisconsin-Madison, Madison, WI., Woodard PK; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO., Shi L; New England Research Institute, Watertown, MA., Hamza TH; HealthCore, Watertown, MA., Canter CE; Department of Pediatrics, Washington University School of Medicine, St. Louis, MO., Colan SD; Department of Cardiology, Boston Children's Hospital, Boston, MA., Pahl E; Department of Pediatrics, Northwestern Feinberg School of Medicine, Chicago, IL., Towbin JA; Heart Institute, Le Bonheur Children's Hospital, Memphis, TN., Webber SA; Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN., Rossano JW; Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA., Everitt MD; Department of Pediatrics, Children's Hospital of Colorado, Aurora, CO., Molina KM; Department of Pediatrics, Primary Children's Hospital, Salt Lake City, UT., Kantor PF; Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, CA., Jefferies JL; Department of Medicine, University of Tennessee, Memphis, TN., Feingold B; Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA., Addonizio LJ; Department of Pediatrics, Columbia University Irving Medical Center, New York, NY., Ware SM; Department of Pediatrics and Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN., Chung WK; Department of Pediatrics, Columbia University Irving Medical Center, New York, NY., Ballweg JA; Department of Pediatrics, Helen DeVos Children's Hospital, Grand Rapids, MI., Lee TM; Department of Pediatrics, Columbia University Irving Medical Center, New York, NY., Bansal N; Department of Pediatrics, Children's Hospital at Montefiore, Bronx, NY., Razoky H; Department of Pediatrics, Children's Hospital of Michigan, Detroit, MI., Czachor J; Department of Pediatrics, Children's Hospital of Michigan, Detroit, MI., Lunze FI; Department of Cardiology, Boston Children's Hospital, Boston, MA; German Heart Center Berlin, Charité Medical School, Berlin, Germany., Marcus E; Department of Cardiology, Boston Children's Hospital, Boston, MA., Commean P; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO., Wilkinson JD; Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN., Lipshultz SE; Department of Pediatrics, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY. Electronic address: slipshul@buffalo.edu.
المصدر: American heart journal [Am Heart J] 2023 Oct; Vol. 264, pp. 153-162. Date of Electronic Publication: 2023 Jun 12.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Mosby Country of Publication: United States NLM ID: 0370465 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-6744 (Electronic) Linking ISSN: 00028703 NLM ISO Abbreviation: Am Heart J Subsets: MEDLINE
أسماء مطبوعة: Original Publication: St. Louis, MO : Mosby
مواضيع طبية MeSH: Contrast Media* , Cardiomyopathy, Hypertrophic*/diagnostic imaging, Adult ; Humans ; Child ; Infant ; Child, Preschool ; Adolescent ; Prospective Studies ; Gadolinium ; Fibrosis ; Biomarkers ; Magnetic Resonance Imaging, Cine ; Myocardium/pathology
مستخلص: Background: Myocardial fibrosis, as diagnosed on cardiac magnetic resonance imaging (cMRI) by late gadolinium enhancement (LGE), is associated with adverse outcomes in adults with hypertrophic cardiomyopathy (HCM), but its prevalence and magnitude in children with HCM have not been established. We investigated: (1) the prevalence and extent of myocardial fibrosis as detected by LGE cMRI; (2) the agreement between echocardiographic and cMRI measurements of cardiac structure; and (3) whether serum concentrations of N-terminal pro hormone B-type natriuretic peptide (NT-proBNP) and cardiac troponin-T are associated with cMRI measurements.
Methods: A cross-section of children with HCM from 9 tertiary-care pediatric heart centers in the U.S. and Canada were enrolled in this prospective NHLBI study of cardiac biomarkers in pediatric cardiomyopathy (ClinicalTrials.gov Identifier: NCT01873976). The median age of the 67 participants was 13.8 years (range 1-18 years). Core laboratories analyzed echocardiographic and cMRI measurements, and serum biomarker concentrations.
Results: In 52 children with non-obstructive HCM undergoing cMRI, overall low levels of myocardial fibrosis with LGE >2% of left ventricular (LV) mass were detected in 37 (71%) (median %LGE, 9.0%; IQR: 6.0%, 13.0%; range, 0% to 57%). Echocardiographic and cMRI measurements of LV dimensions, LV mass, and interventricular septal thickness showed good agreement using the Bland-Altman method. NT-proBNP concentrations were strongly and positively associated with LV mass and interventricular septal thickness (P < .001), but not LGE.
Conclusions: Low levels of myocardial fibrosis are common in pediatric patients with HCM seen at referral centers. Longitudinal studies of myocardial fibrosis and serum biomarkers are warranted to determine their predictive value for adverse outcomes in pediatric patients with HCM.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
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معلومات مُعتمدة: R01 HL137558 United States HL NHLBI NIH HHS; R01 HL139968 United States HL NHLBI NIH HHS; R01 CA211996 United States CA NCI NIH HHS; R01 HL111459 United States HL NHLBI NIH HHS; R01 HL109090 United States HL NHLBI NIH HHS; R01 HL053392 United States HL NHLBI NIH HHS
سلسلة جزيئية: ClinicalTrials.gov NCT01873976
المشرفين على المادة: 0 (Contrast Media)
AU0V1LM3JT (Gadolinium)
0 (Biomarkers)
تواريخ الأحداث: Date Created: 20230614 Date Completed: 20230918 Latest Revision: 20240410
رمز التحديث: 20240410
مُعرف محوري في PubMed: PMC11003360
DOI: 10.1016/j.ahj.2023.06.005
PMID: 37315879
قاعدة البيانات: MEDLINE
الوصف
تدمد:1097-6744
DOI:10.1016/j.ahj.2023.06.005