دورية أكاديمية
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Multitissue responses to exercise: a MoTrPAC feasibility study.

التفاصيل البيبلوغرافية
العنوان: Multitissue responses to exercise: a MoTrPAC feasibility study.
المؤلفون: Chambers TL; Human Performance Laboratory, Ball State University, Muncie, Indiana, United States., Stroh AM; Human Performance Laboratory, Ball State University, Muncie, Indiana, United States., Chavez C; Human Performance Laboratory, Ball State University, Muncie, Indiana, United States., Brandt AR; Human Performance Laboratory, Ball State University, Muncie, Indiana, United States., Claiborne A; Human Performance Laboratory, Ball State University, Muncie, Indiana, United States., Fountain WA; Human Performance Laboratory, Ball State University, Muncie, Indiana, United States., Gries KJ; Human Performance Laboratory, Ball State University, Muncie, Indiana, United States., Jones AM; Human Performance Laboratory, Ball State University, Muncie, Indiana, United States., Kuszmaul DJ; Human Performance Laboratory, Ball State University, Muncie, Indiana, United States., Lee GA; Human Performance Laboratory, Ball State University, Muncie, Indiana, United States., Lester BE; Human Performance Laboratory, Ball State University, Muncie, Indiana, United States., Lynch CE; Human Performance Laboratory, Ball State University, Muncie, Indiana, United States., Minchev K; Human Performance Laboratory, Ball State University, Muncie, Indiana, United States., Montenegro CF; Human Performance Laboratory, Ball State University, Muncie, Indiana, United States., Naruse M; Human Performance Laboratory, Ball State University, Muncie, Indiana, United States., Raue U; Human Performance Laboratory, Ball State University, Muncie, Indiana, United States., Trappe TA; Human Performance Laboratory, Ball State University, Muncie, Indiana, United States., Trappe S; Human Performance Laboratory, Ball State University, Muncie, Indiana, United States.
المصدر: Journal of applied physiology (Bethesda, Md. : 1985) [J Appl Physiol (1985)] 2023 Aug 01; Vol. 135 (2), pp. 302-315. Date of Electronic Publication: 2023 Jun 15.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Retracted Publication
اللغة: English
بيانات الدورية: Publisher: American Physiological Society Country of Publication: United States NLM ID: 8502536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1601 (Electronic) Linking ISSN: 01617567 NLM ISO Abbreviation: J Appl Physiol (1985) Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Bethesda, MD : American Physiological Society, c1985-
مواضيع طبية MeSH: Exercise*/physiology , Muscle, Skeletal*/physiology, Adult ; Humans ; Feasibility Studies ; Quadriceps Muscle/metabolism ; Energy Metabolism
مستخلص: We assessed the feasibility of the Molecular Transducers of Physical Activity Consortium (MoTrPAC) human adult clinical exercise protocols, while also documenting select cardiovascular, metabolic, and molecular responses to these protocols. After phenotyping and familiarization sessions, 20 subjects (25 ± 2 yr, 12 M, 8 W) completed an endurance exercise bout ( n = 8, 40 min cycling at 70% V̇o 2max ), a resistance exercise bout ( n = 6, ∼45 min, 3 sets of ∼10 repetition maximum, 8 exercises), or a resting control period ( n = 6, 40 min rest). Blood samples were taken before, during, and after (10 min, 2 h, and 3.5 h) exercise or rest for levels of catecholamines, cortisol, glucagon, insulin, glucose, free fatty acids, and lactate. Heart rate was recorded throughout exercise (or rest). Skeletal muscle (vastus lateralis) and adipose (periumbilical) biopsies were taken before and ∼4 h following exercise or rest for mRNA levels of genes related to energy metabolism, growth, angiogenesis, and circadian processes. Coordination of the timing of procedural components (e.g., local anesthetic delivery, biopsy incisions, tumescent delivery, intravenous line flushes, sample collection and processing, exercise transitions, and team dynamics) was reasonable to orchestrate while considering subject burden and scientific objectives. The cardiovascular and metabolic alterations reflected a dynamic and unique response to endurance and resistance exercise, whereas skeletal muscle was transcriptionally more responsive than adipose 4 h postexercise. In summary, the current report provides the first evidence of protocol execution and feasibility of key components of the MoTrPAC human adult clinical exercise protocols. Scientists should consider designing exercise studies in various populations to interface with the MoTrPAC protocols and DataHub. NEW & NOTEWORTHY This study highlights the feasibility of key aspects of the MoTrPAC adult human clinical protocols. This initial preview of what can be expected from acute exercise trial data from MoTrPAC provides an impetus for scientists to design exercise studies to interlace with the rich phenotypic and -omics data that will populate the MoTrPAC DataHub at the completion of the parent protocol.
التعليقات: Retraction in: J Appl Physiol (1985). 2023 Nov 1;135(5):1214. doi: 10.1152/japplphysiol.00210.2023_RET. (PMID: 37975719)
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معلومات مُعتمدة: U01 AR071133 United States AR NIAMS NIH HHS
فهرسة مساهمة: Keywords: MoTrPAC; adipose; gene expression; metabolism; skeletal muscle
سلسلة جزيئية: figshare 10.6084/m9.figshare.22806869
تواريخ الأحداث: Date Created: 20230615 Date Completed: 20230721 Latest Revision: 20240802
رمز التحديث: 20240802
مُعرف محوري في PubMed: PMC10393343
DOI: 10.1152/japplphysiol.00210.2023
PMID: 37318985
قاعدة البيانات: MEDLINE
الوصف
تدمد:1522-1601
DOI:10.1152/japplphysiol.00210.2023