دورية أكاديمية
Curcumin inhibits human cancer cell growth and migration through downregulation of SVCT2.
| العنوان: | Curcumin inhibits human cancer cell growth and migration through downregulation of SVCT2. |
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| المؤلفون: | Jang SY; Department of Applied Chemistry, Dongduk Women's University, Seoul, Korea.; Rappeler Company, Anyang, Gyeonggi-do, Korea., Kim J; Department of Applied Chemistry, Dongduk Women's University, Seoul, Korea., Hong E; Department of Applied Chemistry, Dongduk Women's University, Seoul, Korea., Lee K; Department of Applied Chemistry, Dongduk Women's University, Seoul, Korea., Na Y; Rappeler Company, Anyang, Gyeonggi-do, Korea., Yeom CH; Rappeler Company, Anyang, Gyeonggi-do, Korea., Park S; Department of Applied Chemistry, Dongduk Women's University, Seoul, Korea. |
| المصدر: | Cell biochemistry and function [Cell Biochem Funct] 2023 Aug; Vol. 41 (6), pp. 696-703. Date of Electronic Publication: 2023 Jun 15. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 8305874 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1099-0844 (Electronic) Linking ISSN: 02636484 NLM ISO Abbreviation: Cell Biochem Funct Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford, England : Wiley-Blackwell Original Publication: Guildford, Surrey : Butterworth Scientific Ltd., c1983- |
| مواضيع طبية MeSH: | Curcumin*/pharmacology , Neoplasms*/drug therapy , Sodium-Coupled Vitamin C Transporters*/drug effects, Humans ; Anti-Inflammatory Agents/pharmacology ; Antioxidants/pharmacology ; Down-Regulation ; Tumor Suppressor Protein p53 |
| مستخلص: | Curcumin is a natural polyphenol that is extracted from the rhizomes of the turmeric plant (Curcuma longa), a member of the ginger family. It has been used for centuries in traditional Indian and Chinese medicine for its medicinal properties, including anti-inflammatory, antioxidant and antitumor effects. SVCT2 (Solute Carrier Family 23 Member 2, also known as SLC23A2) is a protein that plays a role in the transport of Vitamin C (Ascorbic Acid) into cells. SVCT2 plays an important role in tumor progression and metastasis, however, the molecular mechanisms of curcumin on SVCT2 have not been studied to date. Curcumin treatment inhibited proliferation and migration of cancer cells in a dose dependent manner. We found that curcumin reduced the expression of SVCT2 in cancer cells with a wild type p53, but not in those with a mutant type of p53. SVCT2 downregulation also reduced the MMP2 activity. Taken together, our results indicate that curcumin inhibited human cancer cell growth and migration by regulating SVCT2 through a downregulating p53. These findings provide new insights into the molecular mechanisms of curcumin's anticancer effects and potential therapeutic strategies for the treatment of metastatic migration. (© 2023 John Wiley & Sons Ltd.) |
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| معلومات مُعتمدة: | NRF-2022R1A2C1004297 National Research Foundation of Korea(NRF) grant funded by the Korea government (MSIT) |
| فهرسة مساهمة: | Keywords: SVCT2; cell migration; cell proliferation; curcumin; p53 |
| المشرفين على المادة: | 0 (Anti-Inflammatory Agents) 0 (Antioxidants) IT942ZTH98 (Curcumin) 0 (Tumor Suppressor Protein p53) 0 (Sodium-Coupled Vitamin C Transporters) |
| تواريخ الأحداث: | Date Created: 20230616 Date Completed: 20231108 Latest Revision: 20231108 |
| رمز التحديث: | 20231109 |
| DOI: | 10.1002/cbf.3824 |
| PMID: | 37322603 |
| قاعدة البيانات: | MEDLINE |
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