دورية أكاديمية
Multi-site pre-therapeutic biopsies demonstrate genetic heterogeneity in patients with newly diagnosed diffuse large B-cell lymphoma.
| العنوان: | Multi-site pre-therapeutic biopsies demonstrate genetic heterogeneity in patients with newly diagnosed diffuse large B-cell lymphoma. |
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| المؤلفون: | Hersby DS; Department of Hematology, Rigshospitalet, Copenhagen, Denmark., Schejbel L; Department of Pathology, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark., Breinholt MF; Department of Pathology, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark., Høgdall E; Department of Pathology, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark., Nørgaard P; Department of Pathology, Hvidovre Hospitalet, Hvidovre, Denmark., Dencker D; Department of Radiology, Rigshospitalet, Copenhagen, Denmark., Nielsen TH; Department of Hematology, Rigshospitalet, Copenhagen, Denmark.; Danish Medicines Agency, Copenhagen, Denmark., Pedersen LM; Department of Hematology, Zealand Hospital, Roskilde, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Gang AO; Department of Hematology, Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. |
| المصدر: | Leukemia & lymphoma [Leuk Lymphoma] 2023 Sep; Vol. 64 (9), pp. 1527-1535. Date of Electronic Publication: 2023 Jun 16. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Country of Publication: United States NLM ID: 9007422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1029-2403 (Electronic) Linking ISSN: 10268022 NLM ISO Abbreviation: Leuk Lymphoma Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: [Philadelphia, PA] : Taylor & Francis Original Publication: Chur ; New York : London, UK : Harwood Academic Publishers ; Distributed by STBS, 1989- |
| مواضيع طبية MeSH: | Genetic Heterogeneity* , Lymphoma, Large B-Cell, Diffuse*/diagnosis , Lymphoma, Large B-Cell, Diffuse*/genetics , Lymphoma, Large B-Cell, Diffuse*/therapy, Humans ; Prospective Studies ; Mutation ; Biopsy |
| مستخلص: | Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease, both regarding clinical presentation, response to treatment and outcome. Recently, subclassification of DLBCL based on mutational profile has been suggested, and next generation sequencing (NGS) analysis may be relevant as part of the diagnostic workflow. This will, however, often be based on analysis of one tumor biopsy. Here, we present a prospective study where multi-site sampling was performed prior to treatment in patients with newly diagnosed DLBCL. Two spatially different biopsies from 16 patients were analyzed using NGS with an in-house 59-gene lymphoma panel. In 8/16 (50%) patients, mutational differences were found between the two biopsy sites, including differences in TP53 mutational status. Our data indicate that a biopsy from the extra-nodal site may represent the most advanced clone, and an extra-nodal biopsy should be preferred for analysis, if safely accessible. This will help ensure a standardized stratification and treatment decision. |
| فهرسة مساهمة: | Keywords: Genetic heterogeneity; TP53; diffuse large B-cell; extra-nodal; lymphoma |
| تواريخ الأحداث: | Date Created: 20230617 Date Completed: 20230831 Latest Revision: 20230928 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1080/10428194.2023.2220454 |
| PMID: | 37328933 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1029-2403 |
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| DOI: | 10.1080/10428194.2023.2220454 |