دورية أكاديمية
A comparison of cardiovascular and pulmonary morbidities and risk factors in breast cancer survivors compared to an age-matched female control group in the Lifelines prospective population cohort.
| العنوان: | A comparison of cardiovascular and pulmonary morbidities and risk factors in breast cancer survivors compared to an age-matched female control group in the Lifelines prospective population cohort. |
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| المؤلفون: | Spoor DS; Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., van den Bogaard VAB; Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Sijtsema NM; Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Van der Meer P; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., de Bock GH; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Langendijk JA; Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Maduro JH; Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Crijns APG; Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. Electronic address: a.p.g.crijns@umcg.nl. |
| المصدر: | Breast (Edinburgh, Scotland) [Breast] 2023 Aug; Vol. 70, pp. 49-55. Date of Electronic Publication: 2023 Jun 08. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9213011 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-3080 (Electronic) Linking ISSN: 09609776 NLM ISO Abbreviation: Breast Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2002- : Amsterdam : Elsevier Original Publication: Edinburgh ; New York : Churchill Livingstone, c1992- |
| مواضيع طبية MeSH: | Breast Neoplasms*/epidemiology , Breast Neoplasms*/therapy , Cancer Survivors*, Female ; Humans ; Control Groups ; Prospective Studies ; Risk Factors ; Survivors ; Morbidity |
| مستخلص: | Purpose: To provide more insight into late treatment-related toxicities among breast cancer (BC) survivors by comparing morbidities and risk factors between BC survivors and age-matched controls. Materials and Methods: All female participants diagnosed with BC before inclusion in Lifelines, a population-based cohort in the Netherlands, were selected and matched 1:4 to female controls without any oncological history on birth year. Baseline was defined as the age at BC diagnosis. Outcomes were obtained from questionnaires and functional analyses performed at entry to Lifelines (follow-up 1; FU1) and several years later (FU2). Cardiovascular and pulmonary events were defined as morbidities that were absent at baseline but present at FU1 or FU2. Results: The study consisted of 1,325 BC survivors and 5,300 controls. The median period from baseline (i.e., BC treatment) to FU1 and FU2 was 7 and 10 years, respectively. Among BC survivors more events of heart failure (OR: 1.72 [1.10-2.68]) and less events of hypertension (OR: 0.79 [0.66-0.94]) were observed. At FU2, more electrocardiographic abnormalities were found among BC survivors compared to controls (4.1% vs. 2.7%, respectively; p = 0.027) and Framingham scores for the 10-year risk of coronary heart disease were lower (difference: 0.37%; 95% CI [-0.70 to -0.03%]). At FU2, BC survivors had more frequently a forced vital capacity below the lower limit of normal than controls (5.4% vs. 2.9%, respectively; p = 0.040). Conclusion: BC survivors are at risk of late treatment-related toxicities despite a more favourable cardiovascular risk profile compared to age-matched female controls. Competing Interests: Declaration of competing interest The department of Radiation Oncology of the University Medical Center Groningen has research collaborations with IBA, Philips and Mirada as well as R&D collaboration agreements with RaySearch, Siemens, Elekta en Leonie. Moreover, author J.L. reports personal fees from IBA. (Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Age-matched control group; Late treatment-related toxicity; Modifiable risk factors; Survivorship |
| تواريخ الأحداث: | Date Created: 20230618 Date Completed: 20230717 Latest Revision: 20230718 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC10293765 |
| DOI: | 10.1016/j.breast.2023.06.002 |
| PMID: | 37331094 |
| قاعدة البيانات: | MEDLINE |
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