دورية أكاديمية
Detection of pneumococcus during hospitalization for SARS-CoV-2.
| العنوان: | Detection of pneumococcus during hospitalization for SARS-CoV-2. |
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| المؤلفون: | Stahlfeld A; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, LEPH823, 60 College St, New Haven, CT 06510, United States., Glick LR; Yale School of Medicine, 333 Cedar St, New Haven, CT 06511, United States., Ott IM; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, LEPH823, 60 College St, New Haven, CT 06510, United States., Craft SB; Yale School of Medicine, 333 Cedar St, New Haven, CT 06511, United States., Yolda-Carr D; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, LEPH823, 60 College St, New Haven, CT 06510, United States., Harden CA; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, LEPH823, 60 College St, New Haven, CT 06510, United States., Nakahata M; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, LEPH823, 60 College St, New Haven, CT 06510, United States., Farhadian SF; Yale School of Medicine, 333 Cedar St, New Haven, CT 06511, United States., Grant LR; Medical and Scientific Affairs, Pfizer Inc, 500 Arcola Rd, Collegeville, PA 19426, United States., Alexander-Parrish R; Medical and Scientific Affairs, Pfizer Inc, 500 Arcola Rd, Collegeville, PA 19426, United States., Arguedas A; Medical and Scientific Affairs, Pfizer Inc, 500 Arcola Rd, Collegeville, PA 19426, United States., Gessner BD; Medical and Scientific Affairs, Pfizer Inc, 500 Arcola Rd, Collegeville, PA 19426, United States., Weinberger DM; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, LEPH823, 60 College St, New Haven, CT 06510, United States., Wyllie AL; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, LEPH823, 60 College St, New Haven, CT 06510, United States. |
| المصدر: | FEMS microbes [FEMS Microbes] 2022 Oct 16; Vol. 3, pp. xtac026. Date of Electronic Publication: 2022 Oct 16 (Print Publication: 2022). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 9918227365806676 Publication Model: eCollection Cited Medium: Internet ISSN: 2633-6685 (Electronic) Linking ISSN: 26336685 NLM ISO Abbreviation: FEMS Microbes Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: [Oxford] : Oxford University Press, [2020]- |
| مستخلص: | Background: Infections with respiratory viruses [e.g. influenza and respiratory syncytial virus (RSV)] can increase the risk of severe pneumococcal infections. Likewise, pneumococcal coinfection is associated with poorer outcomes in viral respiratory infection. However, there are limited data describing the frequency of pneumococcus and SARS-CoV-2 coinfection and the role of coinfection in influencing COVID-19 severity. We, therefore, investigated the detection of pneumococcus in COVID-19 inpatients during the early pandemic period. Methods: The study included patients aged 18 years and older, admitted to the Yale-New Haven Hospital who were symptomatic for respiratory infection and tested positive for SARS-CoV-2 during March-August 2020. Patients were tested for pneumococcus through culture-enrichment of saliva followed by RT-qPCR (to identify carriage) and serotype-specific urine antigen detection (UAD) assays (to identify presumed lower respiratory tract pneumococcal disease). Results: Among 148 subjects, the median age was 65 years; 54.7% were male; 50.7% had an ICU stay; 64.9% received antibiotics; and 14.9% died while admitted. Pneumococcal carriage was detected in 3/96 (3.1%) individuals tested by saliva RT-qPCR. Additionally, pneumococcus was detected in 14/127 (11.0%) individuals tested by UAD, and more commonly in severe than moderate COVID-19 [OR: 2.20; 95% CI: (0.72, 7.48)]; however, the numbers were small with a high degree of uncertainty. None of the UAD-positive individuals died. Conclusions: Pneumococcal lower respiratory tract infection (LRTI), as detected by positive UAD, occurred in patients hospitalized with COVID-19. Moreover, pneumococcal LRTI was more common in those with more serious COVID-19 outcomes. Future studies should assess how pneumococcus and SARS-CoV-2 interact to influence COVID-19 severity in hospitalized patients. (© The Author(s) 2022. Published by Oxford University Press on behalf of FEMS.) |
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| فهرسة مساهمة: | Keywords: COVID-19; Streptococcus pneumoniae; saliva; urinary antigen detection |
| تواريخ الأحداث: | Date Created: 20230619 Latest Revision: 20231023 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC10117745 |
| DOI: | 10.1093/femsmc/xtac026 |
| PMID: | 37332510 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2633-6685 |
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| DOI: | 10.1093/femsmc/xtac026 |