دورية أكاديمية
The effect of glycine on oxidative stress, inflammation and renin-angiotensin system in kidneys and aorta of cyclosporine-administered rats.
| العنوان: | The effect of glycine on oxidative stress, inflammation and renin-angiotensin system in kidneys and aorta of cyclosporine-administered rats. |
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| المؤلفون: | Kalaycı R; Department of Laboratory Animals Science, Aziz Sancar Institude of Experimental Medicine, Istanbul University, Istanbul, Turkey., Bingül İ; Department of Medical Biochemistry, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey., Soluk-Tekkeşin M; Department of Pathology, Oncology Institute, Istanbul University, Istanbul, Turkey., Olgaç V; Department of Pathology, Oncology Institute, Istanbul University, Istanbul, Turkey., Bekpınar S; Department of Medical Biochemistry, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey., Uysal M; Retired Prof. Dr. Bakırkoy, Istanbul, Turkey. |
| المصدر: | Drug and chemical toxicology [Drug Chem Toxicol] 2024 Jul; Vol. 47 (4), pp. 473-482. Date of Electronic Publication: 2023 Jun 20. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Group Country of Publication: United States NLM ID: 7801723 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-6014 (Electronic) Linking ISSN: 01480545 NLM ISO Abbreviation: Drug Chem Toxicol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: [Philadelphia, PA] : Taylor & Francis Group Original Publication: New York, Dekker. |
| مواضيع طبية MeSH: | Oxidative Stress*/drug effects , Renin-Angiotensin System*/drug effects , Cyclosporine*/toxicity , Kidney*/drug effects , Kidney*/pathology , Kidney*/metabolism , NADPH Oxidase 4*/metabolism , Glycine*/pharmacology , Glycine*/analogs & derivatives , Glycine*/administration & dosage , Glycine*/toxicity , Rats, Wistar*, Animals ; Male ; Antioxidants/pharmacology ; Aorta/drug effects ; Aorta/metabolism ; Aorta/pathology ; Immunosuppressive Agents/toxicity ; Inflammation/chemically induced ; Inflammation/prevention & control ; Rats ; Angiotensin II ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/administration & dosage ; Receptor, Angiotensin, Type 1/metabolism ; Peptidyl-Dipeptidase A/metabolism |
| مستخلص: | Cyclosporine A (CsA) is an immunosuppressive drug, used in organ transplantations. Oxidative stress, inflammation and renin-angiotensin system (RAS) activation play an important role in CsA-toxicity. Glycine (Gly) has antioxidant and anti-inflammatory effects. In this study, Gly was investigated for its protective role against CsA-induced toxicity. CsA (20 mg/kg/day; subcutaneously) was administered to rats along with Gly injection (250 or 1000 mg/kg; intraperitoneally) for 21 days. Renal function markers [serum urea and creatinine and urinary protein and kidney injury molecule levels and creatinine clearance values] together with histopathological examinations were performed. Oxidative stress (reactive oxygen species, thiobarbutiric acid reactive substances, advanced oxidation products of protein, glutathione, ferric reducing anti-oxidant power and 4-hydroxynonenal levels), and inflammation (myeloperoxidase activity) were determined in kidney tissue. The RAS system [angiotensin II (Ang II) levels, and mRNA expressions of angiotensin converting enzyme (ACE), angiotensin II type-I receptor (AT1R)] and NADPH-oxidase 4 (NOX4) were measured in kidney and aorta. CsA caused significant disturbances in renal function markers, increases in oxidative stress and inflammation parameters and renal damage. Serum angiotensin II levels and mRNA expressions of ACE, AT1R and NOX4 elevated in the aorta and kidney of CsA-rats. Gly, especially its high-dose, alleviated renal function markers, oxidative stress, inflammation and renal damage in CsA-rats. Moreover, serum Ang II levels and mRNA expressions of ACE, AT1R and NOX4 decreased significantly in aorta and kidney in CsA-rats due to Gly treatment. Our results indicate that Gly may be useful for the prevention of CsA-induced renal and vascular toxicity. |
| فهرسة مساهمة: | Keywords: Glycine; cyclosporine; oxidative stress; rats; renal/vascular toxicity; renin-angiotensin system |
| المشرفين على المادة: | 83HN0GTJ6D (Cyclosporine) EC 1.6.3.- (NADPH Oxidase 4) TE7660XO1C (Glycine) EC 1.6.3.- (Nox4 protein, rat) 0 (Antioxidants) 0 (Immunosuppressive Agents) 11128-99-7 (Angiotensin II) 0 (Anti-Inflammatory Agents) 0 (Receptor, Angiotensin, Type 1) EC 3.4.15.1 (Peptidyl-Dipeptidase A) |
| تواريخ الأحداث: | Date Created: 20230620 Date Completed: 20240701 Latest Revision: 20240710 |
| رمز التحديث: | 20240711 |
| DOI: | 10.1080/01480545.2023.2219036 |
| PMID: | 37338155 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1525-6014 |
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| DOI: | 10.1080/01480545.2023.2219036 |