دورية أكاديمية
Neonatal pain score after use of paracetamol: Is there a relationship with serum trough concentration at steady state in preterm and term neonates?
| العنوان: | Neonatal pain score after use of paracetamol: Is there a relationship with serum trough concentration at steady state in preterm and term neonates? |
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| المؤلفون: | van den Berg RB, Laarman ARC, Bloem LT, Dijkstra JA, Veldkamp AI, Allegaert K, Swart EL, van Weissenbruch MM |
| المصدر: | International journal of clinical pharmacology and therapeutics [Int J Clin Pharmacol Ther] 2023 Aug; Vol. 61 (8), pp. 354-362. |
| نوع المنشور: | Observational Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Dustri-Verlag Dr. K. Feistle Country of Publication: Germany NLM ID: 9423309 Publication Model: Print Cited Medium: Print ISSN: 0946-1965 (Print) Linking ISSN: 09461965 NLM ISO Abbreviation: Int J Clin Pharmacol Ther Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Munchen : Dustri-Verlag Dr. K. Feistle Original Publication: München : Dustri-Verlag Dr. K. Feistle, c1994- |
| مواضيع طبية MeSH: | Acetaminophen* , Pain*/prevention & control, Infant, Newborn ; Humans ; Administration, Intravenous ; Retrospective Studies ; Anti-Bacterial Agents/therapeutic use |
| مستخلص: | Objective: An easy to establish and patient-friendly biomarker to guide dosing of paracetamol in neonates is currently not available. The aim of this study was to determine the potential association between the serum trough concentration and area under the curve (AUC) of paracetamol at steady state and differences in pain scores in preterm and term neonates. Materials and Methods: A retrospective observational study was performed, using an academic hospital database to identify neonates treated with intravenous or rectal paracetamol for at least 48 hours. At steady state, serum trough concentrations and the 24-hour AUC were determined. Pain was measured by COMFORTneo scores, before the 1 st and 6 th dose. Linear regression was performed to assess the association between serum trough concentration and 24-hour AUC and differences in pain scores. Subgroup analyses were performed for patients who received paracetamol due to a COMFORTneo score ≥ 14 (group 1) or who received prophylactic paracetamol because of upcoming surgery (group 2). Results: 21 neonates were included. The median (interquartile range (IQR)) serum trough concentration of paracetamol before the 6 th dose was 4.5 mg/L (2.7 - 8.5 mg/L). In subgroup 1, the median (IQR) COMFORTneo scores before the 1 st and 6 th dose were 17 (16.5 - 20) and 12 (11 - 16.5), respectively. In subgroup 2, the median (IQR) scores were 9 (8 - 10) and 11 (9 - 12), respectively. The serum trough concentration and 24-hour AUC were not associated with reduced pain scores (p = 0.12 and p = 0.67, respectively). Conclusion: No association was found between the serum trough concentration and 24-hour AUC of paracetamol at steady state and differences in pain scores in preterm and term neonates. Future research is needed to prospectively determine a patient-friendly biomarker to optimize the treatment with paracetamol. |
| المشرفين على المادة: | 362O9ITL9D (Acetaminophen) 0 (Anti-Bacterial Agents) |
| تواريخ الأحداث: | Date Created: 20230622 Date Completed: 20230726 Latest Revision: 20230726 |
| رمز التحديث: | 20230726 |
| DOI: | 10.5414/CP204431 |
| PMID: | 37347121 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0946-1965 |
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| DOI: | 10.5414/CP204431 |