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Neural activation of regions involved in food reward and cognitive control in young females with anorexia nervosa and atypical anorexia nervosa versus healthy controls.

التفاصيل البيبلوغرافية
العنوان: Neural activation of regions involved in food reward and cognitive control in young females with anorexia nervosa and atypical anorexia nervosa versus healthy controls.
المؤلفون: Eddy KT; Eating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston, MA, USA. keddy@mgh.harvard.edu.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA. keddy@mgh.harvard.edu., Plessow F; Neuroendocrine Unit, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Breithaupt L; Eating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston, MA, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA., Becker KR; Eating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston, MA, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA., Slattery M; Neuroendocrine Unit, Massachusetts General Hospital, Boston, MA, USA., Mancuso CJ; Neuroendocrine Unit, Massachusetts General Hospital, Boston, MA, USA., Izquierdo AM; Neuroendocrine Unit, Massachusetts General Hospital, Boston, MA, USA., Van De Water AL; Neuroendocrine Unit, Massachusetts General Hospital, Boston, MA, USA.; Division of Women's Health, Department of Medicine, and Department of Psychiatry, Brigham and Women's Hospital, Boston, MA, USA., Kahn DL; Neuroendocrine Unit, Massachusetts General Hospital, Boston, MA, USA., Dreier MJ; Eating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston, MA, USA., Ebrahimi S; Cambridge Eating Disorders Center, Cambridge, MA, USA., Deckersbach T; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; University of Applied Sciences, Diploma Hochschule, Bad Sooden-Allendorf, Germany., Thomas JJ; Eating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston, MA, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA., Holsen LM; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Division of Women's Health, Department of Medicine, and Department of Psychiatry, Brigham and Women's Hospital, Boston, MA, USA., Misra M; Neuroendocrine Unit, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Division of Pediatric Endocrinology, Mass General for Children, Boston, MA, USA., Lawson EA; Neuroendocrine Unit, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.
المصدر: Translational psychiatry [Transl Psychiatry] 2023 Jun 23; Vol. 13 (1), pp. 220. Date of Electronic Publication: 2023 Jun 23.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101562664 Publication Model: Electronic Cited Medium: Internet ISSN: 2158-3188 (Electronic) Linking ISSN: 21583188 NLM ISO Abbreviation: Transl Psychiatry Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York, NY : Nature Pub. Group
مواضيع طبية MeSH: Anorexia Nervosa*/diagnostic imaging, Adolescent ; Female ; Humans ; Magnetic Resonance Imaging/methods ; Food ; Cognition ; Reward
مستخلص: Anorexia nervosa (AN) and atypical AN (AtypAN) are complex neurobiological illnesses that typically onset in adolescence with an often treatment-refractory and chronic illness trajectory. Aberrant eating behaviors in this population have been linked to abnormalities in food reward and cognitive control, but prior studies have not examined respective contributions of clinical characteristics and metabolic state. Research is needed to identify specific disruptions and inform novel intervention targets to improve outcomes. Fifty-nine females with AN (n = 34) or AtypAN (n = 25), ages 10-22 years, all ≤90% expected body weight, and 34 age-matched healthy controls (HC) completed a well-established neuroimaging food cue paradigm fasting and after a standardized meal, and we used ANCOVA models to investigate main and interaction effects of Group and Appetitive State on blood oxygenation level-dependent (BOLD) activation for the contrast of exposure to high-calorie food images minus objects. We found main effects of Group with greater BOLD activation in the dorsal anterior cingulate cortex (dACC), dorsolateral prefrontal cortex (DLPFC), hippocampus, caudate, and putamen for AN/AtypAN versus HC groups, and in the three-group model including AN, AtypAN, and HC (sub-)groups, where differences were primarily driven by greater activation in the AtypAN subgroup versus HC group. We found a main effect of Appetitive State with increased premeal BOLD activation in the hypothalamus, amygdala, nucleus accumbens, and caudate for models that included AN/AtypAN and HC groups, and in BOLD activation in the nucleus accumbens for the model that included AN, AtypAN, and HC (sub-)groups. There were no interaction effects of Group with Appetitive State for any of the models. Our findings demonstrate robust feeding-state independent group effects reflecting greater neural activation of specific regions typically associated with reward and cognitive control processing across AN and AtypAN relative to healthy individuals in this food cue paradigm. Differential activation of specific brain regions in response to the passive viewing of high-calorie food images may underlie restrictive eating behavior in this clinical population.
(© 2023. The Author(s).)
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معلومات مُعتمدة: MH103402 U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH); MH112485 U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH); MH111127 U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH); MH108595 U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH); MH103402 U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH); MH103402, MH108595, MH120568 U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH); DK040561 U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases)
تواريخ الأحداث: Date Created: 20230623 Date Completed: 20230626 Latest Revision: 20231116
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC10290133
DOI: 10.1038/s41398-023-02494-3
PMID: 37353543
قاعدة البيانات: MEDLINE
الوصف
تدمد:2158-3188
DOI:10.1038/s41398-023-02494-3