دورية أكاديمية
Impact of the antidepressant Bupropion on the Dynamic Energy Budget of Daphnia magna.
| العنوان: | Impact of the antidepressant Bupropion on the Dynamic Energy Budget of Daphnia magna. |
|---|---|
| المؤلفون: | Chaabani S; Centre for Biodiversity Dynamics, Department of Biology, Norwegian University of Science and Technology (NTNU), 7491 Trondheim, Norway. Electronic address: safa.chaabani@ntnu.no., Einum S; Centre for Biodiversity Dynamics, Department of Biology, Norwegian University of Science and Technology (NTNU), 7491 Trondheim, Norway., Jaspers VLB; Department of Biology, Norwegian University of Science and Technology (NTNU), 7491 Trondheim, Norway., Asimakopoulos AG; Department of Chemistry, Norwegian University of Science and Technology (NTNU), 7491 Trondheim, Norway., Zhang J; Department of Chemistry, Norwegian University of Science and Technology (NTNU), 7491 Trondheim, Norway., Muller E; Department of Biology, Norwegian University of Science and Technology (NTNU), 7491 Trondheim, Norway; Marine Science Institute, University of California, Santa Barbara, CA 93116, USA; ibacon GmbH, Arheilger Weg 17, D-6430 Rossdorf, Germany. |
| المصدر: | The Science of the total environment [Sci Total Environ] 2023 Oct 15; Vol. 895, pp. 164984. Date of Electronic Publication: 2023 Jun 23. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0330500 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1026 (Electronic) Linking ISSN: 00489697 NLM ISO Abbreviation: Sci Total Environ Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam, Elsevier. |
| مواضيع طبية MeSH: | Bupropion*/toxicity , Water Pollutants, Chemical*/toxicity, Animals ; Daphnia ; Reproduction ; Aquatic Organisms ; Antidepressive Agents/toxicity |
| مستخلص: | Psychiatric drugs are considered among the emerging contaminants of concern in ecological risk assessment, due to their potential to disrupt homeostasis in aquatic organisms. Bupropion is an antidepressant that acts by selective reuptake inhibition of norepinephrine and dopamine. Little is known about this compound's effects on aquatic organisms, despite being detected in significant concentrations in both water and biota close to waste-water treatment plants and densely populated areas. Dynamic Energy Budget (DEB) models are flexible mechanistic tools that can be applied to understand toxic effects and extrapolate individual responses to higher biological levels and under untested environmental conditions. In this work, we used the stdDEB-TKTD (an application of the DEB theory to ecotoxicology) approach to investigate the possible physiological mode of action of Bupropion on the model organism Daphnia magna. Next, Dynamic Energy Budget Individual-Based Models (DEB-IBM) were used to extrapolate the results to the population level and to predict the combined effects of Bupropion exposure and food availability on the daphnids. Our results revealed an increasing negative effect of this antidepressant on the reproduction and survival of the animals with increasing concentration (0.004, 0.058, 0.58 and 58 μM). At the population level, we found that even the lowest used doses of Bupropion could reduce the population density and its reproductive output. The impacts are predicted to be stronger under limited food conditions. Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Sigurd Einum reports financial support was provided by Norwegian Research Council. Safa Chaabani reports a relationship with Norwegian University of Science and Technology that includes: employment. (Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Bupropion; DEB-IBM; Daphnia magna; Food availability; Population effects; stdDEB-TKTD |
| المشرفين على المادة: | 01ZG3TPX31 (Bupropion) 0 (Antidepressive Agents) 0 (Water Pollutants, Chemical) |
| تواريخ الأحداث: | Date Created: 20230625 Date Completed: 20230911 Latest Revision: 20230911 |
| رمز التحديث: | 20230911 |
| DOI: | 10.1016/j.scitotenv.2023.164984 |
| PMID: | 37356764 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-1026 |
|---|---|
| DOI: | 10.1016/j.scitotenv.2023.164984 |