دورية أكاديمية
أعرض في EDS

Respiratory mechanics and gas exchange in an ovine model of congenital heart disease with increased pulmonary blood flow and pressure.

التفاصيل البيبلوغرافية
العنوان: Respiratory mechanics and gas exchange in an ovine model of congenital heart disease with increased pulmonary blood flow and pressure.
المؤلفون: Soares JHN; Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, Davis, CA, United States., Raff GW; Department of Surgery, School of Medicine, University of California, Davis, Davis, CA, United States., Fineman JR; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, United States.; Department of Pediatrics, School of Medicine, University of California, San Francisco, San Francisco, CA, United States., Datar SA; Department of Pediatrics, School of Medicine, University of California, San Francisco, San Francisco, CA, United States.
المصدر: Frontiers in physiology [Front Physiol] 2023 Jun 09; Vol. 14, pp. 1188824. Date of Electronic Publication: 2023 Jun 09 (Print Publication: 2023).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101549006 Publication Model: eCollection Cited Medium: Print ISSN: 1664-042X (Print) Linking ISSN: 1664042X NLM ISO Abbreviation: Front Physiol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Lausanne : Frontiers Research Foundation
مستخلص: In a model of congenital heart disease (CHD), we evaluated if chronically increased pulmonary blood flow and pressure were associated with altered respiratory mechanics and gas exchange. Respiratory mechanics and gas exchange were evaluated in 6 shunt, 7 SHAM, and 7 control age-matched lambs. Lambs were anesthetized and mechanically ventilated for 15 min with tidal volume of 10 mL/kg, positive end-expiratory pressure of 5 cmH 2 O, and inspired oxygen fraction of 0.21. Respiratory system, lung and chest wall compliances (C rs , C L and C cw , respectively) and resistances (R rs , R L and R cw , respectively), and the profile of the elastic pressure-volume curve (%E 2 ) were evaluated. Arterial blood gases and volumetric capnography variables were collected. Comparisons between groups were performed by one-way ANOVA followed by Tukey-Kramer test for normally distributed data and with Kruskal-Wallis test followed by Steel-Dwass test for non-normally distributed data. Average C rs and C L in shunt lambs were 30% and 58% lower than in control, and 56% and 68% lower than in SHAM lambs, respectively. C cw was 52% and 47% higher and R cw was 53% and 40% lower in shunt lambs compared to controls and SHAMs, respectively. No difference in %E 2 was identified between groups. No difference in respiratory mechanics was observed between control and SHAM lambs. In shunt lambs, R cw , C rs and C L were decreased and C cw was increased when compared to control and SHAM lambs. Pulmonary gas exchange did not seem to be impaired in shunt lambs when compared to controls and SHAMs.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2023 Soares, Raff, Fineman and Datar.)
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معلومات مُعتمدة: R01 HL133034 United States HL NHLBI NIH HHS
فهرسة مساهمة: Keywords: congenital heart disease; gas exchange; left-to-right shunt; respiratory mechanics; surgical large animal model
تواريخ الأحداث: Date Created: 20230626 Latest Revision: 20231122
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC10288580
DOI: 10.3389/fphys.2023.1188824
PMID: 37362431
قاعدة البيانات: MEDLINE
الوصف
تدمد:1664-042X
DOI:10.3389/fphys.2023.1188824