دورية أكاديمية
Prevalence and Associated Factors of optrA -Positive- Enterococcus faecalis in Different Reservoirs around Farms in Vietnam.
| العنوان: | Prevalence and Associated Factors of optrA -Positive- Enterococcus faecalis in Different Reservoirs around Farms in Vietnam. |
|---|---|
| المؤلفون: | Ha HTA; Hanoi Medical University, Hanoi 100000, Vietnam.; Department of Microbiology, Vinh Medical University, Vinh 431000, Vietnam., Nguyen PTL; National Institute of Hygiene and Epidemiology, Hanoi 100000, Vietnam., Hung TTM; National Institute of Hygiene and Epidemiology, Hanoi 100000, Vietnam., Tuan LA; National Institute of Hygiene and Epidemiology, Hanoi 100000, Vietnam., Thuy BT; National Institute of Hygiene and Epidemiology, Hanoi 100000, Vietnam., Lien THM; National Institute of Hygiene and Epidemiology, Hanoi 100000, Vietnam., Thai PD; National Institute of Hygiene and Epidemiology, Hanoi 100000, Vietnam., Thanh NH; National Institute of Hygiene and Epidemiology, Hanoi 100000, Vietnam., Bich VTN; Oxford University Clinical Research Unit, Hanoi 100000, Vietnam., Anh TH; Hanoi Medical University, Hanoi 100000, Vietnam., Hanh NTH; National Institute of Hygiene and Epidemiology, Hanoi 100000, Vietnam., Minh NT; National Institute of Hygiene and Epidemiology, Hanoi 100000, Vietnam., Thanh DP; Oxford University Clinical Research Unit, Ho Chi Minh City 700000, Vietnam., Mai ST; Oxford University Clinical Research Unit, Ho Chi Minh City 700000, Vietnam., The HC; Oxford University Clinical Research Unit, Ho Chi Minh City 700000, Vietnam., Trung NV; Pasteur Institute in Ho Chi Minh City, Ho Chi Minh City 700000, Vietnam., Thu NH; PATH, Hanoi 100000, Vietnam., Duong TN; National Institute of Hygiene and Epidemiology, Hanoi 100000, Vietnam., Anh DD; National Institute of Hygiene and Epidemiology, Hanoi 100000, Vietnam., Ngoc PT; National Institute of Veterinary Research, Hanoi 100000, Vietnam., Bañuls AL; MIVEGEC (IRD-CNRS-Université de Montpellier), LMI DRISA, Centre IRD, 34394 Montpellier, France., Choisy M; Oxford University Clinical Research Unit, Ho Chi Minh City 700000, Vietnam.; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX1 4BH, UK., van Doorn HR; Oxford University Clinical Research Unit, Hanoi 100000, Vietnam.; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX1 4BH, UK., Suzuki M; National Institute of Infectious Diseases, Tokyo 162-0052, Japan., Hoang TH; Hanoi Medical University, Hanoi 100000, Vietnam.; National Institute of Hygiene and Epidemiology, Hanoi 100000, Vietnam. |
| المصدر: | Antibiotics (Basel, Switzerland) [Antibiotics (Basel)] 2023 May 24; Vol. 12 (6). Date of Electronic Publication: 2023 May 24. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101637404 Publication Model: Electronic Cited Medium: Print ISSN: 2079-6382 (Print) Linking ISSN: 20796382 NLM ISO Abbreviation: Antibiotics (Basel) Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI AG, 2012- |
| مستخلص: | Linezolid is an antibiotic of last resort for the treatment of infections caused by Gram-positive bacteria, including vancomycin-resistant enterococci. Enterococcus faecalis , a member of enterococci, is a significant pathogen in nosocomial infections. E. faecalis resistance to linezolid is frequently related to the presence of optrA, which is often co-carried with fex , phenicol exporter genes, and erm genes encoding macrolide resistance. Therefore, the common use of antibiotics in veterinary might promote the occurrence of optrA in livestock settings. This is a cross-sectional study aiming to investigate the prevalence of optrA positive E. faecalis (OPEfs) in 6 reservoirs in farms in Ha Nam province, Vietnam, and its associated factors and to explore genetic relationships of OPEfs isolates. Among 639 collected samples, the prevalence of OPEfs was highest in flies, 46.8% (51/109), followed by chickens 37.3% (72/193), dogs 33.3% (17/51), humans 18.7% (26/139), wastewater 16.4% (11/67) and pigs 11.3%, (14/80). The total feeding area and total livestock unit of the farm were associated with the presence of OPEfs in chickens, flies, and wastewater. Among 186 OPEfs strains, 86% were resistant to linezolid. The presence of optrA was also related to the resistant phenotype against linezolid and levofloxacin of E. faecalis isolates. Close genotypic relationships identified by Pulsed Field Gel Electrophoresis between OPEfs isolates recovered from flies and other reservoirs including chickens, pigs, dogs, and wastewater suggested the role of flies in the transmission of antibiotic-resistant pathogens. These results provided warnings of linezolid resistance although it is not used in livestock. |
| References: | Microb Genom. 2020 Jun;6(6):. (PMID: 32149599) Microorganisms. 2021 Apr 26;9(5):. (PMID: 33925822) Nat Microbiol. 2017 Feb 06;2:16260. (PMID: 28165472) Antimicrob Agents Chemother. 2020 May 21;64(6):. (PMID: 32253215) J Vet Med Sci. 2014 May;76(5):685-92. (PMID: 24476850) Environ Health Prev Med. 2015 Jul;20(4):243-52. (PMID: 25921603) Front Public Health. 2021 Feb 05;9:570650. (PMID: 33614576) Int J Food Microbiol. 2016 Nov 7;236:107-14. (PMID: 27467501) Travel Med Infect Dis. 2018 Mar - Apr;22:8-17. (PMID: 29482014) J Glob Antimicrob Resist. 2020 Sep;22:504-510. (PMID: 32439566) J Antimicrob Chemother. 2015 Aug;70(8):2182-90. (PMID: 25977397) FEMS Microbiol Lett. 2001 Jul 24;201(2):205-11. (PMID: 11470363) Ann Lab Med. 2020 Jul;40(4):321-325. (PMID: 32067432) Sci Total Environ. 2018 Aug 15;633:1345-1351. (PMID: 29758886) Expert Rev Anti Infect Ther. 2014 Oct;12(10):1221-36. (PMID: 25199988) Clin Microbiol Infect. 2012 Jul;18(7):619-25. (PMID: 22487203) FEMS Microbiol Lett. 2012 Jun;331(2):160-4. (PMID: 22486165) Proc Biol Sci. 2018 Apr 11;285(1876):. (PMID: 29643217) Vet Microbiol. 2017 Mar;201:252-256. (PMID: 28284617) Ann Intern Med. 2003 Jan 21;138(2):135-42. (PMID: 12529096) Antimicrob Resist Infect Control. 2017 Jul 17;6:75. (PMID: 28725421) Am J Trop Med Hyg. 2022 Jun 13;107(1):65-71. (PMID: 35895375) J Antimicrob Chemother. 2018 Dec 1;73(12):3254-3258. (PMID: 30272180) S Afr Med J. 2015 Apr 06;105(5):325. (PMID: 26242647) Prev Vet Med. 2021 Apr;189:105292. (PMID: 33621709) Virulence. 2012 Aug 15;3(5):421-33. (PMID: 23076243) Microb Ecol. 2014 Feb;67(2):380-91. (PMID: 24337146) Appl Environ Microbiol. 2006 Jun;72(6):4028-35. (PMID: 16751512) J Antimicrob Chemother. 2016 Jun;71(6):1466-73. (PMID: 26903276) Vet World. 2021 Dec;14(12):3216-3223. (PMID: 35153415) Infect Drug Resist. 2022 Jan 04;15:13-20. (PMID: 35018102) Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13339-44. (PMID: 18757750) Poult Sci. 2020 Nov;99(11):6055-6061. (PMID: 33142524) Emerg Infect Dis. 2012 Jul;18(7):1096-100. (PMID: 22709904) Clin Microbiol Infect. 2019 May;25(5):630.e1-630.e6. (PMID: 30076974) Trop Anim Health Prod. 2021 Jun 5;53(3):340. (PMID: 34089130) Antibiotics (Basel). 2022 May 03;11(5):. (PMID: 35625259) Microb Drug Resist. 2019 Jan/Feb;25(1):87-93. (PMID: 30153086) Plasmid. 2018 Sep;99:89-98. (PMID: 30253132) J Antimicrob Chemother. 2015 Jul;70(7):2144-52. (PMID: 25755000) Infect Drug Resist. 2018 Nov 20;11:2397-2409. (PMID: 30538507) Appl Environ Microbiol. 2015 Sep;81(18):6090-7. (PMID: 26150452) J Infect Public Health. 2017 Sep - Oct;10(5):617-623. (PMID: 28254461) Trop Med Infect Dis. 2019 May 31;4(2):. (PMID: 31159338) J Clin Microbiol. 1988 Nov;26(11):2465-6. (PMID: 3069867) Lancet Reg Health West Pac. 2023 Feb 02;32:100677. (PMID: 36798514) Microbiology (Reading). 2022 Feb;168(2):. (PMID: 35130141) J Clin Microbiol. 1995 Sep;33(9):2233-9. (PMID: 7494007) Microorganisms. 2020 Jul 30;8(8):. (PMID: 32751552) Sci Total Environ. 2023 Feb 1;858(Pt 1):159805. (PMID: 36461578) Antibiotics (Basel). 2021 Jun 30;10(7):. (PMID: 34209451) |
| معلومات مُعتمدة: | United Kingdom WT_ Wellcome Trust; 106680 United Kingdom WT_ Wellcome Trust |
| فهرسة مساهمة: | Keywords: E. faecalis; Vietnam; farms; flies; linezolid resistance; optrA livestock |
| تواريخ الأحداث: | Date Created: 20230628 Latest Revision: 20240705 |
| رمز التحديث: | 20240705 |
| مُعرف محوري في PubMed: | PMC10294904 |
| DOI: | 10.3390/antibiotics12060954 |
| PMID: | 37370273 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder كن أول من يترك تعليقا!