دورية أكاديمية
أعرض في EDS

Cardiac Cachexia in Left Ventricular Assist Device Recipients and the Implications of Weight Gain Early After Implantation.

التفاصيل البيبلوغرافية
العنوان: Cardiac Cachexia in Left Ventricular Assist Device Recipients and the Implications of Weight Gain Early After Implantation.
المؤلفون: Vest AR; CardioVascular Center Tufts Medical Center Boston MA USA., Price LL; Tufts Clinical and Translational Science Institute Tufts University Boston MA USA.; Institute of Clinical Research and Health Policy Studies Tufts Medical Center Boston MA USA., Chanda A; Department of Medicine University of Connecticut Hartford CT USA., Sweigart BA; Tufts Clinical and Translational Science Institute Tufts University Boston MA USA.; Institute of Clinical Research and Health Policy Studies Tufts Medical Center Boston MA USA., Chery J; CardioVascular Center Tufts Medical Center Boston MA USA., Lawrence M; CardioVascular Center Tufts Medical Center Boston MA USA., Parsly L; Frances Stern Nutrition Center Tufts Medical Center Boston MA USA., Gulati G; CardioVascular Center Tufts Medical Center Boston MA USA., Kiernan MS; CardioVascular Center Tufts Medical Center Boston MA USA., Upshaw JN; CardioVascular Center Tufts Medical Center Boston MA USA., Kawabori M; CardioVascular Center Tufts Medical Center Boston MA USA., Couper GS; CardioVascular Center Tufts Medical Center Boston MA USA., Saltzman E; Friedman School of Nutrition Science and Policy at Tufts University Boston MA USA.; USDA Jean Mayer Human Nutrition Research Center on Aging at Tufts University Boston MA USA.
المصدر: Journal of the American Heart Association [J Am Heart Assoc] 2023 Jul 04; Vol. 12 (13), pp. e029086. Date of Electronic Publication: 2023 Jun 29.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101580524 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2047-9980 (Electronic) Linking ISSN: 20479980 NLM ISO Abbreviation: J Am Heart Assoc Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Oxford : Wiley-Blackwell
مواضيع طبية MeSH: Heart-Assist Devices*/adverse effects , Heart Failure* , Malnutrition*, Humans ; Cachexia/etiology ; Registries ; Treatment Outcome ; Retrospective Studies
مستخلص: Background Severe cardiac cachexia or malnutrition are commonly considered relative contraindications to left ventricular assist device (LVAD) implantation, but post-LVAD prognosis for patients with cachexia is uncertain. Methods and Results Intermacs (Interagency Registry for Mechanically Assisted Circulatory Support) 2006 to 2017 was queried for the preimplantation variable cachexia/malnutrition. Cox proportional hazards modeling examined the relationship between cachexia and LVAD outcomes. Of 20 332 primary LVAD recipients with available data, 516 (2.54%) were reported to have baseline cachexia and had higher risk baseline characteristics. Cachexia was associated with higher mortality during LVAD support (unadjusted hazard ratio [HR], 1.36 [95% CI, 1.18-1.56]; P <0.0001), persisting after adjustment for baseline characteristics (adjusted HR, 1.23 [95% CI, 1.0-1.42]; P =0.005). Mean weight change at 12 months was +3.9±9.4 kg. Across the cohort, weight gain ≥5% during the first 3 months of LVAD support was associated with lower mortality (unadjusted HR, 0.90 [95% CI, 0.84-0.98]; P =0.012; adjusted HR, 0.89 [95% CI, 0.82-0.97]; P =0.006). Conclusions The proportion of LVAD recipients recognized to have cachexia preimplantation was low at 2.5%. Recognized cachexia was independently associated with higher mortality during LVAD support. Early weight gain ≥5% was independently associated with lower mortality during subsequent LVAD support.
References: Am J Cardiol. 2023 Jan 1;186:30-35. (PMID: 36343443)
Eur J Heart Fail. 2015 Apr;17(4):424-33. (PMID: 25704364)
Circ Heart Fail. 2022 May;15(5):e009012. (PMID: 35378982)
J Cachexia Sarcopenia Muscle. 2020 Oct;11(5):1242-1249. (PMID: 32767518)
J Card Fail. 2020 Feb;26(2):120-127. (PMID: 31704196)
J Card Fail. 2019 May;25(5):380-400. (PMID: 30877038)
Int Heart J. 2018 Jan 27;59(1):143-148. (PMID: 29332917)
JACC Heart Fail. 2018 Jun;6(6):476-486. (PMID: 29753673)
J Am Coll Cardiol. 2013 Feb 26;61(8):820-9. (PMID: 23333145)
Eur Heart J. 2013 Feb;34(7):512-9. (PMID: 23178647)
Am J Cardiol. 2013 Nov 1;112(9):1484-8. (PMID: 23891248)
J Heart Lung Transplant. 2020 Aug;39(8):774-781. (PMID: 32276809)
J Card Fail. 2019 Mar;25(3):188-194. (PMID: 30658084)
Am J Cardiol. 2013 Feb 15;111(4):574-81. (PMID: 23206923)
ESC Heart Fail. 2019 Jun;6(3):526-535. (PMID: 30929311)
Eur J Heart Fail. 2018 Nov;20(11):1580-1587. (PMID: 30160804)
J Heart Lung Transplant. 2013 Jan;32(1):31-5. (PMID: 23164534)
Am Heart J. 2008 May;155(5):883-9. (PMID: 18440336)
J Card Fail. 2023 Jan;29(1):116-118. (PMID: 36336141)
J Card Fail. 2020 Apr;26(4):287-297. (PMID: 31618696)
Circ Heart Fail. 2016 Sep;9(9):. (PMID: 27623768)
Nutr Clin Pract. 2014 Oct;29(5):686-91. (PMID: 24866345)
J Am Heart Assoc. 2018 Sep 4;7(17):e007251. (PMID: 30371170)
Endocrine. 2013 Jun;43(3):626-34. (PMID: 23179776)
Lancet. 1997 Apr 12;349(9058):1050-3. (PMID: 9107242)
Circ Heart Fail. 2017 Sep;10(9):. (PMID: 28912261)
J Heart Lung Transplant. 2018 Oct;37(10):1207-1217. (PMID: 30195832)
Cardiol Clin. 2022 May;40(2):199-207. (PMID: 35465894)
JACC Heart Fail. 2015 Jan;3(1):30-39. (PMID: 25447345)
JPEN J Parenter Enteral Nutr. 2012 May;36(3):275-83. (PMID: 22535923)
Palliat Med. 2022 Jul;36(7):1118-1128. (PMID: 35729767)
Circ Heart Fail. 2020 Jan;13(1):e006326. (PMID: 31959016)
ASAIO J. 2020 Apr;66(4):401-408. (PMID: 31192852)
فهرسة مساهمة: Keywords: cachexia; heart failure; malnutrition; mechanical circulatory support
تواريخ الأحداث: Date Created: 20230629 Date Completed: 20230706 Latest Revision: 20230721
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10356076
DOI: 10.1161/JAHA.122.029086
PMID: 37382139
قاعدة البيانات: MEDLINE
الوصف
تدمد:2047-9980
DOI:10.1161/JAHA.122.029086