دورية أكاديمية

Pathobiological analysis of african swine fever virus contact-exposed pigs and estimation of the basic reproduction number of the virus in Vietnam.

التفاصيل البيبلوغرافية
العنوان: Pathobiological analysis of african swine fever virus contact-exposed pigs and estimation of the basic reproduction number of the virus in Vietnam.
المؤلفون: Oh SI; Division of Animal Diseases & Health, Rural Development Administration, National Institute of Animal Science, Wanju, 55365, Republic of Korea.; Bio-Safety Research Institute and Laboratory of Veterinary Pathology, College of Veterinary Medicine, Jeonbuk National University, Iksan, 54596, Republic of Korea., Bui NA; Virology Department, National Institute of Veterinary Research, Hanoi, Vietnam., Bui VN; Virology Department, National Institute of Veterinary Research, Hanoi, Vietnam., Dao DT; Virology Department, National Institute of Veterinary Research, Hanoi, Vietnam., Cho A; Division of Animal Diseases & Health, Rural Development Administration, National Institute of Animal Science, Wanju, 55365, Republic of Korea., Lee HG; Division of Animal Diseases & Health, Rural Development Administration, National Institute of Animal Science, Wanju, 55365, Republic of Korea., Jung YH; Division of Animal Diseases & Health, Rural Development Administration, National Institute of Animal Science, Wanju, 55365, Republic of Korea., Do YJ; Division of Animal Diseases & Health, Rural Development Administration, National Institute of Animal Science, Wanju, 55365, Republic of Korea., Kim E; Division of Animal Diseases & Health, Rural Development Administration, National Institute of Animal Science, Wanju, 55365, Republic of Korea., Bok EY; Division of Animal Diseases & Health, Rural Development Administration, National Institute of Animal Science, Wanju, 55365, Republic of Korea., Hur TY; Division of Animal Diseases & Health, Rural Development Administration, National Institute of Animal Science, Wanju, 55365, Republic of Korea., Lee HS; International Livestock Research Institute, Hanoi, Vietnam. h.s.lee@cgiar.org.; College of Veterinary Medicine, Chungnam National University, Daejeon, 34134, Republic of Korea. h.s.lee@cgiar.org.
المصدر: Porcine health management [Porcine Health Manag] 2023 Jun 29; Vol. 9 (1), pp. 30. Date of Electronic Publication: 2023 Jun 29.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101684126 Publication Model: Electronic Cited Medium: Print ISSN: 2055-5660 (Print) Linking ISSN: 20555660 NLM ISO Abbreviation: Porcine Health Manag Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2015]-
مستخلص: Background: African swine fever (ASF), caused by African swine fever virus (ASFV), is a fatal disease affecting wild and domestic pigs. Since China reported the first ASF outbreak in August 2018, ASFV has swept over the neighbouring Asian countries. However, studies involving experimental pig-to-pig ASFV transmission in Vietnam are lacking. The main objective of this experimental study was to demonstrate the pathobiological characteristics of ASFV contact-exposed pigs and estimate their basic reproduction number (R 0 ) in Vietnam. Fifteen pigs were randomly divided into two groups: experimental (n = 10) and negative control (n = 5) groups. One pig in the experimental group was intramuscularly inoculated with ASFV strain from Vietnam in 2020 and housed with the uninoculated pigs during the study period (28 days).
Results: The inoculated pig died 6 days post-inoculation, and the final survival rate was 90.0%. We started observing viremia and excretion of ASFV 10 days post-exposure in contact-exposed pigs. Unlike the surviving and negative control pigs, all necropsied pigs showed severe congestive splenomegaly and moderate-to-severe haemorrhagic lesions in the lymph nodes. The surviving pig presented with mild haemorrhagic lesions in the spleen and kidneys. We used Susceptible-Infectious-Removed models for estimating R 0 . The R 0 values for exponential growth (EG) and maximum likelihood (ML) were calculated to be 2.916 and 4.015, respectively. In addition, the transmission rates (β) were estimated to be 0.729 (95% confidence interval [CI]: 0.379-1.765) for EG and 1.004 (95% CI: 0.283-2.450) for ML.
Conclusions: This study revealed pathobiological and epidemiological information in about pig-to-pig ASFV transmission. Our findings suggested that culling infected herds within a brief period of time may mitigate the spread of ASF outbreaks.
(© 2023. The Author(s).)
References: Transbound Emerg Dis. 2018 Dec;65(6):1482-1484. (PMID: 30102848)
Viruses. 2022 Nov 13;14(11):. (PMID: 36423121)
Viruses. 2021 Dec 20;13(12):. (PMID: 34960821)
Epidemiol Infect. 2016 Jan;144(1):25-34. (PMID: 25989921)
Porcine Health Manag. 2021 May 2;7(1):36. (PMID: 33934707)
Transbound Emerg Dis. 2019 May;66(3):1395-1398. (PMID: 30592384)
Transbound Emerg Dis. 2018 Oct;65(5):1318-1328. (PMID: 29679458)
Sci China Life Sci. 2021 May;64(5):752-765. (PMID: 33655434)
Vet Rec. 2016 Mar 12;178(11):262-7. (PMID: 26966305)
J Vet Med Sci. 2021 Oct 31;83(11):1653-1660. (PMID: 34526423)
Clin Infect Dis. 2011 Apr 1;52(7):911-6. (PMID: 21427399)
Proc Biol Sci. 2007 Feb 22;274(1609):599-604. (PMID: 17476782)
Emerg Infect Dis. 2019 Jan;25(1):1-4. (PMID: 30560777)
Transbound Emerg Dis. 2020 Mar 7;:. (PMID: 32145154)
Transbound Emerg Dis. 2022 Jul;69(4):e646-e658. (PMID: 34655504)
Transbound Emerg Dis. 2016 Oct;63(5):e436-40. (PMID: 25440300)
Vet Res. 2014 Sep 26;45:93. (PMID: 25256695)
Front Vet Sci. 2022 Sep 08;9:978398. (PMID: 36157181)
Front Vet Sci. 2022 Sep 06;9:957918. (PMID: 36118335)
Transbound Emerg Dis. 2021 May;68(3):1384-1391. (PMID: 32810366)
PLoS One. 2021 Mar 3;16(3):e0247770. (PMID: 33657173)
Vet Microbiol. 2013 Aug 30;165(3-4):296-304. (PMID: 23664069)
Antiviral Res. 2019 May;165:34-41. (PMID: 30836106)
Emerg Microbes Infect. 2019;8(1):438-447. (PMID: 30898043)
PLoS One. 2015 May 04;10(5):e0125842. (PMID: 25938429)
Parasit Vectors. 2010 Nov 30;3:115. (PMID: 21118485)
Vet Sci. 2022 Jun 14;9(6):. (PMID: 35737344)
Emerg Microbes Infect. 2020 Dec;9(1):628-630. (PMID: 32183615)
Virus Res. 2013 Apr;173(1):180-90. (PMID: 23313935)
Influenza Other Respir Viruses. 2009 Nov;3(6):267-76. (PMID: 19903209)
Virus Res. 2013 Apr;173(1):122-30. (PMID: 23137735)
Prev Vet Med. 2011 Dec 1;102(3):167-74. (PMID: 21840611)
Virus Res. 2020 Oct 2;287:198099. (PMID: 32755631)
Proc Biol Sci. 1999 May 22;266(1423):1085-90. (PMID: 10380685)
Animals (Basel). 2023 Feb 06;13(4):. (PMID: 36830359)
Transbound Emerg Dis. 2015 Dec;62(6):612-22. (PMID: 26432068)
Transbound Emerg Dis. 2015 Jun;62(3):272-9. (PMID: 23926953)
Transbound Emerg Dis. 2017 Dec;64(6):1858-1866. (PMID: 27667658)
Viruses. 2017 May 10;9(5):. (PMID: 28489063)
معلومات مُعتمدة: PJ01651701 Rural Development Administration; PJ01651701 Rural Development Administration; PJ01651701 Rural Development Administration; PJ01651701 Rural Development Administration; PJ01651701 Rural Development Administration; PJ01651701 Rural Development Administration; PJ01651701 Rural Development Administration; PJ01651701 Rural Development Administration; PJ01651701 Rural Development Administration
فهرسة مساهمة: Keywords: African swine fever; African swine fever virus; Basic reproduction number (R0); Pathobiology; Transmission rate (β); Vietnam
تواريخ الأحداث: Date Created: 20230629 Latest Revision: 20230724
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC10311738
DOI: 10.1186/s40813-023-00330-0
PMID: 37386526
قاعدة البيانات: MEDLINE
الوصف
تدمد:2055-5660
DOI:10.1186/s40813-023-00330-0