التفاصيل البيبلوغرافية
| العنوان: |
Exercise training induces thrombogenic benefits in recent but not late postmenopausal females. |
| المؤلفون: |
Nørregaard LB; Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark., Wickham KA; Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark.; Environmental Ergonomics Laboratory, Faculty of Applied Health Sciences, Brock University, St. Catharines, Ontario, Canada., Ehlers T; Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark., Rocha MP; Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark., Fischer M; Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark., Lundberg Slingsby MH; Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark., Cheung SS; Environmental Ergonomics Laboratory, Faculty of Applied Health Sciences, Brock University, St. Catharines, Ontario, Canada., Evans PA; Welsh Centre for Emergency Medicine Research, Morriston Hospital, Swansea Bay University Health Board, Swansea, United Kingdom.; Biomedical Sciences, Swansea University Medical School, Swansea, United Kingdom., Bangsbo J; Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark., Hellsten Y; Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark. |
| المصدر: |
American journal of physiology. Heart and circulatory physiology [Am J Physiol Heart Circ Physiol] 2023 Aug 01; Vol. 325 (2), pp. H346-H361. Date of Electronic Publication: 2023 Jun 30. |
| نوع المنشور: |
Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: |
English |
| بيانات الدورية: |
Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901228 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1539 (Electronic) Linking ISSN: 03636135 NLM ISO Abbreviation: Am J Physiol Heart Circ Physiol Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: Bethesda, Md. : American Physiological Society, |
| مواضيع طبية MeSH: |
Postmenopause* , Thrombosis*/prevention & control, Male ; Humans ; Female ; Infant ; Menopause ; Blood Platelets ; Exercise/physiology |
| مستخلص: |
Although regular physical activity is known to improve cardiovascular health in men, evidence for its beneficial effects in postmenopausal females is less convincing and it remains unclear whether initiation of exercise training soon after, rather than many years after menopause impacts the magnitude of training-induced adaptations. We evaluated exercise-induced changes in markers of thrombotic risk and conduit artery function in recent ≤5yr compared with late ≥10yr postmenopausal females. Fourteen recent ≤5yr and 13 late ≥10yr healthy postmenopausal females completed 8 wk of regular intensive exercise training, consisting of floorball and cycling. Markers of thrombotic risk and vascular health were assessed before and after the intervention, and data were analyzed using a linear mixed model. Exercise training reduced markers of thrombotic risk, including an 11% reduction ( P = 0.007) in agonist-induced platelet reactivity and a reduction ( P = 0.027) in incipient clot microstructure (∼40% reduction in clot mass) in the recent ≤5yr but not the late ≥10yr ( P = 0.380; P = 0.739, respectively) postmenopausal females. There was no change in conduit artery function, as measured by brachial (recent ≤5yr , P = 0.804; late ≥10yr , P = 0.311) and popliteal artery (recent ≤5yr , P = 0.130; late ≥10yr , P = 0.434) flow-mediated dilation. Only the late ≥10yr postmenopausal females exhibited an increase (by 9.6%, P = 0.022) in intracellular adhesion molecule-1 levels after training, which may have impacted the thrombogenic adaptation in this group. These findings suggest that 8 wk of high-intensity exercise training reduces thrombotic risk in recent ≤5yr , but not late ≥10yr postmenopausal females. Thus, regular physical activity initiated soon after, rather than many years after menopause and at a higher age, may be more efficient for reducing thrombogenic risk. NEW & NOTEWORTHY Eight weeks of high-intensity exercise training reduces platelet reactivity as well as blood clot density and strength in females ≤5 yr past menopause but not in females ≥10 yr past menopause. The divergent response in the late postmenopausal females may be explained by training-induced low-grade systemic inflammation. These findings suggest that regular physical activity initiated soon after menopause, compared with many years after menopause, may be more efficient for reducing the risk of blood clots. |
| فهرسة مساهمة: |
Keywords: exercise training; menopause; platelets; thrombosis; vascular function |
| سلسلة جزيئية: |
figshare 10.6084/m9.figshare.23600202 |
| تواريخ الأحداث: |
Date Created: 20230630 Date Completed: 20230724 Latest Revision: 20230803 |
| رمز التحديث: |
20240628 |
| DOI: |
10.1152/ajpheart.00054.2023 |
| PMID: |
37389949 |
| قاعدة البيانات: |
MEDLINE |
