دورية أكاديمية
Examining the Association Between a Modified Quan-Charlson Comorbidity Index and HIV Viral Suppression: A Cross-Sectional Analysis of DC Cohort Participants.
| العنوان: | Examining the Association Between a Modified Quan-Charlson Comorbidity Index and HIV Viral Suppression: A Cross-Sectional Analysis of DC Cohort Participants. |
|---|---|
| المؤلفون: | Ramirez HC; Department of Epidemiology, Milken Institute School of Public Health, George Washington University, Washington, District of Columbia, USA., Monroe AK; Department of Epidemiology, Milken Institute School of Public Health, George Washington University, Washington, District of Columbia, USA., Byrne M; Department of Epidemiology, Milken Institute School of Public Health, George Washington University, Washington, District of Columbia, USA., O'Connor LF; Department of Epidemiology, Milken Institute School of Public Health, George Washington University, Washington, District of Columbia, USA. |
| المصدر: | AIDS research and human retroviruses [AIDS Res Hum Retroviruses] 2023 Dec; Vol. 39 (12), pp. 662-670. Date of Electronic Publication: 2023 Jul 27. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: Mary Ann Liebert Country of Publication: United States NLM ID: 8709376 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1931-8405 (Electronic) Linking ISSN: 08892229 NLM ISO Abbreviation: AIDS Res Hum Retroviruses Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Larchmont, NY : Mary Ann Liebert Original Publication: [New York] : Mary Ann Liebert, [c1987- |
| مواضيع طبية MeSH: | HIV Infections*/drug therapy , HIV Infections*/epidemiology , Acquired Immunodeficiency Syndrome*/drug therapy, Humans ; Male ; Adolescent ; Adult ; Cross-Sectional Studies ; Anti-Retroviral Agents/therapeutic use ; Comorbidity ; Viral Load |
| مستخلص: | With the advancement of effective antiretroviral therapy, people with HIV live longer, and many are developing non-AIDS comorbidities. It is important to assess how comorbidities are associated with HIV-related health outcomes, such as viral suppression (VS). The aim of this study was to analyze the association between comorbidity burden, measured using a modified Quan-Charlson Comorbidity Index (QCCI), and VS (viral load result of <200 copies/mL). We hypothesized that an increase in QCCI score, indicating a higher risk for mortality, would correlate with lower likelihood of VS because of the burden of comorbidity treatment, possibly leading to worse antiretroviral adherence. Our analysis included participants from the DC Cohort Longitudinal HIV Study in Washington, DC. Eligible participants were aged ≥18 years and enrolled in the cohort as of January 1, 2018 ( n = 2,471). A modified QCCI score, which weighs selected comorbidities (not including HIV/AIDS) and predicts mortality, was calculated using International Classification of Disease-9/10 codes from electronic health records. Multivariable logistic regressions were used to characterize the association between QCCI composite scores and VS. Participants were predominantly virally suppressed (89.6%), male (73.9%), non-Hispanic Black (74.7%), and between 18 and 55 years (59.3%). The median QCCI score was 1 (range = 1-12, interquartile range = 0-2), demonstrating predominately low mortality risk. We did not establish a statistically significant association between QCCI score and VS (adjusted odds ratio = 1.06, 95% confidence interval 0.96-1.17). Our findings suggest that a higher QCCI score was not associated with lower VS in this population, which may be partly due to the high retention in care among cohort participants. |
| References: | AIDS. 2021 May 1;35(Suppl 1):S39-S51. (PMID: 33867488) Lancet HIV. 2017 Aug;4(8):e349-e356. (PMID: 28501495) PLoS One. 2018 Sep 21;13(9):e0203895. (PMID: 30240419) Am Health Drug Benefits. 2019 Jun-Jul;12(4):188-197. (PMID: 31428236) Am J Epidemiol. 2011 Mar 15;173(6):676-82. (PMID: 21330339) J Chronic Dis. 1987;40(5):373-83. (PMID: 3558716) Clin Infect Dis. 2011 Dec;53(11):1120-6. (PMID: 21998278) Med Care. 2005 Nov;43(11):1130-9. (PMID: 16224307) BMJ. 2009 Jan 26;338:a3172. (PMID: 19171560) Clin Infect Dis. 2018 Apr 3;66(8):1230-1238. (PMID: 29149237) Am J Med. 2005 Aug;118(8):890-8. (PMID: 16084183) Clin Infect Dis. 2007 Dec 15;45(12):1593-601. (PMID: 18190322) HIV Med. 2017 Nov;18(10):724-735. (PMID: 28503912) Clin Infect Dis. 2020 Oct 23;71(7):e151-e158. (PMID: 31701144) PLoS One. 2016 Aug 15;11(8):e0160460. (PMID: 27525413) J Acquir Immune Defic Syndr. 2017 Aug 15;75(5):548-553. (PMID: 28471841) PLoS One. 2019 May 9;14(5):e0215764. (PMID: 31071105) Health Aff (Millwood). 2019 Jul;38(7):1163-1172. (PMID: 31260344) AIDS Patient Care STDS. 2013 Jan;27(1):5-16. (PMID: 23305257) J Acquir Immune Defic Syndr. 2015 Apr 1;68(4):413-9. (PMID: 25559604) J Clin Epidemiol. 1992 Jun;45(6):613-9. (PMID: 1607900) J Assoc Nurses AIDS Care. 2011 Jan-Feb;22(1):17-25. (PMID: 20471864) J Acquir Immune Defic Syndr. 2011 Aug 1;57(4):334-9. (PMID: 21522017) Lancet HIV. 2019 Dec;6(12):e869-e877. (PMID: 31776099) J Am Med Inform Assoc. 2016 May;23(3):635-43. (PMID: 26721732) J Acquir Immune Defic Syndr. 2012 Jul 1;60 Suppl 1:S1-18. (PMID: 22688010) Med Care. 2015 Sep;53(9):e65-72. (PMID: 23703645) Am J Med. 1996 Dec;101(6):605-11. (PMID: 9003107) AIDS Behav. 2014 Mar;18(3):617-24. (PMID: 23695522) Med Care. 2009 May;47(5):560-7. (PMID: 19318998) J Acquir Immune Defic Syndr. 2015 May 1;69 Suppl 1:S1-7. (PMID: 25867773) Lancet HIV. 2015 Jul;2(7):e288-98. (PMID: 26423253) AIDS Care. 2016 Nov;28(11):1355-64. (PMID: 27297952) Clin Infect Dis. 2019 Feb 15;68(5):795-802. (PMID: 30169624) Am J Manag Care. 2019 Dec;25(12):580-586. (PMID: 31860226) J Med Virol. 2020 Dec;92(12):3254-3264. (PMID: 32314818) AIDS. 2019 Dec 1;33(15):2327-2335. (PMID: 31764098) J Clin Epidemiol. 1994 Nov;47(11):1245-51. (PMID: 7722560) JMIR Public Health Surveill. 2020 Apr 15;6(2):e16061. (PMID: 32293567) AIDS Res Hum Retroviruses. 2020 Jun;36(6):475-489. (PMID: 32027170) |
| معلومات مُعتمدة: | R24 AI152598 United States AI NIAID NIH HHS; UM1 AI069503 United States AI NIAID NIH HHS |
| فهرسة مساهمة: | Keywords: Quan-Charlson comorbidity index; comorbidity; human immunodeficiency virus; viral suppression |
| المشرفين على المادة: | 0 (Anti-Retroviral Agents) |
| تواريخ الأحداث: | Date Created: 20230701 Date Completed: 20231216 Latest Revision: 20240709 |
| رمز التحديث: | 20240710 |
| مُعرف محوري في PubMed: | PMC10712358 |
| DOI: | 10.1089/AID.2022.0186 |
| PMID: | 37392022 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1931-8405 |
|---|---|
| DOI: | 10.1089/AID.2022.0186 |