دورية أكاديمية
أعرض في EDS

Acacia nilotica stem bark extract ameliorates obesity, hyperlipidemia, and insulin resistance in a rat model of high fat diet-induced obesity.

التفاصيل البيبلوغرافية
العنوان: Acacia nilotica stem bark extract ameliorates obesity, hyperlipidemia, and insulin resistance in a rat model of high fat diet-induced obesity.
المؤلفون: Khalaf SS; Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo, Egypt., Shalaby OA; Department of Medicinal and Aromatic Plants, Desert Research Center, El-Matariya, 11753, Cairo, Egypt., Hassan AR; Department of Medicinal and Aromatic Plants, Desert Research Center, El-Matariya, 11753, Cairo, Egypt., El-Kherbetawy MK; Department of Pathology, Faculty of Medicine, Suez Canal University, Ismailia, 41522, Egypt., Mehanna ET; Department of Biochemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, 41522, Egypt.
المصدر: Journal of traditional and complementary medicine [J Tradit Complement Med] 2023 Mar 08; Vol. 13 (4), pp. 397-407. Date of Electronic Publication: 2023 Mar 08 (Print Publication: 2023).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier B.V. on behalf of the Center for Food and Biomolecules, National Taiwan University Country of Publication: Netherlands NLM ID: 101605474 Publication Model: eCollection Cited Medium: Print ISSN: 2225-4110 (Print) Linking ISSN: 22254110 NLM ISO Abbreviation: J Tradit Complement Med Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: Amsterdam : Elsevier B.V. on behalf of the Center for Food and Biomolecules, National Taiwan University
Original Publication: Philadelphia, PA : [Taipei] : Wolters Kluwer Health, Medknow ; Committee on Chinese Medicine and Pharmacy
مستخلص: Background and Aim: Acacia nilotica ( A. nilotica ) is an imperative plant with many medicinal uses. The current study aimed to investigate the protective effects of the stem bark of A. nilotica and its fractions in a high fat diet (HFD) rat model.
Experimental Procedure: Seventy-two male albino rats were randomly divided into 9 groups, 8 rats per each. Group 1 was the normal control and received standard balanced diet. All the remaining groups were fed HFD for 8 weeks to induce obesity. Group 2 served as the HFD control group, group 3 received orlistat (5 mg/kg/day), groups 4 and 5 received total extract of A. nilotica stem bark (250 and 500 mg/kg). Groups 6 and 7 received A. nilotica ethyl acetate fraction (250 and 500 mg/kg), while groups 8 and 9 received butanol fraction (250 and 500 mg/kg).
Results and Conclusion: Both doses of the ethyl acetate fraction of the stem bark of A. nilotica significantly decreased the body weight, blood glucose, lipid profile and improved insulin sensitivity. Levels of MDA, leptin and inflammatory cytokines were significantly decreased by the ethyl acetate fraction while adiponectin and HDL-C were significantly increased relative to the HFD control group. Both doses of the ethyl acetate fraction significantly abolished HDF induced oxidative stress and normalized the values of antioxidant enzymes. Furthermore, metabolic profiling of the ethyl acetate fraction was performed by UHPLC/Q-TOF-MS. In conclusion, the ethyl acetate fraction of A. nilotica stem bark possessed antioxidant, anti-inflammatory and insulin sensitizing properties in HFD rat model.
Competing Interests: The authors declare no conflicts of interest.
(© 2023 Center for Food and Biomolecules, National Taiwan University. Production and hosting by Elsevier Taiwan LLC.)
References: J Tradit Complement Med. 2018 Sep 29;9(3):221-226. (PMID: 31193933)
J Pharm Biomed Anal. 2011 Sep 10;56(2):228-39. (PMID: 21684707)
Pharmacol Res. 2005 Oct;52(4):313-20. (PMID: 15979893)
Food Chem. 2019 Jun 1;282:9-17. (PMID: 30711110)
Chromatographia. 2009 Jun;69(Suppl 2):167-173. (PMID: 19554204)
Sci Rep. 2022 Jun 7;12(1):9370. (PMID: 35672366)
Mol Cells. 2020 Aug 31;43(8):686-693. (PMID: 32624503)
Int J Biochem Cell Biol. 2016 Dec;81(Pt B):383-392. (PMID: 27592457)
Int J Biol Macromol. 2020 May 1;150:31-37. (PMID: 32035149)
Front Cell Dev Biol. 2019 Sep 10;7:185. (PMID: 31552248)
Metabolism. 2019 Mar;92:61-70. (PMID: 30586573)
J Pak Med Assoc. 2015 Dec;65(12):1266-70. (PMID: 26627505)
J Cell Biochem. 2019 Jan;120(1):425-438. (PMID: 30191607)
Acta Pharmacol Sin. 2020 Jan;41(1):73-81. (PMID: 31427695)
J Ethnopharmacol. 2018 Oct 28;225:71-80. (PMID: 29960023)
BMC Endocr Disord. 2019 Jun 3;19(1):55. (PMID: 31159801)
Molecules. 2019 Feb 16;24(4):. (PMID: 30781526)
Eur J Pharmacol. 2020 Jul 5;878:173103. (PMID: 32278854)
Metabolism. 2019 Mar;92:6-10. (PMID: 30253139)
BMC Res Notes. 2017 Jul 26;10(1):331. (PMID: 28747209)
Molecules. 2014 Dec 22;19(12):21560-78. (PMID: 25532849)
Free Radic Biol Med. 2019 Jan;130:478-488. (PMID: 30447350)
Arch Biochem Biophys. 2018 May 15;646:55-63. (PMID: 29608879)
BMC Complement Altern Med. 2017 Jul 18;17(1):372. (PMID: 28720134)
J Tradit Complement Med. 2013 Apr;3(2):88-94. (PMID: 24716162)
J Pineal Res. 2006 Aug;41(1):79-84. (PMID: 16842545)
Clin Exp Pharmacol Physiol. 2012 Jun;39(6):551-9. (PMID: 22524969)
J Ethnopharmacol. 2020 May 10;253:112645. (PMID: 32045684)
ScientificWorldJournal. 2013 Dec 29;2013:162750. (PMID: 24470791)
J Diabetes Investig. 2020 May;11(3):532-534. (PMID: 32232972)
J Physiol Biochem. 2019 Feb;75(1):83-88. (PMID: 30539499)
Food Chem. 2018 Jul 30;255:414-420. (PMID: 29571495)
J Nutr Biochem. 2022 Jan;99:108840. (PMID: 34419569)
J Lipid Res. 2000 Dec;41(12):1969-79. (PMID: 11108730)
Front Endocrinol (Lausanne). 2021 May 18;12:585887. (PMID: 34084149)
Front Nutr. 2017 Jan 03;3:57. (PMID: 28097121)
J Nutr Biochem. 2015 Sep;26(9):938-48. (PMID: 26025327)
J Tradit Complement Med. 2021 Jul 18;12(2):131-140. (PMID: 35528469)
J Arrhythm. 2017 Jun;33(3):220-225. (PMID: 28607618)
Anal Bioanal Chem. 2005 Nov;383(5):787-96. (PMID: 16237543)
Metabolomics. 2013 Jun;9(3):599-607. (PMID: 23678344)
Foods. 2019 Jul 05;8(7):. (PMID: 31284512)
Oxid Med Cell Longev. 2015;2015:181260. (PMID: 26180580)
Phytomedicine. 2012 Sep 15;19(12):1059-67. (PMID: 22884305)
Sci Rep. 2019 Dec 27;9(1):20026. (PMID: 31882854)
Endocrinology. 2012 Dec;153(12):5866-74. (PMID: 23117929)
Transl Res. 2016 Jan;167(1):228-56. (PMID: 26408801)
EJIFCC. 2017 Mar 08;28(1):6-24. (PMID: 28439216)
Life Sci. 2017 May 01;176:75-81. (PMID: 28302561)
Heliyon. 2019 Aug 09;5(8):e02274. (PMID: 31440603)
Cell Rep. 2017 Feb 21;18(8):2030-2044. (PMID: 28228267)
Phytomedicine. 2019 Nov;64:153074. (PMID: 31473580)
Life Sci. 2019 Mar 15;221:327-334. (PMID: 30797018)
Diabetologia. 1985 Jul;28(7):412-9. (PMID: 3899825)
Food Funct. 2019 Jan 22;10(1):203-215. (PMID: 30525169)
Diabetes Metab Syndr. 2019 Mar - Apr;13(2):1137-1140. (PMID: 31336456)
Arch Biochem Biophys. 2016 Jun 1;599:13-21. (PMID: 26968772)
Biomed Pharmacother. 2017 Feb;86:292-296. (PMID: 28011376)
فهرسة مساهمة: Keywords: A. nilotica; Inflammatory cytokines; Insulin resistance; Obesity; Oxidative stress
تواريخ الأحداث: Date Created: 20230703 Latest Revision: 20230704
رمز التحديث: 20230704
مُعرف محوري في PubMed: PMC10310866
DOI: 10.1016/j.jtcme.2023.03.005
PMID: 37396158
قاعدة البيانات: MEDLINE
الوصف
تدمد:2225-4110
DOI:10.1016/j.jtcme.2023.03.005