دورية أكاديمية
Association of physical activity and sitting with metabolic syndrome and hyperglycemic clamp parameters in adolescents - BRAMS pediatric study.
| العنوان: | Association of physical activity and sitting with metabolic syndrome and hyperglycemic clamp parameters in adolescents - BRAMS pediatric study. |
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| المؤلفون: | Silva TO; Laboratory of Diabetes and Metabolism Investigation (LIMED), School of Medical Sciences of the State University of Campinas (FCM-UNICAMP), Campinas, SP, Brazil., Norde MM; Laboratory of Diabetes and Metabolism Investigation (LIMED), School of Medical Sciences of the State University of Campinas (FCM-UNICAMP), Campinas, SP, Brazil., Vasques AC; Laboratory of Diabetes and Metabolism Investigation (LIMED), School of Medical Sciences of the State University of Campinas (FCM-UNICAMP), Campinas, SP, Brazil., Zambom MP; Department of Pediatrics, FCM-UNICAMP, Campinas, SP, Brazil., Antonio MARGM; Department of Pediatrics, FCM-UNICAMP, Campinas, SP, Brazil., Rodrigues AMB; School of Health and Life Sciences, Nossa Senhora do Patrocinio University, Itu, SP, Brazil., Geloneze B; Laboratory of Diabetes and Metabolism Investigation (LIMED), School of Medical Sciences of the State University of Campinas (FCM-UNICAMP), Campinas, SP, Brazil. |
| مؤلفون مشاركون: | BRAMS group, Brazilian Metabolic Syndrome Study investigators |
| المصدر: | Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2023 Jun 15; Vol. 14, pp. 1191935. Date of Electronic Publication: 2023 Jun 15 (Print Publication: 2023). |
| نوع المنشور: | Multicenter Study; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101555782 Publication Model: eCollection Cited Medium: Print ISSN: 1664-2392 (Print) Linking ISSN: 16642392 NLM ISO Abbreviation: Front Endocrinol (Lausanne) Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Lausanne : Frontiers Research Foundation] |
| مواضيع طبية MeSH: | Metabolic Syndrome* , Insulin Resistance*/physiology, Humans ; Adolescent ; Child ; Cross-Sectional Studies ; Obesity/complications ; Lipids ; Exercise |
| مستخلص: | Introduction: Obesity and metabolic syndrome (MetS) have immediate and long-term consequences on adolescent health and well-being. Among the available treatments for MetS in adolescents, behavioral interventions such as increasing physical activity (PA) are preferred. This study aimed to investigate the association of PA and sitting time with MetS and a complete set of metabolic health parameters. Methods: Data from the Pediatric Brazilian Metabolic Syndrome Study (BRAMS-P), a cross-sectional multicenter study conducted using a convenience sample of 448 Brazilian adolescents (10y-19y), were used. Sociodemographic and lifestyle information were collected using a standardized questionnaire. Daily PA and sitting time were estimated from the International PA Questionnaire. Anthropometric parameters, body composition, and blood pressure were measured by trained researchers. Blood lipids, uric acid, hepatic enzymes, creatinine, glycated hemoglobin, glucose, and insulin were measured in fasting blood samples, and the Homeostasis Model Assessment for Insulin Resistance was calculated. A subsample of 57 adolescents underwent the hyperglycemic clamp protocol. Results: The odds for metabolic syndrome were higher among adolescents who spent >8h sitting (OR (95%CI)=2.11 (1.02 - 4.38)), but not in those classified as active (OR (95%CI)=0.98 (0.42 - 2.26)). Adolescents who spent more time sitting had higher BMI, waist circumference, sagittal abdominal diameter, neck circumference, percentage of body fat, and worse blood lipid profile. The insulin sensitivity index was moderately and positively correlated with moderate-to-high PA in minutes per day (rho=0.29; p=0.047). Conclusion: Time spent sitting was associated with worse metabolic parameters and must be restricted in favor of adolescent health. Regular PA is associated with improved insulin sensitivity and may be encouraged not only in adolescents with obesity or metabolic disorders but also to prevent adverse metabolic outcomes in normal-weight adolescents. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Silva, Norde, Vasques, Zambom, Antonio, Rodrigues, BRAMS group, Geloneze and Brazilian Metabolic Syndrome Study investigators.) |
| References: | Eur J Epidemiol. 2021 Mar;36(3):275-285. (PMID: 33428024) Vital Health Stat 11. 2002 May;(246):1-190. (PMID: 12043359) Front Endocrinol (Lausanne). 2019 Oct 15;10:702. (PMID: 31681173) Arch Endocrinol Metab. 2023 Jan 18;67(1):119-125. (PMID: 36468919) Diabetes Metab Syndr. 2022 Jun;16(6):102530. (PMID: 35709585) Br J Sports Med. 2020 Dec;54(24):1451-1462. (PMID: 33239350) Int J Behav Nutr Phys Act. 2020 Nov 26;17(1):141. (PMID: 33239009) Pediatr Diabetes. 2018 Aug;19(5):882-891. (PMID: 29573519) JAMA Pediatr. 2016 May 1;170(5):487-94. (PMID: 26999405) Horm Res. 2005;64 Suppl 3:16-24. (PMID: 16439840) Diabetes. 2012 Nov;61(11):2787-95. (PMID: 22751691) Diabetes Res Clin Pract. 2018 Mar;137:72-82. (PMID: 29320718) J Clin Invest. 2016 Jan;126(1):12-22. (PMID: 26727229) Eur J Prev Cardiol. 2019 May;26(7):701-708. (PMID: 30317879) J Appl Physiol (1985). 1986 Apr;60(4):1327-32. (PMID: 3700310) Nutrients. 2022 Apr 29;14(9):. (PMID: 35565836) Clin Endocrinol (Oxf). 2013 Jun;78(6):874-81. (PMID: 22804918) PLoS One. 2016 Jun 10;11(6):e0157240. (PMID: 27285386) Cien Saude Colet. 2018 Aug;23(8):2575-2585. (PMID: 30137127) Nutrients. 2022 Nov 11;14(22):. (PMID: 36432462) Obes Rev. 2022 Dec;23(12):e13510. (PMID: 36261077) Obes Rev. 2019 Jan;20(1):55-74. (PMID: 30270500) Lancet. 2022 Jan 8;399(10320):172-184. (PMID: 34856190) J Adolesc Health. 2022 Jun;70(6):950-960. (PMID: 35177343) Arq Bras Cardiol. 2005 Aug;85(2):79-81. (PMID: 16113843) Lancet Diabetes Endocrinol. 2022 May;10(5):351-365. (PMID: 35248172) Bull World Health Organ. 2007 Sep;85(9):660-7. (PMID: 18026621) J Pediatr Endocrinol Metab. 2018 Jan 26;31(1):63-69. (PMID: 29329105) J Allied Health. 2013 Winter;42(4):236-42. (PMID: 24326921) Horm Res Paediatr. 2012;78(5-6):269-78. (PMID: 23208318) Lancet Child Adolesc Health. 2022 Mar;6(3):158-170. (PMID: 35051409) Curr Obes Rep. 2021 Sep;10(3):301-310. (PMID: 33950400) Diabetologia. 1985 Jul;28(7):412-9. (PMID: 3899825) Pediatr Diabetes. 2007 Oct;8(5):299-306. (PMID: 17850473) Int J Environ Res Public Health. 2023 Feb 13;20(4):. (PMID: 36833968) |
| فهرسة مساهمة: | Keywords: adolescents; hyperglycemic clamp; international physical activity questionnaire; metabolic syndrome; physical activity; sitting |
| المشرفين على المادة: | 0 (Lipids) |
| تواريخ الأحداث: | Date Created: 20230703 Date Completed: 20230705 Latest Revision: 20230705 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC10310946 |
| DOI: | 10.3389/fendo.2023.1191935 |
| PMID: | 37396186 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1664-2392 |
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| DOI: | 10.3389/fendo.2023.1191935 |