دورية أكاديمية
أعرض في EDS

Circulating microbial cell-free DNA is increased during neutropenia after hematopoietic stem cell transplantation.

التفاصيل البيبلوغرافية
العنوان: Circulating microbial cell-free DNA is increased during neutropenia after hematopoietic stem cell transplantation.
المؤلفون: Blair LM; Karius, Inc, Redwood City, CA., Akhund-Zade J; Karius, Inc, Redwood City, CA., Katsamakis ZA; Department of Medicine, Adult Bone Marrow Transplantation Service, Memorial Sloan Kettering Cancer Center, New York, NY., Smibert OC; Department of Infectious Diseases, Austin Health, Heidelberg, VIC, Australia.; Department of Infectious Diseases, Peter McCallum Cancer Centre, Melbourne, VIC, Australia.; National Centre for Infections in Cancer, Peter McCallum Cancer Centre, Melbourne, VIC, Australia., Wolfe AE; Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA., Giardina P; Department of Medicine, Adult Bone Marrow Transplantation Service, Memorial Sloan Kettering Cancer Center, New York, NY., Slingerland J; Department of Medicine, Adult Bone Marrow Transplantation Service, Memorial Sloan Kettering Cancer Center, New York, NY., Bercovici S; Karius, Inc, Redwood City, CA., Perales MA; Department of Medicine, Adult Bone Marrow Transplantation Service, Memorial Sloan Kettering Cancer Center, New York, NY.; Department of Medicine Weill Cornell Medical College, New York, NY., Taur Y; Department of Medicine, Infectious Disease Service, Memorial Sloan Kettering Cancer Center, New York, NY., van den Brink MRM; Department of Medicine, Adult Bone Marrow Transplantation Service, Memorial Sloan Kettering Cancer Center, New York, NY.; Department of Medicine Weill Cornell Medical College, New York, NY.; Immunology Program, Sloan Kettering Institute, New York, NY., Peled JU; Department of Medicine, Adult Bone Marrow Transplantation Service, Memorial Sloan Kettering Cancer Center, New York, NY.; Department of Medicine Weill Cornell Medical College, New York, NY., Markey KA; Department of Medicine, Adult Bone Marrow Transplantation Service, Memorial Sloan Kettering Cancer Center, New York, NY.; Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA.; Division of Medicine, University of Washington, Seattle, WA.
المصدر: Blood advances [Blood Adv] 2023 Nov 14; Vol. 7 (21), pp. 6744-6750.
نوع المنشور: Observational Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: American Society of Hematology Country of Publication: United States NLM ID: 101698425 Publication Model: Print Cited Medium: Internet ISSN: 2473-9537 (Electronic) Linking ISSN: 24739529 NLM ISO Abbreviation: Blood Adv Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Washington, DC : American Society of Hematology, [2016]-
مواضيع طبية MeSH: Cell-Free Nucleic Acids* , Graft vs Host Disease*/etiology , Hematopoietic Stem Cell Transplantation*/adverse effects , Neoplasms*/complications , Neutropenia*, Humans
مستخلص: We used a next-generation sequencing platform to characterize microbial cell-free DNA (mcfDNA) in plasma samples from patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HCT). In this observational study, we sought to characterize plasma mcfDNA in order to explore its potential association with the immunologic complications of transplantation. We compared serially collected patient samples with plasma collected from healthy control subjects. We observed changes in total mcfDNA burden in the plasma after transplantation, which was most striking during the early posttransplant neutropenic phase. This elevation could be attributed to a number of specific bacterial taxa, including Veillonella, Bacteroides, and Prevotella (genus level). For an additional cohort of patients, we compared the data of mcfDNA from plasma with 16s-ribosomal RNA sequencing data from stool samples collected at matched time points. In a number of patients, we confirmed that mcfDNA derived from specific microbial taxa (eg, Enterococcus) could also be observed in the matched stool sample. Quantification of mcfDNA may generate novel insights into mechanisms by which the intestinal microbiome influences systemic cell populations and, thus, has been associated with outcomes for patients with cancer.
(© 2023 by The American Society of Hematology. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0), permitting only noncommercial, nonderivative use with attribution. All other rights reserved.)
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معلومات مُعتمدة: P01 CA023766 United States CA NCI NIH HHS; R01 CA228308 United States CA NCI NIH HHS; U01 AI124275 United States AI NIAID NIH HHS; R01 HL125571 United States HL NHLBI NIH HHS; R01 CA228358 United States CA NCI NIH HHS; K08 HL143189 United States HL NHLBI NIH HHS; R01 HL123340 United States HL NHLBI NIH HHS; P30 CA008748 United States CA NCI NIH HHS; P01 AG052359 United States AG NIA NIH HHS
المشرفين على المادة: 0 (Cell-Free Nucleic Acids)
تواريخ الأحداث: Date Created: 20230703 Date Completed: 20231103 Latest Revision: 20240426
رمز التحديث: 20240426
مُعرف محوري في PubMed: PMC10651422
DOI: 10.1182/bloodadvances.2023010208
PMID: 37399491
قاعدة البيانات: MEDLINE
الوصف
تدمد:2473-9537
DOI:10.1182/bloodadvances.2023010208