دورية أكاديمية
أعرض في EDS

Proapoptotic effects of halogenated bis-phenylthiourea derivatives in cancer cells.

التفاصيل البيبلوغرافية
العنوان: Proapoptotic effects of halogenated bis-phenylthiourea derivatives in cancer cells.
المؤلفون: Strzyga-Łach P; Chair and Department of Biochemistry, Medical University of Warsaw, Warsaw, Poland., Chrzanowska A; Chair and Department of Biochemistry, Medical University of Warsaw, Warsaw, Poland., Kiernozek-Kalińska E; Department of Immunology, Faculty of Biology, University of Warsaw, Warsaw, Poland., Żyżyńska-Granica B; Chair and Department of Biochemistry, Medical University of Warsaw, Warsaw, Poland., Podsadni K; Chair and Department of Biochemistry, Medical University of Warsaw, Warsaw, Poland., Podsadni P; Department of Drug Technology and Pharmaceutical Biotechnology, Faculty of Pharmacy, Medical University of Warsaw, Warsaw, Poland., Bielenica A; Chair and Department of Biochemistry, Medical University of Warsaw, Warsaw, Poland.
المصدر: Archiv der Pharmazie [Arch Pharm (Weinheim)] 2023 Sep; Vol. 356 (9), pp. e2300105. Date of Electronic Publication: 2023 Jul 04.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley-VCH Verlag GmbH & Co. KGaA Country of Publication: Germany NLM ID: 0330167 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-4184 (Electronic) Linking ISSN: 03656233 NLM ISO Abbreviation: Arch Pharm (Weinheim) Subsets: MEDLINE
أسماء مطبوعة: Publication: <2005->: Weinheim Germany : Wiley-VCH Verlag GmbH & Co. KGaA
Original Publication: Weinheim, Verlag Chemie GmbH.
مواضيع طبية MeSH: Antineoplastic Agents*/pharmacology , Neoplasms*, Caspase 3/metabolism ; Caspase 7/metabolism ; Structure-Activity Relationship ; Phenylthiourea/pharmacology ; Reactive Oxygen Species/metabolism ; Interleukin-6/pharmacology ; Cell Line, Tumor ; Apoptosis ; Cell Proliferation
مستخلص: New halogenated thiourea derivatives were synthesized via the reaction of substituted phenylisothiocyanates with aromatic amines. Their cytotoxic activity was examined in in vitro studies against solid tumors (SW480, SW620, PC3), a hematological malignance (K-562), and normal keratinocytes (HaCaT). Most of the compounds were more effective against SW480 (1a, 3a, 3b, 5j), K-562 (2b, 3a, 4a), or PC3 (5d) cells than cisplatin, with favorable selectivity. Their anticancer mechanisms were studied by Annexin V-fluorescein-5-isothiocyanate apoptosis, caspase-3/caspase-7 assessment, cell cycle analysis, interleukin-6 (IL-6) release inhibition, and reactive oxygen species (ROS) generation assay. Thioureas 1a, 2b, 3a, and 4a were the most potent activators of early apoptosis in K-562 cells, and substances 1a, 3b, 5j triggered late-apoptosis or necrosis in SW480 cells. This proapoptotic effect was proved by the significant increase of caspase-3/caspase-7 activation. Cell cycle analysis revealed that derivatives 1a, 3a, 5j increased the number of SW480 and K-562 cells in the sub-G1 and/or G0/G1 phases, and one evoked cycle arrest at the G2 phase. The most potent thioureas inhibited IL-6 cytokine secretion from PC3 cells and both colon cancer cell lines. Apoptosis-inducing compounds also increased ROS production in all tumor cell cultures, which may enhance their anticancer properties.
(© 2023 Deutsche Pharmazeutische Gesellschaft.)
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معلومات مُعتمدة: Warszawski Uniwersytet Medyczny
فهرسة مساهمة: Keywords: apoptosis; caspase-3/caspase-7 activation; cell cycle analysis; cytotoxic activity; thiourea derivatives
المشرفين على المادة: EC 3.4.22.- (Caspase 3)
EC 3.4.22.- (Caspase 7)
6F82C6Q54C (Phenylthiourea)
0 (Reactive Oxygen Species)
0 (Interleukin-6)
0 (Antineoplastic Agents)
تواريخ الأحداث: Date Created: 20230704 Date Completed: 20230904 Latest Revision: 20230904
رمز التحديث: 20231215
DOI: 10.1002/ardp.202300105
PMID: 37401845
قاعدة البيانات: MEDLINE
الوصف
تدمد:1521-4184
DOI:10.1002/ardp.202300105