دورية أكاديمية
COVID-19 in the nervous system: physiopathology and neurological manifestations.
العنوان: | COVID-19 in the nervous system: physiopathology and neurological manifestations. |
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عنوان ترانسليتريتد: | Covid-19 no sistema nervoso: fisiopatologia e manifestações neurológicas. |
المؤلفون: | Mendonça Filho VCM; Universidade Federal do Ceará, Faculdade de Medicina de Sobral, Sobral CE, Brazil., de Oliveira AG; Universidade Federal do Ceará, Faculdade de Medicina de Sobral, Sobral CE, Brazil., Maia IFVC; Universidade Federal do Ceará, Faculdade de Farmácia, Odontologia e Enfermagem, Fortaleza CE, Brazil., de Falcone ACM; Universidade de São Paulo, Faculdade de Medicina, Hospital das Clínicas, São Paulo SP, Brazil., Betini BG; Universidade de São Paulo, Faculdade de Medicina, Hospital das Clínicas, Departamento de Neurologia, Ribeirão Preto SP, Brazil., Rezende LB; Universidade Federal de Minas Gerais, Hospital das Clínicas, Belo Horizonte MG, Brazil., Magri Alves FH; Universidade de São Paulo, Faculdade de Medicina, Hospital das Clínicas, São Paulo SP, Brazil. |
المصدر: | Arquivos de neuro-psiquiatria [Arq Neuropsiquiatr] 2023 Aug; Vol. 81 (8), pp. 756-763. Date of Electronic Publication: 2023 Jul 04. |
نوع المنشور: | Review; Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Thieme Country of Publication: Germany NLM ID: 0125444 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1678-4227 (Electronic) Linking ISSN: 0004282X NLM ISO Abbreviation: Arq Neuropsiquiatr Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 2022- : [Stuttgart] : Thieme Original Publication: São Paulo. |
مواضيع طبية MeSH: | COVID-19*/complications , COVID-19*/pathology , Nervous System Diseases*/etiology, Humans ; SARS-CoV-2 ; Central Nervous System ; Brain/pathology |
مستخلص: | Background: Coronavirus disease 2019 (COVID-19) is a viral infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although respiratory manifestations have received greater visibility during the pandemic caused by this virus, numerous neurological complaints related to coronavirus 2 infection have been documented in several countries. These records suggest that this pathogen presents neurotropism, and it can cause different neurological conditions of varying intensity. Objective: To investigate the ability of coronavirus 2 to invade the central nervous system (CNS) and its neurological clinical outcomes. Methods: The present study consists in a comprehensive literature review of the records available in the PubMed, SciELO, and Google Scholar databases. The descriptors COVID-19 , brain and physiopathology , associated with the Boolean operator AND , were used in the search. Regarding the inclusion and exclusion criteria, we selected the papers published since 2020 with the highest number of citations. Results: We selected 41 articles, most of them in English. The main clinical manifestation associated with COVID-19 patients was headache, but cases of anosmia, hyposmia, Guillain-Barré syndrome, and encephalopathies were also described with considerable frequency. Conclusion: Coronavirus-2 presents neurotropism, and it can reach the CNS by hematogenous dissemination and by direct infection of the nerve endings. It causes brain injuries through several mechanisms, such as cytokine storm, microglial activation, and an increase in thrombotic factors. Competing Interests: The authors have no conflict of interest to declare. (Academia Brasileira de Neurologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/).) |
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فهرسة مساهمة: | Local Abstract: [Publisher, Portuguese] A doença do coronavírus 2019 ( coronavirus disease 2019 , Covid-19, em inglês) é uma infecção viral provocada pelo coronavírus 2 da síndrome respiratória aguda grave ( severe acute respiratory syndrome coronavirus 2 , SARS-CoV-2, em inglês). Embora as manifestações respiratórias tenham recebido maior visibilidade ao longo da pandemia provocada por esse vírus, inúmeras queixas neurológicas relacionadas à infecção pelo coronavírus 2 foram documentadas em diversos países. Tais registros sugerem que esse patógeno apresenta neurotropismo, e é capaz de provocar quadros neurológicos diversos e de intensidade variáveis. [Publisher, Portuguese] Investigar a capacidade de invasão do sistema nervoso central (SNC) pelo coronavírus 2 e seus principais desfechos clínicos neurológicos. MéTODOS: O presente estudo consiste em uma ampla revisão de literatura a partir dos registros das bases de dados PubMed, SciELO e Google Acadêmico. Nesse contexto, os descritores COVID-19 , cérebro e fisiopatologia , associados com o operador booleano AND , foram utilizados na busca. Quanto aos critérios de inclusão e exclusão, selecionou-se os trabalhos publicados a partir de 2020 com o maior número de citações. [Publisher, Portuguese] Foram selecionados 41 artigos, a maioria na língua inglesa. A principal manifestação clínica associada a pacientes acometidos pela COVID-19 foi a cefaleia, mas casos de anosmia, hiposmia, síndrome de Guillain-Barré e encefalopatias também foram descritos com frequência considerável. CONCLUSãO: O coronavírus 2 apresenta neurotropismo, e é capaz de alcançar o SNC por disseminação hematogênica e por infecção direta das terminações nervosas. Ele provoca injúria cerebral por meio de variados mecanismos, como tempestade de citocinas, ativação da micróglia e aumento dos fatores trombóticos. |
تواريخ الأحداث: | Date Created: 20230704 Date Completed: 20230901 Latest Revision: 20230902 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC10468725 |
DOI: | 10.1055/s-0043-1769123 |
PMID: | 37402400 |
قاعدة البيانات: | MEDLINE |
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