دورية أكاديمية
Natural history and clinical burden of moderate aortic stenosis: a systematic review and explorative meta-analysis.
| العنوان: | Natural history and clinical burden of moderate aortic stenosis: a systematic review and explorative meta-analysis. |
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| المؤلفون: | Morelli M; School of Medicine and Surgery, University of Milano-Bicocca., Galasso M; School of Medicine and Surgery, University of Milano-Bicocca., Esposito G; Interventional Cardiology, 1 Division of Cardiology, De Gasperis Cardio Center, Niguarda Hospital., Soriano FS; Interventional Cardiology, 1 Division of Cardiology, De Gasperis Cardio Center, Niguarda Hospital., Nava S; Interventional Cardiology, 1 Division of Cardiology, De Gasperis Cardio Center, Niguarda Hospital., Da Pozzo C; School of Medicine and Surgery, University of Milan., Bossi I; Interventional Cardiology, 1 Division of Cardiology, De Gasperis Cardio Center, Niguarda Hospital., Piccaluga E; Interventional Cardiology, 1 Division of Cardiology, De Gasperis Cardio Center, Niguarda Hospital., Bruschi G; Department of Cardiac Surgery., Maloberti A; School of Medicine and Surgery, University of Milano-Bicocca.; 4 Division of Cardiology, De Gasperis Cardio Center, Niguarda Hospital, Milan, Italy., Oliva F; Interventional Cardiology, 1 Division of Cardiology, De Gasperis Cardio Center, Niguarda Hospital., Oreglia JA; Interventional Cardiology, 1 Division of Cardiology, De Gasperis Cardio Center, Niguarda Hospital., Giannattasio C; School of Medicine and Surgery, University of Milano-Bicocca.; 4 Division of Cardiology, De Gasperis Cardio Center, Niguarda Hospital, Milan, Italy., Montalto C; Interventional Cardiology, 1 Division of Cardiology, De Gasperis Cardio Center, Niguarda Hospital. |
| المصدر: | Journal of cardiovascular medicine (Hagerstown, Md.) [J Cardiovasc Med (Hagerstown)] 2023 Sep 01; Vol. 24 (9), pp. 659-665. Date of Electronic Publication: 2023 Jun 26. |
| نوع المنشور: | Systematic Review; Meta-Analysis; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 101259752 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1558-2035 (Electronic) Linking ISSN: 15582027 NLM ISO Abbreviation: J Cardiovasc Med (Hagerstown) Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Hagerstown, MD : Lippincott Williams & Wilkins, c2006- |
| مواضيع طبية MeSH: | Ventricular Function, Left* , Aortic Valve Stenosis*/diagnostic imaging , Aortic Valve Stenosis*/surgery , Aortic Valve Stenosis*/complications, Humans ; Stroke Volume ; Prognosis ; Aortic Valve ; Treatment Outcome ; Retrospective Studies ; Risk Factors |
| مستخلص: | Aims: The mortality risk of patients with moderate aortic stenosis is not well known, but recent studies suggested that it might negatively affect prognosis. We aimed to assess the natural history and clinical burden of moderate aortic stenosis and to investigate the interaction of patients' baseline characteristics with prognosis. Methods: Systematic research was conducted on PubMed. The inclusion criteria were inclusion of patients with moderate aortic stenosis; and report of the survival at 1-year follow-up (minimum). Incidence ratios related to all-cause mortality in patients and controls of each study were estimated and then pooled using a fixed effects model. All patients with mild aortic stenosis or without aortic stenosis were considered controls. Meta-regression analysis was performed to assess the impact of left ventricular ejection fraction and age on the prognosis of patients with moderate aortic stenosis. Results: Fifteen studies and 11 596 patients with moderate aortic stenosis were included. All-cause mortality was significantly higher among patients with moderate aortic stenosis than in controls in all timeframes analysed (all P < 0.0001). Left ventricular ejection fraction and sex did not significantly impact on the prognosis of patients with moderate aortic stenosis ( P = 0.4584 and P = 0.5792), while increasing age showed a significant interaction with mortality (estimate = 0.0067; 95% confidence interval: 0.0007-0.0127; P = 0.0323). Conclusion: Moderate aortic stenosis is associated with reduced survival. Further studies are necessary to confirm the prognostic impact of this valvulopathy and the possible benefit of aortic valve replacement. (Copyright © 2023 Italian Federation of Cardiology - I.F.C. All rights reserved.) |
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| تواريخ الأحداث: | Date Created: 20230706 Date Completed: 20230823 Latest Revision: 20240201 |
| رمز التحديث: | 20240201 |
| مُعرف محوري في PubMed: | PMC10754483 |
| DOI: | 10.2459/JCM.0000000000001490 |
| PMID: | 37409667 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1558-2035 |
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| DOI: | 10.2459/JCM.0000000000001490 |