دورية أكاديمية
Effects of Bis(imino)acenaphthene (Bian)-Derived Ligands on the Cytotoxicity, DNA Interactions, and Redox Activity of Palladium(II) Bipyridine Complexes.
| العنوان: | Effects of Bis(imino)acenaphthene (Bian)-Derived Ligands on the Cytotoxicity, DNA Interactions, and Redox Activity of Palladium(II) Bipyridine Complexes. |
|---|---|
| المؤلفون: | Komlyagina VI; Nikolaev Institute of Inorganic Chemistry, Siberian Branch of the Russian Academy of Sciences (SB RAS), 3 Acad. Lavrentiev Avenue, Novosibirsk 630090, Russia.; Novosibirsk State University, 1 Pirogov Street, Novosibirsk 630090, Russia., Romashev NF; Nikolaev Institute of Inorganic Chemistry, Siberian Branch of the Russian Academy of Sciences (SB RAS), 3 Acad. Lavrentiev Avenue, Novosibirsk 630090, Russia., Besprozvannykh VK; Drug Discovery Lab, Department of Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Hong Kong SAR 999077, People's Republic of China., Arakelyan J; Drug Discovery Lab, Department of Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Hong Kong SAR 999077, People's Republic of China., Wu C; Drug Discovery Lab, Department of Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Hong Kong SAR 999077, People's Republic of China., Chubarov AS; Novosibirsk State University, 1 Pirogov Street, Novosibirsk 630090, Russia.; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences (SB RAS), 8 Lavrentiev Avenue, Novosibirsk 630090, Russia., Bakaev IV; Nikolaev Institute of Inorganic Chemistry, Siberian Branch of the Russian Academy of Sciences (SB RAS), 3 Acad. Lavrentiev Avenue, Novosibirsk 630090, Russia., Soh YK; Drug Discovery Lab, Department of Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Hong Kong SAR 999077, People's Republic of China., Abramov PA; Nikolaev Institute of Inorganic Chemistry, Siberian Branch of the Russian Academy of Sciences (SB RAS), 3 Acad. Lavrentiev Avenue, Novosibirsk 630090, Russia.; Research School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, Tomsk 634034, Russian Federation., Cheung KL; Drug Discovery Lab, Department of Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Hong Kong SAR 999077, People's Republic of China.; Shun Lee Catholic Secondary School, 7 Shun Chi St, Cha Liu Au, Hong Kong, People's Republic of China., Kompan'kov NB; Nikolaev Institute of Inorganic Chemistry, Siberian Branch of the Russian Academy of Sciences (SB RAS), 3 Acad. Lavrentiev Avenue, Novosibirsk 630090, Russia., Ryadun AA; Nikolaev Institute of Inorganic Chemistry, Siberian Branch of the Russian Academy of Sciences (SB RAS), 3 Acad. Lavrentiev Avenue, Novosibirsk 630090, Russia., Babak MV; Drug Discovery Lab, Department of Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Hong Kong SAR 999077, People's Republic of China., Gushchin AL; Nikolaev Institute of Inorganic Chemistry, Siberian Branch of the Russian Academy of Sciences (SB RAS), 3 Acad. Lavrentiev Avenue, Novosibirsk 630090, Russia. |
| المصدر: | Inorganic chemistry [Inorg Chem] 2023 Jul 24; Vol. 62 (29), pp. 11541-11553. Date of Electronic Publication: 2023 Jul 07. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 0366543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-510X (Electronic) Linking ISSN: 00201669 NLM ISO Abbreviation: Inorg Chem Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Easton, Pa.] American Chemical Society. |
| مواضيع طبية MeSH: | Palladium*/pharmacology , Heterocyclic Compounds*, Acenaphthenes/chemistry ; Acenaphthenes/pharmacology ; Ligands ; DNA ; Oxidation-Reduction |
| مستخلص: | A series of heteroleptic bipyridine Pd(II) complexes based on 1,2-bis[(2,6-diisopropylphenyl)imino]acenaphthene (dpp-Bian) or 1,2-bis[(2,4,6-trimethylphenyl)imino]acenaphthene (tmp-Bian) were prepared. All complexes were fully characterized by spectrochemical methods, and their crystal structures were confirmed by X-ray diffraction analysis. The 72 h stability of heteroleptic bipyridine Pd(II) complexes with Bian ligands under physiological conditions was investigated using 1 H NMR spectroscopy. The anticancer activity of all complexes was assessed in a panel of cancer cell lines in comparison with uncoordinated ligands and clinically used drugs cisplatin and doxorubicin. The ability of the complexes to bind DNA was investigated using several methods, including EtBr replacement assay, density functional theory calculations, circular dichroism spectroscopy, DNA gel electrophoresis, and TUNEL assay. The electrochemical activity of all complexes and the uncoordinated ligands was studied using cyclic voltammetry, and reactive oxygen species production in cancer cells was investigated using confocal microscopy. Heteroleptic bipyridine Pd II -Bian complexes were cytotoxic in a low micromolar concentration range and showed some selectivity toward cancer cells in comparison with noncancerous MRC-5 lung fibroblasts. |
| المشرفين على المادة: | 5TWQ1V240M (Palladium) V8UT1GAC5Y (acenaphthene) 0 (Acenaphthenes) 0 (Ligands) 0 (Heterocyclic Compounds) 9007-49-2 (DNA) |
| تواريخ الأحداث: | Date Created: 20230707 Date Completed: 20230725 Latest Revision: 20230725 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1021/acs.inorgchem.3c01172 |
| PMID: | 37418540 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 1520-510X |
|---|---|
| DOI: | 10.1021/acs.inorgchem.3c01172 |