دورية أكاديمية
Expanding use of the HeartMate 3 ventricular assist device in pediatric and adult patients within the Advanced Cardiac Therapies Improving Outcomes Network (ACTION).
| العنوان: | Expanding use of the HeartMate 3 ventricular assist device in pediatric and adult patients within the Advanced Cardiac Therapies Improving Outcomes Network (ACTION). |
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| المؤلفون: | O'Connor MJ; Division of Cardiology, Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania. Electronic address: oconnorm@chop.edu., Shezad M; Heart Institute, Cincinnati Children's Medical Center, Cincinnati, Ohio., Ahmed H; Heart Center, Seattle Children's Hospital, Seattle, Washington., Amdani S; Pediatric Cardiology, Cleveland Clinic Children's Hospital, Cleveland, Ohio., Auerbach SR; University of Colorado Denver, Anschutz Medical Campus and Children's Hospital Colorado, Aurora, Colorado., Bearl DW; Pediatric Cardiology, Monroe Carell Jr Children's Hospital at Vanderbilt, Nashville, Tennessee., Butto A; Sibley Heart Center, Children's Healthcare of Atlanta, Atlanta, Georgia., Byrnes JW; Division of Pediatric Cardiology, Section of Cardiac Critical Care, University of Alabama at Birmingham, Birmingham, Alabama., Conway J; Congenital Heart Program, Stollery Children's Hospital, Edmonton, Alberta, Canada., Dykes JC; Heart Center, Lucile Salter Packard Children's Hospital Stanford, Palo Alto, California., Glass L; Dell Children's Hospital, University of Texas Health, Austin, Texas., Lantz J; Children's Heart Center, UT Southwestern Medical Center, Dallas, Texas., Law S; Division of Cardiology, Columbia University Medical Center, New York-Presbyterian Morgan Stanley Children's Hospital, New York, New York., Mongé MC; Division of Cardiovascular Surgery, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois., Morales DLS; Heart Institute, Cincinnati Children's Medical Center, Cincinnati, Ohio., Parent JJ; Division of Pediatric Cardiology, Riley Children's Hospital, Indianapolis, Indiana., Peng DM; University of Michigan Congenital Heart Center, C.S. Mott Children's Hospital, Ann Arbor, Michigan., Ploutz MS; Pediatric Cardiology, University of Utah, Primary Children's Hospital, Salt Lake City, Utah., Puri K; Divisions of Pediatric Critical Care Medicine and Cardiology, Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, Texas., Shugh S; Heart Institute, Joe DiMaggio Children's Hospital, Hollywood, Florida., Shwaish NS; Pediatric Cardiology, Loma Linda University, Loma Linda, California., VanderPluym CJ; Department of Cardiology, Boston Children's Hospital, Boston, Massachusetts., Wilkens S; Pediatric Cardiology, University of Louisville, Norton Children's Medical Group, Louisville, Kentucky., Wright L; The Heart Center, Nationwide Children's Hospital, Columbus, Ohio., Zinn MD; UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania., Lorts A; Heart Institute, Cincinnati Children's Medical Center, Cincinnati, Ohio. |
| المصدر: | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation [J Heart Lung Transplant] 2023 Nov; Vol. 42 (11), pp. 1546-1556. Date of Electronic Publication: 2023 Jul 05. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 9102703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-3117 (Electronic) Linking ISSN: 10532498 NLM ISO Abbreviation: J Heart Lung Transplant Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 1999- : New York, NY : Elsevier Original Publication: St. Louis, Mo. : Mosby-Year Book, Inc., c1991- |
| مستخلص: | Background: We report current outcomes in patients supported with the HeartMate 3 (HM3) ventricular assist device in a multicenter learning network. Methods: The Advanced Cardiac Therapies Improving Outcomes Network database was queried for HM3 implants between 12/2017 and 5/2022. Clinical characteristics, postimplant course, and adverse events were collected. Patients were stratified according to body surface area (BSA) (<1.4 m 2 , 1.4-1.8 m 2 , and >1.8 m 2 ) at device implantation. Results: During the study period, 170 patients were implanted with the HM3 at participating network centers, with median age 15.3years; 27.1% were female. Median BSA was 1.68 m 2 ; the smallest patient was 0.73 m 2 (17.7 kg). Most (71.8%) had a diagnosis of dilated cardiomyopathy. With a median support time of 102.5days, 61.2% underwent transplantation, 22.9% remained supported on device, 7.6% died, and 2.4% underwent device explantation for recovery; the remainder had transferred to another institution or transitioned to a different device type. The most common adverse events included major bleeding (20.8%) and driveline infection (12.9%); ischemic and hemorrhagic stroke were encountered in 6.5% and 1.2% of patients, respectively. Patients with BSA <1.4 m 2 had a higher incidence of infection, renal dysfunction, and ischemic stroke. Conclusions: In this updated cohort of predominantly pediatric patients supported with the HM3 ventricular assist device, outcomes are excellent with <8% mortality on device. Device-related adverse events including stroke, infection, and renal dysfunction were more commonly seen in smaller patients, highlighting opportunities for improvements in care. (Copyright © 2023 International Society for the Heart and Lung Transplantation. Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: children; heart failure; mechanical circulatory support; pediatric; ventricular assist device |
| تواريخ الأحداث: | Date Created: 20230707 Latest Revision: 20231013 |
| رمز التحديث: | 20231014 |
| DOI: | 10.1016/j.healun.2023.06.015 |
| PMID: | 37419295 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1557-3117 |
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| DOI: | 10.1016/j.healun.2023.06.015 |