دورية أكاديمية
أعرض في EDS

Therapeutic target of leukotriene B 4 receptors, BLT1 and BLT2: Insights from basic research.

التفاصيل البيبلوغرافية
العنوان: Therapeutic target of leukotriene B 4 receptors, BLT1 and BLT2: Insights from basic research.
المؤلفون: Nakamura M; Department of Bioscience, Graduate School of Life Science, Okayama University of Science, 1-1 Ridai-cho, Kita-ku, Okayama, 700-0005, Japan. Electronic address: moto-nakamura@ous.ac.jp., Shimizu T; Lipid Signaling, National Center for Global Health and Medicine, Tokyo, 162-8655, Japan; Institute of Microbial Chemistry, Tokyo, 141-0021, Japan.
المصدر: Biochimie [Biochimie] 2023 Dec; Vol. 215, pp. 60-68. Date of Electronic Publication: 2023 Jul 07.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 1264604 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1638-6183 (Electronic) Linking ISSN: 03009084 NLM ISO Abbreviation: Biochimie Subsets: MEDLINE
أسماء مطبوعة: Publication: Paris : Editions Scientifiques Elsevier
Original Publication: Paris.
مواضيع طبية MeSH: Leukotriene B4*/genetics , Leukotriene B4*/metabolism , Leukotriene B4*/pharmacology , Arthritis, Rheumatoid*, Mice ; Animals ; Skin/metabolism ; Receptors, Leukotriene B4/genetics ; Receptors, Leukotriene B4/metabolism
مستخلص: Leukotriene B 4 (LTB 4 ) is a lipid mediator rapidly generated from arachidonic acid in response to various stimuli. This lipid mediator exerts its biological activities by binding to cognate receptors. Two LTB 4 receptors have been cloned; BLT1 and BLT2 as a high- and a low-affinity receptors, respectively. In numerous analyses, physiological and pathophysiological importance of LTB 4 and cognate receptors in various diseases has been clarified. For example, disruption of the BLT1 gene or treatment with blockers for this receptor reduced various diseases such as rheumatoid arthritis and bronchial asthma in mice, in contrast BLT2 deficiency facilitated several diseases in the small intestine and the skin. These data support the idea that BLT1 blockers and BLT2 agonists could be useful for the cure of these diseases. Thus, various drugs targeting each receptor are being developed by many pharmaceutical companies. In this review, we focus on our current knowledge of the biosynthesis and physiological roles of LTB 4 through cognate receptors. We further describe the effects of these receptor deficiencies on several pathophysiological conditions, including the potential of LTB 4 receptors as therapeutic targets for the cure of the diseases. Moreover, current information on the structure and post-translational modification of BLT1 and BLT2 is discussed.
Competing Interests: Declaration of competing interest The authors declare no conflict of interest.
(Copyright © 2023 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM). All rights reserved.)
فهرسة مساهمة: Keywords: BLT1; BLT2; Disease; Inflammation; Leukotriene B(4); Phosphorylation; Signaling; Structure
المشرفين على المادة: 1HGW4DR56D (Leukotriene B4)
0 (Receptors, Leukotriene B4)
تواريخ الأحداث: Date Created: 20230709 Date Completed: 20231127 Latest Revision: 20231127
رمز التحديث: 20231215
DOI: 10.1016/j.biochi.2023.06.014
PMID: 37423557
قاعدة البيانات: MEDLINE
الوصف
تدمد:1638-6183
DOI:10.1016/j.biochi.2023.06.014