Targeting hepatitis B vaccine escape using immunogenetics in Bangladeshi infants.
| العنوان: | Targeting hepatitis B vaccine escape using immunogenetics in Bangladeshi infants. |
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| المؤلفون: | Butler-Laporte G; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.; Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Québec, Canada.; Division of Infectious Diseases, McGill University Health Centre, Montréal, Québec, Canada., Auckland K; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom., Noor Z; International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh., Kabir M; International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh., Alam M; International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh., Carstensen T; Wellcome Trust Sanger Institute, University of Cambridge, Hinxton, United Kingdom.; Queen Mary University of London, London, United Kingdom., Wojcik GL; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA., Chong AY; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom., Pomilla C; Wellcome Trust Sanger Institute, University of Cambridge, Hinxton, United Kingdom., Noble JA; Children's Hospital Oakland Research Institute, Oakland, California, USA.; Department of Pediatrics, University of California, San Francisco, California, USA., McDevitt SL; Media Labs, Inc. Alameda, CA, USA., Smits G; National Institute for Public Health and the Environment, Bilthoven, The Netherlands., Wareing S; Microbiology Department, John Radcliffe Hospital, Oxford University NHS Foundation Trust, Oxford, UK., van der Klis FR; National Institute for Public Health and the Environment, Bilthoven, The Netherlands., Jeffery K; Microbiology Department, John Radcliffe Hospital, Oxford University NHS Foundation Trust, Oxford, UK., Kirkpatrick BD; Department of Microbiology and Molecular Genetics, Vaccine Testing Center, University of Vermont College of Medicine, Vermont, USA., Sirima S; Groupe de Recherche Action en Santé (GRAS) 06 BP 10248 Ouagadougou, Burkina Faso., Madhi S; South African Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit, University of the Witwatersrand, Johannesburg, South Africa., Elliott A; Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, UK.; Medical Research Council/Uganda Virus Research Institute and London School of Hygiene & Tropical Medicine Uganda Research Unit, Entebbe, Uganda., Richards JB; Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Québec, Canada.; Department of Human Genetics, McGill University, Montréal, Québec, Canada.; 5 Prime Sciences Inc, Montreal, Quebec, Canada.; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montréal, Québec, Canada.; Department of Twin Research, King's College London, London, United Kingdom., Hill AV; The Jenner Institute, University of Oxford, Oxford, United Kingdom., Duggal P; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA., Sandhu MS; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, United Kingdom., Haque R; International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh., Petri WA Jr; Department of Medicine, Infectious Diseases and International Health, University of Virginia School of Medicine, Charlottesville, Virginia, USA., Mentzer AJ; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom. |
| مؤلفون مشاركون: | PROVIDE authors, Cryptosporidiosis Birth Cohort authors |
| المصدر: | MedRxiv : the preprint server for health sciences [medRxiv] 2023 Jun 29. Date of Electronic Publication: 2023 Jun 29. |
| نوع المنشور: | Preprint |
| اللغة: | English |
| بيانات الدورية: | Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE |
| مستخلص: | Hepatitis B virus (HBV) vaccine escape mutants (VEM) are increasingly described, threatening progress in control of this virus worldwide. Here we studied the relationship between host genetic variation, vaccine immunogenicity and viral sequences implicating VEM emergence. In a cohort of 1,096 Bangladeshi children, we identified human leukocyte antigen (HLA) variants associated with response vaccine antigens. Using an HLA imputation panel with 9,448 south Asian individuals DPB1*04:01 was associated with higher HBV antibody responses (p=4.5×10 -30 ). The underlying mechanism is a result of higher affinity binding of HBV surface antigen epitopes to DPB1*04:01 dimers. This is likely a result of evolutionary pressure at the HBV surface antigen 'a-determinant' segment incurring VEM specific to HBV. Prioritizing pre-S isoform HBV vaccines may tackle the rise of HBV vaccine evasion. Competing Interests: Competing interests: JBR’s institution has received investigator-initiated grant funding from Eli Lilly, GlaxoSmithKline and Biogen for projects unrelated to this research. He is the CEO of 5 Prime Sciences Inc (www.5primesciences.com). |
| معلومات مُعتمدة: | MR/K019708/1 United Kingdom MRC_ Medical Research Council; R01 AI043596 United States AI NIAID NIH HHS; MC_UU_00027/5 United Kingdom MRC_ Medical Research Council; United Kingdom WT_ Wellcome Trust; R37 AI026649 United States AI NIAID NIH HHS |
| فهرسة مساهمة: | Keywords: Genome-wide association studies; escape variants; hepatitis B virus; human leukocyte antigen; major histocompatibility complex; vaccination |
| تواريخ الأحداث: | Date Created: 20230710 Latest Revision: 20240313 |
| رمز التحديث: | 20240313 |
| مُعرف محوري في PubMed: | PMC10327284 |
| DOI: | 10.1101/2023.06.26.23291885 |
| PMID: | 37425840 |
| قاعدة البيانات: | MEDLINE |
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