دورية أكاديمية
Neutralizing activity of Usnic acid and β-cyclodextrins complex against SARS-CoV-2 spike pseudovirus.
| العنوان: | Neutralizing activity of Usnic acid and β-cyclodextrins complex against SARS-CoV-2 spike pseudovirus. |
|---|---|
| المؤلفون: | Rosa L; Department of Public Health and Infectious Diseases, University of Rome La Sapienza, Rome, Italy., Cutone A; Department of Biosciences and Territory, University of Molise, Pesche, Italy., Galla R; Laboratory of Physiology, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy.; Noivita srls, spin-off, Novara, Italy., Uberti F; Laboratory of Physiology, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy., Valenti P; Department of Public Health and Infectious Diseases, University of Rome La Sapienza, Rome, Italy. |
| المصدر: | Natural product research [Nat Prod Res] 2024 Jun; Vol. 38 (12), pp. 2129-2134. Date of Electronic Publication: 2023 Jul 12. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Health Sciences Country of Publication: England NLM ID: 101167924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-6427 (Electronic) Linking ISSN: 14786419 NLM ISO Abbreviation: Nat Prod Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Milton Park, UK : Taylor & Francis Health Sciences, c2003- |
| مواضيع طبية MeSH: | Benzofurans*/pharmacology , Benzofurans*/chemistry , SARS-CoV-2*/drug effects , beta-Cyclodextrins*/chemistry , beta-Cyclodextrins*/pharmacology , Antiviral Agents*/pharmacology , Antiviral Agents*/chemistry , Spike Glycoprotein, Coronavirus*, Vero Cells ; Chlorocebus aethiops ; Animals ; Humans ; COVID-19/virology |
| مستخلص: | The rapid spread of SARS-CoV-2 and its infection severity require an urgent development of antiviral agents. In this respect, Usnic acid (UA), a natural dibenzofuran derivative, exerts antiviral activity against several viruses, though presenting very low solubility and high cytotoxicity. Here, UA was complexed with β-cyclodextrins (β-CDs), a pharmaceutical excipient used to improve drug solubility. The cytotoxic activity, tested on Vero E6 cells, revealed no effect for β-CDs alone whereas significant cytotoxicity for the UA/β-CDs complex was recorded at concentrations ≥ 0.05%. The neutralizing activity towards the fusion of SARS-CoV-2 Spike Pseudovirus showed no effects for β-CDs alone whereas the UA/β-CDs complex, when pre-incubated with the viral particles, efficiently inhibited the Pseudoviral fusion of about 90 and 82% at non-cytotoxic concentrations of 0.03 and 0.01%, respectively. In conclusion, although further evidences are needed to clarify the exact inhibition mechanism, UA/β-CDs complex could be useful in SARS-CoV-2 infection. |
| فهرسة مساهمة: | Keywords: COVID-19; SARS-CoV-2; Usnic acid; antiviral activity; usnic acid and β-cyclodextrins complex |
| المشرفين على المادة: | 0 (usnic acid) 0 (spike protein, SARS-CoV-2) |
| تواريخ الأحداث: | Date Created: 20230712 Date Completed: 20240520 Latest Revision: 20240520 |
| رمز التحديث: | 20240521 |
| DOI: | 10.1080/14786419.2023.2235715 |
| PMID: | 37436919 |
| قاعدة البيانات: | MEDLINE |
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