دورية أكاديمية
أعرض في EDS

Capybara Oil Improves Renal Pathophysiology and Inflammation in Obese Mice.

التفاصيل البيبلوغرافية
العنوان: Capybara Oil Improves Renal Pathophysiology and Inflammation in Obese Mice.
المؤلفون: Pereira PG; Ultrastructure and Tissue Biology Laboratory, Institute of Biology, Rio de Janeiro State University, Boulevard Vinte e Oito de Setembro, 87 Fundos, 3° Andar Vila Isabel, Rio de Janeiro 20551-030, RJ, Brazil., Alves LL; Ultrastructure and Tissue Biology Laboratory, Institute of Biology, Rio de Janeiro State University, Boulevard Vinte e Oito de Setembro, 87 Fundos, 3° Andar Vila Isabel, Rio de Janeiro 20551-030, RJ, Brazil., Ciambarella BT; Ultrastructure and Tissue Biology Laboratory, Institute of Biology, Rio de Janeiro State University, Boulevard Vinte e Oito de Setembro, 87 Fundos, 3° Andar Vila Isabel, Rio de Janeiro 20551-030, RJ, Brazil., Rabelo K; Ultrastructure and Tissue Biology Laboratory, Institute of Biology, Rio de Janeiro State University, Boulevard Vinte e Oito de Setembro, 87 Fundos, 3° Andar Vila Isabel, Rio de Janeiro 20551-030, RJ, Brazil., Nascimento ALR; Ultrastructure and Tissue Biology Laboratory, Institute of Biology, Rio de Janeiro State University, Boulevard Vinte e Oito de Setembro, 87 Fundos, 3° Andar Vila Isabel, Rio de Janeiro 20551-030, RJ, Brazil., Moraes ACN; Electron Microscopy Laboratory of Biology Institute, University of Federal Fluminense, Rio de Janeiro 21040-900, RJ, Brazil., Bernardi A; Inflammation Laboratory, Fiocruz, Rio de Janeiro 21040-900, RJ, Brazil., Guimarães FV; Inflammation Laboratory, Fiocruz, Rio de Janeiro 21040-900, RJ, Brazil., Carvalho GM; Ultrastructure and Tissue Biology Laboratory, Institute of Biology, Rio de Janeiro State University, Boulevard Vinte e Oito de Setembro, 87 Fundos, 3° Andar Vila Isabel, Rio de Janeiro 20551-030, RJ, Brazil., da Silva JFR; Ultrastructure and Tissue Biology Laboratory, Institute of Biology, Rio de Janeiro State University, Boulevard Vinte e Oito de Setembro, 87 Fundos, 3° Andar Vila Isabel, Rio de Janeiro 20551-030, RJ, Brazil., de Carvalho JJ; Ultrastructure and Tissue Biology Laboratory, Institute of Biology, Rio de Janeiro State University, Boulevard Vinte e Oito de Setembro, 87 Fundos, 3° Andar Vila Isabel, Rio de Janeiro 20551-030, RJ, Brazil.
المصدر: Nutrients [Nutrients] 2023 Jun 28; Vol. 15 (13). Date of Electronic Publication: 2023 Jun 28.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI Publishing
مواضيع طبية MeSH: Rodentia* , Kidney Diseases*/drug therapy , Kidney Diseases*/etiology , Kidney Diseases*/metabolism, Mice ; Animals ; Mice, Obese ; Kidney/metabolism ; Inflammation/metabolism ; Oxidative Stress ; Obesity/metabolism ; Fibrosis ; Lipids/pharmacology
مستخلص: Obesity is an inflammatory disease associated with secondary diseases such as kidney disease, which can cause lipotoxicity, inflammation and loss of organ function. Polyunsaturated fatty acids act in the production of lipid mediators and have anti-inflammatory characteristics. In this work, the objective was to evaluate renal histopathology in obese mice and the effects of treatment with capybara oil (CO) (5000 mg/kg/day for 4 weeks). Parameters such as body mass, lipid profile, systolic blood pressure, urinary creatinine and protein excretion, structure and ultrastructure of the renal cortex, fibrosis, tissue inflammation and oxidative stress were analyzed. CO treatment in obese mice showed improvement in the lipid profile and reduction in systolic blood pressure levels, in addition to beneficial remodeling of the renal cortex. Our data demonstrated that CO decreased inflammation, oxidative stress and renal fibrosis, as evidenced by quantifying the expression of TNF-α, IL-10, CAT, SOD, α-SMA and TGF-β. Although treatment with CO did not show improvement in renal function, ultrastructural analysis showed that the treatment was effective in restoring podocytes and pedicels, with restructuring of the glomerular filtration barrier. These results demonstrate, for the first time, that treatment with CO is effective in reducing kidney damage, being considered a promising treatment for obesity.
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معلومات مُعتمدة: E-26/202.995/2018 Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro; 316464/2021-0 National Council for Scientific and Technological Development; Finance Code 001 Coordenação de Aperfeicoamento de Pessoal de Nível Superior
فهرسة مساهمة: Keywords: capybara oil; fibrosis; inflammation; kidney injury; obesity; omega-3
المشرفين على المادة: 0 (Lipids)
تواريخ الأحداث: Date Created: 20230714 Date Completed: 20230717 Latest Revision: 20230718
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC10346293
DOI: 10.3390/nu15132925
PMID: 37447251
قاعدة البيانات: MEDLINE
الوصف
تدمد:2072-6643
DOI:10.3390/nu15132925