دورية أكاديمية
أعرض في EDS

Microbiology sampling in non-cystic fibrosis bronchiectasis cases from northern Alberta.

التفاصيل البيبلوغرافية
العنوان: Microbiology sampling in non-cystic fibrosis bronchiectasis cases from northern Alberta.
المؤلفون: Wagner MJ; Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada., Dimitrov M; Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada., Lam GY; Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.; Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada., Leung W; Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.; Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada., Tyrrell GJ; Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.; Provincial Laboratory for Public Health, Alberta Health Services, Edmonton, Alberta, Canada., Vethanayagam D; Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.; Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.
المصدر: PloS one [PLoS One] 2023 Jul 14; Vol. 18 (7), pp. e0288704. Date of Electronic Publication: 2023 Jul 14 (Print Publication: 2023).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Bronchiectasis*/complications , Cystic Fibrosis*/complications , Cystic Fibrosis*/drug therapy , Pseudomonas Infections*/drug therapy, Humans ; Retrospective Studies ; Alberta/epidemiology ; Sputum/microbiology ; Fibrosis ; Pseudomonas aeruginosa ; Anti-Bacterial Agents/therapeutic use
مستخلص: Non-cystic fibrosis bronchiectasis (NCFB) is a chronic respiratory disease resulting in chronic cough, thick sputum, and lower airway microbial colonization, akin to patients with cystic fibrosis (CF). NCFB is a common, yet under recognized entity which inflicts significant morbidity and mortality particularly to older individuals, with a rising prevalence in the developed world. Given that sputum cultures are a non-invasive method to characterize the lower airway microbiota in NCFB patients, for which pathogenic organisms are associated with worsened outcomes, we sought to characterize the microbiological pattern and clinical outcomes associated with sputum culture in a cohort of NCFB patients from Western Canada. A total of 20 subjects were prospectively recruited from various bronchiectasis clinics across the Greater Edmonton area. A retrospective chart review and a symptoms questionnaire was performed, gathering information not limited to symptoms, comorbidities, exacerbations, hospitalizations, sputum production, and sputum culture results over the prior 5 years. Subjects reported frequent hospitalization alongside a significant burden of symptoms. A large majority of sputum cultures grew pathogenic organisms such as Haemophilus influenzae and Pseudomonas aeruginosa. We also note the considerable waste and inefficiency associated with sputum cultures, outlining areas for which this important diagnostic modality can be improved. Accurate characterization of the airway microbiota alongside efficient delivery of health services are key to ensuring the proper treatment of individuals with NCFB, given their high disease burden and frequent hospitalization.
Competing Interests: The authors have declared that there are no competing interests.
(Copyright: © 2023 Wagner et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
References: Thorax. 2010 Jul;65(7):577. (PMID: 20627912)
J Clin Microbiol. 1977 Nov;6(5):518-27. (PMID: 336644)
Eur Respir J. 2016 Jan;47(1):186-93. (PMID: 26541539)
Breathe (Sheff). 2019 Dec;15(4):286-295. (PMID: 31803263)
Ther Clin Risk Manag. 2005 Sep;1(3):169-79. (PMID: 18360557)
Respir Med. 2016 Aug;117:179-89. (PMID: 27492530)
Thorax. 2019 Jan;74(Suppl 1):1-69. (PMID: 30545985)
Thorax. 2013 Aug;68(8):731-7. (PMID: 23564400)
Respir Med. 2007 Aug;101(8):1633-8. (PMID: 17467966)
Antibiotics (Basel). 2021 Mar 20;10(3):. (PMID: 33804631)
J Clin Microbiol. 2002 Aug;40(8):2791-4. (PMID: 12149331)
PLoS One. 2017 Feb 7;12(2):e0170622. (PMID: 28170403)
NPJ Prim Care Respir Med. 2017 Dec;27(1):18. (PMID: 28270656)
Am J Respir Crit Care Med. 2013 Sep 15;188(6):647-56. (PMID: 23898922)
Chin Med J (Engl). 2015 Oct 20;128(20):2792-7. (PMID: 26481748)
CMAJ. 2017 Jun 19;189(24):E828-E835. (PMID: 28630359)
Can J Infect Dis. 1993 May;4(3):166-9. (PMID: 22346442)
Open Access Maced J Med Sci. 2019 Jun 30;7(12):1926-1930. (PMID: 31406530)
Am J Respir Crit Care Med. 2012 Oct 1;186(7):657-65. (PMID: 22744718)
Am J Respir Crit Care Med. 2013 May 15;187(10):1118-26. (PMID: 23348972)
Sci Rep. 2019 May 3;9(1):6871. (PMID: 31053725)
Am J Clin Pathol. 2007 Jul;128(1):32-4. (PMID: 17580270)
Interact Cardiovasc Thorac Surg. 2011 Dec;13(6):619-25. (PMID: 21979982)
Respir Med. 2020 May;166:105940. (PMID: 32250872)
East Mediterr Health J. 2009 Jul-Aug;15(4):792-9. (PMID: 20187530)
Chest. 2002 May;121(5):1486-92. (PMID: 12006433)
J R Coll Physicians Edinb. 2013;43(2):108-13. (PMID: 23734350)
Chest. 2012 Aug;142(2):432-439. (PMID: 22302301)
Int J Chron Obstruct Pulmon Dis. 2018 Jan 09;13:237-246. (PMID: 29386892)
Front Pediatr. 2018 Dec 18;6:403. (PMID: 30619797)
Eur Respir Rev. 2019 Sep 4;28(153):. (PMID: 31484665)
المشرفين على المادة: 0 (Anti-Bacterial Agents)
تواريخ الأحداث: Date Created: 20230714 Date Completed: 20230717 Latest Revision: 20231116
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10348526
DOI: 10.1371/journal.pone.0288704
PMID: 37450508
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0288704