دورية أكاديمية
أعرض في EDS

Changes in Macrophage Subpopulations in Rat Liver at Different Stages of Experimental Fibrosis.

التفاصيل البيبلوغرافية
العنوان: Changes in Macrophage Subpopulations in Rat Liver at Different Stages of Experimental Fibrosis.
المؤلفون: Lebedeva EI; Vitebsk State Order of Peoples' Friendship Medical University, Vitebsk, Belarus. lebedeva.ya-elenale2013@yandex.ru.
المصدر: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2023 Jun; Vol. 175 (2), pp. 279-285. Date of Electronic Publication: 2023 Jul 21.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: United States NLM ID: 0372557 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-8221 (Electronic) Linking ISSN: 00074888 NLM ISO Abbreviation: Bull Exp Biol Med Subsets: MEDLINE
أسماء مطبوعة: Publication: New York : Springer
Original Publication: New York, Consultants Bureau.
مواضيع طبية MeSH: Liver Cirrhosis, Experimental*/chemically induced, Rats ; Animals ; Rats, Wistar ; Liver/pathology ; Liver Cirrhosis/chemically induced ; Liver Cirrhosis/pathology ; Macrophages/pathology
مستخلص: The number, phenotypic composition, and functional properties of macrophages in the liver of Wistar rats change depending on the stages of fibrosis induced by thioacetamide. In the sinusoidal capillaries of the liver of control rats, CD68 + wing-shaped cells were mainly detected. The number of CD68 + cells at the stages of fibrosis before the process of its transformation into cirrhosis was 2-fold higher (p=0.0000) than in the control. At later terms of the experiment, no significant differences were found. Immunohistochemical method revealed two morphologically different groups of CD68 + cells differing in shape and localization. At all stages of the experiment, round and elongated CD206 + cells of were detected in the sinusoidal capillaries. At the stage of cirrhosis (13 weeks), the number of CD206 + cells was higher than during the third week of the experiment by 3.21 times (p=0.0000). Later, a decrease in the number of CD206 + cells was observed. At the same time, in the portal zones and connective tissue septa around the false hepatic lobules, round CX3CR1 + cells were noted. By the end of the experiment (17 weeks), their number exceeded that on the third week of the experiment by 5.66 times (p=0.0000).
(© 2023. Springer Science+Business Media, LLC, part of Springer Nature.)
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فهرسة مساهمة: Keywords: immunohistochemistry; liver fibrogenesis; macrophages; rats; thioacetamide
تواريخ الأحداث: Date Created: 20230721 Date Completed: 20230728 Latest Revision: 20230728
رمز التحديث: 20231215
DOI: 10.1007/s10517-023-05850-x
PMID: 37477742
قاعدة البيانات: MEDLINE
الوصف
تدمد:1573-8221
DOI:10.1007/s10517-023-05850-x