دورية أكاديمية
GATA-3 expression and its correlation with prognostic factors and survival in canine mammary tumors.
| العنوان: | GATA-3 expression and its correlation with prognostic factors and survival in canine mammary tumors. |
|---|---|
| المؤلفون: | Diniz-Gonçalves GS; Research Center on Mammary Oncology NPqOM/HOSPMEV, Federal University of Bahia, Salvador, Brazil., Hielm-Björkman A; DogRisk Research Group, Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland., da Silva VB; Research Center on Mammary Oncology NPqOM/HOSPMEV, Federal University of Bahia, Salvador, Brazil., Ribeiro LGR; Laboratory of Animal Pathology, Department of Veterinary Medicine, Federal University of Sergipe, São Cristóvão, Brazil., da Costa Vieira-Filho CH; Research Center on Mammary Oncology NPqOM/HOSPMEV, Federal University of Bahia, Salvador, Brazil., Silva LP; Research Center on Mammary Oncology NPqOM/HOSPMEV, Federal University of Bahia, Salvador, Brazil., Barrouin-Melo SM; DogRisk Research Group, Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland.; Department of Veterinary Anatomy, Pathology and Clinics, School of Veterinary Medicine and Zootechny, Federal University of Bahia, Salvador, Brazil., Cassali GD; Laboratory of Comparative Pathology, Department of General Pathology, Federal University of Minas Gerais, Belo Horizonte, Brazil., Damasceno KA; Experimental Pathology Laboratory (LAPEX), Gonçalo Moniz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Salvador, Brazil., Estrela-Lima A; Research Center on Mammary Oncology NPqOM/HOSPMEV, Federal University of Bahia, Salvador, Brazil.; DogRisk Research Group, Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland.; Department of Veterinary Anatomy, Pathology and Clinics, School of Veterinary Medicine and Zootechny, Federal University of Bahia, Salvador, Brazil. |
| المصدر: | Frontiers in veterinary science [Front Vet Sci] 2023 Jul 06; Vol. 10, pp. 1179808. Date of Electronic Publication: 2023 Jul 06 (Print Publication: 2023). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101666658 Publication Model: eCollection Cited Medium: Print ISSN: 2297-1769 (Print) Linking ISSN: 22971769 NLM ISO Abbreviation: Front Vet Sci Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Lausanne : Frontiers Media S.A., [2014]- |
| مستخلص: | Introduction: The transcription factor GATA-3 plays a significant role in mammary gland development and differentiation. Recent studies on human oncology have demonstrated its association with favorable pathologic factors in breast cancer. Canine mammary tumours, proposed as comparative and translational study models, have epidemiological, clinical, biological, and genetic characteristics similar to those of human breast cancers. Methods: Here, we evaluated the frequency of GATA-3 expression in mammary tumors of dogs and its relationship with prognostic factors and survival. Tumor samples were obtained from 40 female dogs and grouped according to histological type into benign tumors ( n = 10), carcinoma in mixed tumors (CMTs) ( n = 20), and aggressive tumors ( n = 10). CMTs were further separated according to histological grade, and data on clinical staging and diagnosis, histopathological grading, and survival rate were collected. Results: GATA-3 and estrogen receptor (ER) expression were higher in benign and well-differentiated carcinomas than in aggressive tumors, which showed greater Ki-67 expression. The expression rate of ER in the studied groups was equivalent to that of GATA-3. We identified a strong positive correlation between GATA-3 and ER expression frequencies and a negative correlation between those of GATA-3 and Ki-67. There were associations between GATA-3 ( p < 0.001), Ki-67 ( p = 0.003), tumor size ( p < 0.001), clinical stage ( p = 0.002), lymph node metastasis ( p < 0.001), and histological grade ( p < 0.001) by univariate survival analysis. The parameters ER ( p = 0.015) and GATA-3 ( p = 0.005) also influenced survival in a multifactorial manner. Discussion: Kaplan-Meier analysis of survival curves validated our previous findings that dogs with GATA-3 expression in ≥79.4% of cells had significantly higher survival rates ( p < 0.001). The performance analysis showed that the expression of GATA-3 in ≥79.4% of cells effectively predicted survival or death in dogs with mammary tumors. Collectively, these results suggest that GATA-3 can be a relevant marker in the study of mammary tumor progression and has potential as a prognosis marker for predicting outcomes in canine mammary tumors. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Diniz-Gonçalves, Hielm-Björkman, da Silva, Ribeiro, da Costa Vieira-Filho, Silva, Barrouin-Melo, Cassali, Damasceno and Estrela-Lima.) |
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| فهرسة مساهمة: | Keywords: breast cancer; canine mammary tumors; prognostic biomarker; survival; transcription factor; tumor progression |
| تواريخ الأحداث: | Date Created: 20230724 Latest Revision: 20230725 |
| رمز التحديث: | 20230725 |
| مُعرف محوري في PubMed: | PMC10356988 |
| DOI: | 10.3389/fvets.2023.1179808 |
| PMID: | 37483298 |
| قاعدة البيانات: | MEDLINE |
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