دورية أكاديمية
Prevalence of tuberculosis/COVID-19 co-infection and factors associated with SARS-CoV-2 infection in pulmonary tuberculosis patients at a respiratory diseases center: a cross-sectional study.
| العنوان: | Prevalence of tuberculosis/COVID-19 co-infection and factors associated with SARS-CoV-2 infection in pulmonary tuberculosis patients at a respiratory diseases center: a cross-sectional study. |
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| المؤلفون: | Mangamba LE; Faculty of Health Sciences, University of Buea, Buea, Cameroon.; Douala Laquintinie Hospital, Douala, Cameroon., Sike CIM; Douala Laquintinie Hospital, Douala, Cameroon.; Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon., Tochie JN; Douala Laquintinie Hospital, Douala, Cameroon., Dalle GN; Douala Laquintinie Hospital, Douala, Cameroon.; Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Douala, Cameroon., Nkouagmi N; Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Douala, Cameroon., Balkissou AD; Faculty of Medicine and Biomedical Sciences of Garoua, University of N´Gaoundéré, Garoua, Cameroon., Bille BE; Douala Laquintinie Hospital, Douala, Cameroon., Ngahane BHM; Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Douala, Cameroon.; Douala General Hospital, Douala, Cameroon., Moukoko CEE; Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Douala, Cameroon.; Malaria Unit, Centre Pasteur Cameroon, Yaoundé, Cameroon. |
| المصدر: | The Pan African medical journal [Pan Afr Med J] 2023 Apr 28; Vol. 44, pp. 204. Date of Electronic Publication: 2023 Apr 28 (Print Publication: 2023). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: African Field Epidemiology Network Country of Publication: Uganda NLM ID: 101517926 Publication Model: eCollection Cited Medium: Internet ISSN: 1937-8688 (Electronic) NLM ISO Abbreviation: Pan Afr Med J Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Kampala, Uganda : African Field Epidemiology Network |
| مواضيع طبية MeSH: | COVID-19*/epidemiology , Coinfection*/epidemiology , Tuberculosis*/epidemiology , Tuberculosis, Pulmonary*/epidemiology , Asthma* , Pharyngitis*, Male ; Humans ; Adult ; Middle Aged ; Female ; SARS-CoV-2 ; Cross-Sectional Studies ; Prospective Studies ; Prevalence ; RNA, Viral ; Cameroon/epidemiology |
| مستخلص: | Introduction: currently, tuberculosis (TB) is the second cause of infectious disease-related deaths before COVID-19. These two infections have several similarities but little data is available on TB/COVID-19 co-infection, hence, we sought to investigate the prevalence of this co-infection and the factors associated with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection in tuberculosis patients in a tuberculosis-endemic area. Methods: we conducted a prospective cross-sectional study from January to June 2022 at Respiratory Diseases Center in Douala, Cameroon by enrolling all consenting pulmonary tuberculosis patients. The presence of SARS-CoV-2 ribonucleic acid (RNA) and gamma-interferon levels were laboratory analyzed using the Reverse Transcriptase-Polymerase Chain Reaction and the enzyme-linked immunosorbent assay (ELISA) technique, respectively. The factors associated with COVID-19 carriage in pulmonary tuberculosis patients were analyzed by logistic regressions. Results: overall, we enrolled 185 patients; 57.8% were males (sex ratio of 1.36) and their mean age was 43.70 ± 17.89 years. The prevalence of SARS-CoV-2 RNA in pulmonary TB patients was 24.3%. Asthma and sore throat were the factors favoring carriage (OR=3.74; 95% CI=1.271-11.017; p=0.017 and OR=4.05; 95%CI=1.204-13.600; p=0.024) and cough was a protective factor (OR=0.15; 95% CI = 0.034-0.690; p=0.015). Conclusion: the prevalence of SARS-CoV-2 carriage in tuberculosis patients is high and greater than the national prevalence. Asthma and sore throat would be associated factors. Competing Interests: The authors declare no competing interests. (Copyright: Laurent-Mireille Endale Mangamba et al.) |
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| فهرسة مساهمة: | Keywords: COVID-19; SARS-CoV-2; carriage; prevalence; tuberculosis |
| المشرفين على المادة: | 0 (RNA, Viral) |
| تواريخ الأحداث: | Date Created: 20230724 Date Completed: 20230725 Latest Revision: 20230725 |
| رمز التحديث: | 20240829 |
| مُعرف محوري في PubMed: | PMC10362651 |
| DOI: | 10.11604/pamj.2023.44.204.38541 |
| PMID: | 37484595 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1937-8688 |
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| DOI: | 10.11604/pamj.2023.44.204.38541 |