دورية أكاديمية
أعرض في EDS

Effect of PI3K/AKT/mTOR signaling pathway-based clustered nursing care combined with papaverine injection on vascular inflammation and vascular crisis after replantation of severed fingers.

التفاصيل البيبلوغرافية
العنوان: Effect of PI3K/AKT/mTOR signaling pathway-based clustered nursing care combined with papaverine injection on vascular inflammation and vascular crisis after replantation of severed fingers.
المؤلفون: Wang N; Department of Hand, Foot and Ankle Surgery, General Hospital of Ningxia Medical University, Yinchuan, China., Xiao H; Outpatient Department of the People's Hospital of Ningxia Hui Autonomous Region, Yinchuan, China., Lu H; Nursing Department, General Hospital of Ningxia Medical University, 804 Shengli South Street, Xingqing District, Yinchuan, 750004, Ningxia, China. txgwh@163.com., Chen K; Department of Hand, Foot and Ankle Surgery, General Hospital of Ningxia Medical University, Yinchuan, China. footckai@163.com., Zhang S; Department of Hepatobiliary Surgery, General Hospital of Ningxia Medical University, Yinchuan, China., Liu F; Department of Hand, Foot and Ankle Surgery, General Hospital of Ningxia Medical University, Yinchuan, China., Zhang N; Department of Hand, Foot and Ankle Surgery, General Hospital of Ningxia Medical University, Yinchuan, China., Zhang H; Department of Hand, Foot and Ankle Surgery, General Hospital of Ningxia Medical University, Yinchuan, China., Chen S; Department of Hand, Foot and Ankle Surgery, General Hospital of Ningxia Medical University, Yinchuan, China., Xu X; Department of Stomatology, General Hospital of Ningxia Medical University, Yinchuan, China.
المصدر: Molecular and cellular biochemistry [Mol Cell Biochem] 2024 Jun; Vol. 479 (6), pp. 1525-1534. Date of Electronic Publication: 2023 Jul 25.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: Netherlands NLM ID: 0364456 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-4919 (Electronic) Linking ISSN: 03008177 NLM ISO Abbreviation: Mol Cell Biochem Subsets: MEDLINE
أسماء مطبوعة: Publication: New York : Springer
Original Publication: The Hague, Dr. W. Junk B. V. Publishers.
مواضيع طبية MeSH: TOR Serine-Threonine Kinases*/metabolism , Proto-Oncogene Proteins c-akt*/metabolism , Papaverine*/pharmacology , Papaverine*/administration & dosage , Signal Transduction*/drug effects , Fingers*/blood supply, Humans ; Male ; Female ; Adult ; Middle Aged ; Replantation ; Phosphatidylinositol 3-Kinases/metabolism ; Finger Injuries/surgery ; Inflammation ; Vasculitis
مستخلص: This research aimed to investigate the effect of PI3K (phosphatidylinositol 3-kinase)/AKT (protein kinase B)/mTOR (mammalian target protein of rapamycin) signaling pathway-based clustering care combined with papaverine injection on vascular inflammation and vascular crisis after finger amputation and replantation. 100 patients admitted in General Hospital of Ningxia Medical University from April 2022 to December 2022 for replantation of severed fingers were selected and divided into a control group (n = 50) and an observation group (n = 50) using the randomized grouping principle. The control group received a papaverine injection and general nursing care, the observation group received a papaverine injection and clustered care. The pain score; constipation incidence; replantation finger survival rate; physician, nurse, and patient satisfaction; serum inflammatory factors; vascular crisis parameters; and occurrence of adverse reactions were compared between the two patient groups. Enzyme-linked immunosorbent assay was performed to detect PI3K, AKT, and mTOR protein concentrations in the venous blood of the two groups, and statistical analysis of the data was performed. On postoperative day 7, the pain score and incidence of constipation in the observation group were lower than those in the control group (P < 0.05); the survival rate of reimplanted fingers in the observation group was 88.00%, which was higher than that in the control group 80.00% (P < 0.05); the satisfaction of doctors, nurses, and patients in the observation group was higher than that in the control group; the concentrations of interleukin-1 (IL-1), tumor necrosis factor (TNF-α), blood flow resistance index (RI), and arterial pulsatility index (PI) in the observation group were lower than those in the control group, while the concentration of interleukin-10 (IL-10), vascular diameter, and Vm (mean blood flow velocity) were higher in the observation group than those in the control group; the differences were statistically significant (P < 0.05). The difference in the incidence of adverse reactions between the two groups was not statistically significant (P > 0.05). The concentrations of PI3K, AKT, and mTOR proteins in the observation group were higher than those in the control group (P < 0.05). The concentrations of PI3K, AKT, and mTOR proteins in the observation group were higher than those in the control group (P < 0.05). Overall, these findings suggest that clustered care combined with papaverine injection reduces vascular inflammatory symptoms and vascular crisis in the treatment of severed finger replantation through the PI3K/AKT/mTOR signaling pathway.
(© 2023. The Author(s).)
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معلومات مُعتمدة: 2022-NWKY-053 Autonomous region health system research subjects
فهرسة مساهمة: Keywords: Clustered nursing care; PI3K/AKT/mTOR signaling pathway; Papaverine injection; Severed finger replantation; Vascular crisis; Vascular inflammation
المشرفين على المادة: EC 2.7.11.1 (TOR Serine-Threonine Kinases)
EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
DAA13NKG2Q (Papaverine)
EC 2.7.1.1 (MTOR protein, human)
EC 2.7.1.- (Phosphatidylinositol 3-Kinases)
تواريخ الأحداث: Date Created: 20230725 Date Completed: 20240704 Latest Revision: 20240729
رمز التحديث: 20240729
مُعرف محوري في PubMed: PMC11224086
DOI: 10.1007/s11010-023-04796-y
PMID: 37490177
قاعدة البيانات: MEDLINE
الوصف
تدمد:1573-4919
DOI:10.1007/s11010-023-04796-y