دورية أكاديمية
أعرض في EDS

A Frame-by-Frame Glance at Membrane Fusion Mechanisms: From Viral Infections to Fertilization.

التفاصيل البيبلوغرافية
العنوان: A Frame-by-Frame Glance at Membrane Fusion Mechanisms: From Viral Infections to Fertilization.
المؤلفون: Azimi FC; Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada., Dean TT; Pharmaceutical Sciences, University of Illinois Chicago, Chicago, IL 60612, USA., Minari K; Biomolecular Cryo-Electron Microscopy Facility, University of California-Santa Cruz, Santa Cruz, CA 95064, USA., Basso LGM; Laboratório de Ciências Físicas, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, Rio de Janeiro 28013-602, Brazil., Vance TDR; Department of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada., Serrão VHB; Biomolecular Cryo-Electron Microscopy Facility, University of California-Santa Cruz, Santa Cruz, CA 95064, USA.; Department of Chemistry and Biochemistry, University of California-Santa Cruz, Santa Cruz, CA 95064, USA.
المصدر: Biomolecules [Biomolecules] 2023 Jul 14; Vol. 13 (7). Date of Electronic Publication: 2023 Jul 14.
نوع المنشور: Journal Article; Review; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101596414 Publication Model: Electronic Cited Medium: Internet ISSN: 2218-273X (Electronic) Linking ISSN: 2218273X NLM ISO Abbreviation: Biomolecules Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, 2011-
مواضيع طبية MeSH: Membrane Fusion* , Virus Diseases*, Humans ; Viral Fusion Proteins/chemistry ; Antiviral Agents ; Fertilization
مستخلص: Viral entry and fertilization are distinct biological processes that share a common mechanism: membrane fusion. In viral entry, enveloped viruses attach to the host cell membrane, triggering a series of conformational changes in the viral fusion proteins. This results in the exposure of a hydrophobic fusion peptide, which inserts into the host membrane and brings the viral and host membranes into close proximity. Subsequent structural rearrangements in opposing membranes lead to their fusion. Similarly, membrane fusion occurs when gametes merge during the fertilization process, though the exact mechanism remains unclear. Structural biology has played a pivotal role in elucidating the molecular mechanisms underlying membrane fusion. High-resolution structures of the viral and fertilization fusion-related proteins have provided valuable insights into the conformational changes that occur during this process. Understanding these mechanisms at a molecular level is essential for the development of antiviral therapeutics and tools to influence fertility. In this review, we will highlight the biological importance of membrane fusion and how protein structures have helped visualize both common elements and subtle divergences in the mechanisms behind fusion; in addition, we will examine the new tools that recent advances in structural biology provide researchers interested in a frame-by-frame understanding of membrane fusion.
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معلومات مُعتمدة: S10 OD025097 United States OD NIH HHS; S10OD02509 United States NH NIH HHS
فهرسة مساهمة: Keywords: cryo-electron microscopy; fertilization; fusion mechanism; membrane fusion; structural biology; viruses
المشرفين على المادة: 0 (Viral Fusion Proteins)
0 (Antiviral Agents)
تواريخ الأحداث: Date Created: 20230729 Date Completed: 20230731 Latest Revision: 20240804
رمز التحديث: 20240804
مُعرف محوري في PubMed: PMC10377500
DOI: 10.3390/biom13071130
PMID: 37509166
قاعدة البيانات: MEDLINE
الوصف
تدمد:2218-273X
DOI:10.3390/biom13071130