دورية أكاديمية
أعرض في EDS

Case Report: The Challenge for Diagnosis of Myocarditis and Transplant Rejection After COVID Infection in a Heart-Transplanted Adolescent.

التفاصيل البيبلوغرافية
العنوان: Case Report: The Challenge for Diagnosis of Myocarditis and Transplant Rejection After COVID Infection in a Heart-Transplanted Adolescent.
المؤلفون: Pegado HM; Heart Institute (InCor), University of São Paulo Medical School (FMUSP), São Paulo, Brasil., Siqueira A; Heart Institute (InCor), University of São Paulo Medical School (FMUSP), São Paulo, Brasil., Navarajasegaran J; Oxford University, Oxford, UK., Benvenuti LA; Heart Institute (InCor), University of São Paulo Medical School (FMUSP), São Paulo, Brasil., Castro CRP; Heart Institute (InCor), University of São Paulo Medical School (FMUSP), São Paulo, Brasil., Arrieta SR; Heart Institute (InCor), University of São Paulo Medical School (FMUSP), São Paulo, Brasil., Gutierrez PS; Heart Institute (InCor), University of São Paulo Medical School (FMUSP), São Paulo, Brasil., Dolhnikoff M; Pathology Department, University of São Paulo Medical School (FMUSP), São Paulo, Brasil., Aiello VD; Heart Institute (InCor), University of São Paulo Medical School (FMUSP), São Paulo, Brasil., Jatene MB; Heart Institute (InCor), University of São Paulo Medical School (FMUSP), São Paulo, Brasil., Azeka E; Heart Institute (InCor), University of São Paulo Medical School (FMUSP), São Paulo, Brasil. Electronic address: estela.azeka@hc.fm.usp.br.
المصدر: Transplantation proceedings [Transplant Proc] 2023 Jul-Aug; Vol. 55 (6), pp. 1449-1450. Date of Electronic Publication: 2023 Jul 27.
نوع المنشور: Case Reports; Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Inc Country of Publication: United States NLM ID: 0243532 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2623 (Electronic) Linking ISSN: 00411345 NLM ISO Abbreviation: Transplant Proc Subsets: MEDLINE
أسماء مطبوعة: Publication: New York, N.Y. : Elsevier Science Inc.
Original Publication: New York Stratton.
مواضيع طبية MeSH: Myocarditis*/diagnosis , Myocarditis*/pathology , COVID-19* , Heart Transplantation*/adverse effects, Humans ; Adolescent ; Female ; Graft Rejection ; SARS-CoV-2 ; Biopsy ; COVID-19 Testing
مستخلص: Patients who have undergone organ transplantation are immunosuppressed hosts, leaving them at a higher risk of infections. SARS-COV-2 has been shown to affect heart-transplanted patients. In this case report, we present the case of a 14-year-old heart transplant recipient who developed signs and symptoms of heart failure, along with fatigue, after a COVID-19 infection. An endomyocardial biopsy was performed to diagnose rejection and to evaluate whether this was myocarditis due to SARS-COV-2. The biopsy showed intense acute cellular rejection (3R) and antibody rejection PAMR1 H+ but was negative for the SARS-CoV-2 virus. The patient received organ rejection therapy with high-dose methylprednisolone and human immunoglobulin. After treatment, her heart function recovered, with biopsy investigations showing a lower level of cellular rejection (1R).
Competing Interests: Declaration of Competing Interest All the authors declare no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
تواريخ الأحداث: Date Created: 20230729 Date Completed: 20231102 Latest Revision: 20231102
رمز التحديث: 20231215
DOI: 10.1016/j.transproceed.2023.06.003
PMID: 37516626
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-2623
DOI:10.1016/j.transproceed.2023.06.003