دورية أكاديمية
Otitis Media in Children with Down Syndrome Is Associated with Shifts in the Nasopharyngeal and Middle Ear Microbiotas.
| العنوان: | Otitis Media in Children with Down Syndrome Is Associated with Shifts in the Nasopharyngeal and Middle Ear Microbiotas. |
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| المؤلفون: | Elling CL; Department of Otolaryngology-Head and Neck Surgery, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.; Human Medical Genetics and Genomics Program, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Goff SH; Department of Pediatric Otolaryngology, Children's Hospital Colorado, Aurora, Colorado, USA., Hirsch SD; Department of Otolaryngology-Head and Neck Surgery, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Tholen K; Department of Pediatric Otolaryngology, Children's Hospital Colorado, Aurora, Colorado, USA., Kofonow JM; Division of Infectious Diseases, Department of Medicine, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Curtis D; Department of Otolaryngology-Head and Neck Surgery, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Robertson CE; Division of Infectious Diseases, Department of Medicine, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Prager JD; Department of Otolaryngology-Head and Neck Surgery, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.; Department of Pediatric Otolaryngology, Children's Hospital Colorado, Aurora, Colorado, USA., Yoon PJ; Department of Otolaryngology-Head and Neck Surgery, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.; Department of Pediatric Otolaryngology, Children's Hospital Colorado, Aurora, Colorado, USA., Wine TM; Department of Otolaryngology-Head and Neck Surgery, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.; Department of Pediatric Otolaryngology, Children's Hospital Colorado, Aurora, Colorado, USA., Chan KH; Department of Otolaryngology-Head and Neck Surgery, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.; Department of Pediatric Otolaryngology, Children's Hospital Colorado, Aurora, Colorado, USA., Scholes MA; Department of Otolaryngology-Head and Neck Surgery, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.; Department of Pediatric Otolaryngology, Children's Hospital Colorado, Aurora, Colorado, USA., Friedman NR; Department of Otolaryngology-Head and Neck Surgery, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.; Department of Pediatric Otolaryngology, Children's Hospital Colorado, Aurora, Colorado, USA., Frank DN; Division of Infectious Diseases, Department of Medicine, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Herrmann BW; Department of Otolaryngology-Head and Neck Surgery, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.; Department of Pediatric Otolaryngology, Children's Hospital Colorado, Aurora, Colorado, USA., Santos-Cortez RLP; Department of Otolaryngology-Head and Neck Surgery, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.; Center for Children's Surgery, Children's Hospital Colorado, Aurora, Colorado, USA. |
| المصدر: | Genetic testing and molecular biomarkers [Genet Test Mol Biomarkers] 2023 Jul; Vol. 27 (7), pp. 221-228. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 101494210 Publication Model: Print Cited Medium: Internet ISSN: 1945-0257 (Electronic) Linking ISSN: 19450257 NLM ISO Abbreviation: Genet Test Mol Biomarkers Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New Rochelle, NY : Mary Ann Liebert, Inc. |
| مواضيع طبية MeSH: | Down Syndrome*/genetics , Otitis Media*/genetics , Microbiota*/genetics, Child ; Humans ; Child, Preschool ; RNA, Ribosomal, 16S/genetics ; Ear, Middle/microbiology ; Ear, Middle/pathology |
| مستخلص: | Background: Otitis media (OM) is defined as middle ear (ME) inflammation that is usually due to infection. Globally, OM is a leading cause of hearing loss and is the most frequently diagnosed disease in young children. For OM, pediatric patients with Down syndrome (DS) demonstrate higher incidence rates, greater severity, and poorer outcomes. However, to date, no studies have investigated the bacterial profiles of children with DS and OM. Method: We aimed to determine if there are differences in composition of bacterial profiles or the relative abundance of individual taxa within the ME and nasopharyngeal (NP) microbiotas of pediatric OM patients with DS ( n = 11) compared with those without DS ( n = 84). We sequenced the 16S rRNA genes and analyzed the sequence data for diversity indices and relative abundance of individual taxa. Results: Individuals with DS demonstrated increased biodiversity in their ME and NP microbiotas. In children with OM, DS was associated with increased biodiversity and higher relative abundance of specific taxa in the ME. Conclusion: Our findings suggest that dysbioses in the NP of DS children contributes to their increased susceptibility to OM compared with controls. These findings suggest that DS influences regulation of the mucosal microbiota and contributes to OM pathology. |
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| معلومات مُعتمدة: | R01 DC015004 United States DC NIDCD NIH HHS; T32 DC012280 United States DC NIDCD NIH HHS |
| فهرسة مساهمة: | Keywords: 16S rRNA gene sequencing; Down syndrome; microbiota; middle ear; nasopharynx; otitis media |
| المشرفين على المادة: | 0 (RNA, Ribosomal, 16S) |
| تواريخ الأحداث: | Date Created: 20230731 Date Completed: 20230807 Latest Revision: 20240702 |
| رمز التحديث: | 20240702 |
| مُعرف محوري في PubMed: | PMC10494904 |
| DOI: | 10.1089/gtmb.2023.0132 |
| PMID: | 37522794 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1945-0257 |
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| DOI: | 10.1089/gtmb.2023.0132 |