دورية أكاديمية
A data-driven Boolean model explains memory subsets and evolution in CD8+ T cell exhaustion.
| العنوان: | A data-driven Boolean model explains memory subsets and evolution in CD8+ T cell exhaustion. |
|---|---|
| المؤلفون: | Ildefonso GV; Alfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, California, USA., Finley SD; Alfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, California, USA. sfinley@usc.edu.; Department of Quantitative and Computational Biology, University of Southern California, Los Angeles, California, USA. sfinley@usc.edu.; Mork Family Department of Chemical Engineering and Materials Science, University of Southern California, Los Angeles, California, USA. sfinley@usc.edu. |
| المصدر: | NPJ systems biology and applications [NPJ Syst Biol Appl] 2023 Jul 31; Vol. 9 (1), pp. 36. Date of Electronic Publication: 2023 Jul 31. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Publishing Group in partnership with SBI, The Systems Biology Institute Country of Publication: England NLM ID: 101677786 Publication Model: Electronic Cited Medium: Internet ISSN: 2056-7189 (Electronic) Linking ISSN: 20567189 NLM ISO Abbreviation: NPJ Syst Biol Appl Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [London] : Nature Publishing Group in partnership with SBI, The Systems Biology Institute, [2015]- |
| مواضيع طبية MeSH: | T-Cell Exhaustion* , Neoplasms*/genetics , Neoplasms*/metabolism, Humans ; CD8-Positive T-Lymphocytes/metabolism ; Cell Differentiation/genetics ; Lymphocyte Activation |
| مستخلص: | T cells play a key role in a variety of immune responses, including infection and cancer. Upon stimulation, naïve CD8+ T cells proliferate and differentiate into a variety of memory and effector cell types; however, failure to clear antigens causes prolonged stimulation of CD8+ T cells, ultimately leading to T cell exhaustion (TCE). The functional and phenotypic changes that occur during CD8+ T cell differentiation are well characterized, but the underlying gene expression state changes are not completely understood. Here, we utilize a previously published data-driven Boolean model of gene regulatory interactions shown to mediate TCE. Our network analysis and modeling reveal the final gene expression states that correspond to TCE, along with the sequence of gene expression patterns that give rise to those final states. With a model that predicts the changes in gene expression that lead to TCE, we could evaluate strategies to inhibit the exhausted state. Overall, we demonstrate that a common pathway model of CD8+ T cell gene regulatory interactions can provide insights into the transcriptional changes underlying the evolution of cell states in TCE. (© 2023. The Author(s).) |
| References: | J Immunol. 2008 Oct 1;181(7):4832-9. (PMID: 18802087) J Immunol. 2008 Dec 15;181(12):8576-84. (PMID: 19050277) Immunity. 2019 Nov 19;51(5):840-855.e5. (PMID: 31606264) Proc Natl Acad Sci U S A. 2018 May 1;115(18):4749-4754. (PMID: 29654146) N Engl J Med. 2012 Jun 28;366(26):2443-54. (PMID: 22658127) Sci Immunol. 2022 Feb 18;7(68):eabi4919. (PMID: 35179948) Sci Rep. 2018 Aug 13;8(1):12077. (PMID: 30104572) Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):E1178-E1187. (PMID: 28137869) Exp Mol Med. 2021 Feb;53(2):202-209. (PMID: 33627794) Mol Ther. 2022 Feb 2;30(2):593-605. (PMID: 34678512) Immunometabolism. 2021;3(1):. (PMID: 33604081) Immunity. 2013 Aug 22;39(2):286-97. (PMID: 23932570) Front Immunol. 2018 Dec 07;9:2826. (PMID: 30581433) Immunity. 2009 Aug 21;31(2):309-20. (PMID: 19664943) Cancer Cell. 2018 Apr 9;33(4):547-562. (PMID: 29634943) Signal Transduct Target Ther. 2021 Dec 13;6(1):412. (PMID: 34897277) Cell Res. 2020 Aug;30(8):649-659. (PMID: 32709897) iScience. 2020 Apr 24;23(4):101023. (PMID: 32325413) Sci Rep. 2020 Feb 5;10(1):1915. (PMID: 32024856) Front Immunol. 2020 May 22;11:1013. (PMID: 32670270) J Exp Med. 2015 Jun 29;212(7):1125-37. (PMID: 26034050) FASEB J. 2021 May;35(5):e21549. (PMID: 33913198) Front Immunol. 2021 Jul 20;12:715234. (PMID: 34354714) J Exp Med. 2013 Jun 3;210(6):1189-200. (PMID: 23712431) PLoS Comput Biol. 2007 Aug;3(8):e163. (PMID: 17722974) Cancer Res. 2018 Jul 1;78(13):3619-3633. (PMID: 29691251) Blood. 2006 Dec 1;108(12):3818-23. (PMID: 16882704) J Immunol. 2007 Jun 15;178(12):7640-8. (PMID: 17548600) Nat Immunol. 2014 Apr;15(4):373-83. (PMID: 24584090) Nat Rev Immunol. 2012 Nov;12(11):749-61. (PMID: 23080391) Trends Immunol. 2020 Jan;41(1):17-28. (PMID: 31810790) Proc Natl Acad Sci U S A. 2019 May 14;116(20):9959-9968. (PMID: 31019078) Cell Rep. 2020 Jun 30;31(13):107827. (PMID: 32610128) Front Immunol. 2018 Nov 20;9:2692. (PMID: 30515169) Front Immunol. 2017 Dec 04;8:1597. (PMID: 29255458) Blood. 2018 Jan 4;131(1):58-67. (PMID: 29118008) Front Pharmacol. 2017 Aug 23;8:561. (PMID: 28878676) Immunity. 2001 Jan;14(1):13-20. (PMID: 11163226) PLoS Comput Biol. 2019 Mar 7;15(3):e1006855. (PMID: 30845219) Sci Immunol. 2020 Nov 6;5(53):. (PMID: 33158974) Front Endocrinol (Lausanne). 2021 Feb 01;11:624122. (PMID: 33597928) Front Immunol. 2018 Dec 20;9:2987. (PMID: 30619342) Nat Immunol. 2021 Aug;22(8):983-995. (PMID: 34282330) Curr Opin Immunol. 1993 Jun;5(3):334-40. (PMID: 8347296) Immunol Rev. 2022 Jan;305(1):77-89. (PMID: 34923638) Trends Immunol. 2016 Aug;37(8):557-568. (PMID: 27389961) Nat Rev Immunol. 2016 Feb;16(2):102-11. (PMID: 26781939) J Immunol. 2019 Jul 15;203(2):323-327. (PMID: 31175159) Nature. 2019 Mar;567(7749):525-529. (PMID: 30814730) Cancers (Basel). 2019 Jul 23;11(7):. (PMID: 31340499) Nat Rev Immunol. 2021 Nov;21(11):718-738. (PMID: 33981085) Nat Rev Immunol. 2018 May;18(5):340-356. (PMID: 29379213) Genes Dev. 2012 May 1;26(9):877-90. (PMID: 22549953) Nat Immunol. 2021 Mar;22(3):358-369. (PMID: 33432230) Front Immunol. 2018 Jan 30;9:101. (PMID: 29441071) J R Soc Interface. 2008 Aug 6;5 Suppl 1:S85-94. (PMID: 18508746) Comput Struct Biotechnol J. 2020 Mar 10;18:571-582. (PMID: 32257043) Front Immunol. 2018 Dec 21;9:2736. (PMID: 30619240) Immunity. 2014 Nov 20;41(5):802-14. (PMID: 25464856) Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4565-70. (PMID: 17360564) Nat Rev Immunol. 2022 Apr;22(4):209-223. (PMID: 34253904) Nat Immunol. 2014 Dec;15(12):1143-51. (PMID: 25344724) Sci Immunol. 2016 Dec 23;1(6):. (PMID: 28018990) J Hematol Oncol. 2018 Jan 12;11(1):8. (PMID: 29329556) Eur J Immunol. 2014 Jul;44(7):1886-95. (PMID: 24782159) Front Physiol. 2020 Apr 23;11:380. (PMID: 32425809) Nat Immunol. 2002 Jun;3(6):558-63. (PMID: 12021781) Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1549-54. (PMID: 21205892) Front Immunol. 2013 Feb 01;4:20. (PMID: 23378844) Immunology. 2023 Jan;168(1):30-48. (PMID: 36190809) J Immunol. 2008 Dec 1;181(11):7617-29. (PMID: 19017950) |
| تواريخ الأحداث: | Date Created: 20230731 Date Completed: 20230802 Latest Revision: 20230803 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC10390540 |
| DOI: | 10.1038/s41540-023-00297-2 |
| PMID: | 37524735 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 2056-7189 |
|---|---|
| DOI: | 10.1038/s41540-023-00297-2 |