دورية أكاديمية
أعرض في EDS

Toward the use of MRI measurements of bound and pore water in fracture risk assessment.

التفاصيل البيبلوغرافية
العنوان: Toward the use of MRI measurements of bound and pore water in fracture risk assessment.
المؤلفون: Nyman JS; Department of Orthopaedic Surgery, Vanderbilt University Medical Center, 1215 21st Ave. S., Suite 4200, Nashville, TN 37232, USA; Department of Biomedical Engineering, Vanderbilt University, 5824 Stevenson Center, Nashville, TN 37232, USA; Department of Veterans Affairs, Tennessee Valley Healthcare System, 1310 24th Ave. S., Nashville, TN 37212, USA; Vanderbilt Center for Bone Biology, Vanderbilt University Medical Center,1211 Medical Center Dr., Nashville, TN 37212, USA. Electronic address: jeffry.s.nyman@vumc.org., Ketsiri T; Department of Biomedical Engineering, Vanderbilt University, 5824 Stevenson Center, Nashville, TN 37232, USA; Institute of Imaging Science, Vanderbilt University Medical Center, 1161 21st Ave. S., Nashville, TN 37232, USA., Louie EA; Institute of Imaging Science, Vanderbilt University Medical Center, 1161 21st Ave. S., Nashville, TN 37232, USA., Harkins KD; Department of Biomedical Engineering, Vanderbilt University, 5824 Stevenson Center, Nashville, TN 37232, USA; Institute of Imaging Science, Vanderbilt University Medical Center, 1161 21st Ave. S., Nashville, TN 37232, USA; Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, 1161 21st Ave. S., Nashville, TN 37232, USA., Manhard MK; Imaging Research Center, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA., Gochberg DF; Institute of Imaging Science, Vanderbilt University Medical Center, 1161 21st Ave. S., Nashville, TN 37232, USA; Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, 1161 21st Ave. S., Nashville, TN 37232, USA., Lee DH; Department of Orthopaedic Surgery, Vanderbilt University Medical Center, 1215 21st Ave. S., Suite 4200, Nashville, TN 37232, USA., Desai MJ; Department of Orthopaedic Surgery, Vanderbilt University Medical Center, 1215 21st Ave. S., Suite 4200, Nashville, TN 37232, USA., Maslow J; Department of Orthopaedic Surgery, Vanderbilt University Medical Center, 1215 21st Ave. S., Suite 4200, Nashville, TN 37232, USA., Tanner SB; Vanderbilt Center for Bone Biology, Vanderbilt University Medical Center,1211 Medical Center Dr., Nashville, TN 37212, USA; Department of Medicine, Division of Rheumatology, Vanderbilt University Medical Center, 1161 21st Ave. S., Nashville, TN 37232, USA., Does MD; Department of Biomedical Engineering, Vanderbilt University, 5824 Stevenson Center, Nashville, TN 37232, USA; Institute of Imaging Science, Vanderbilt University Medical Center, 1161 21st Ave. S., Nashville, TN 37232, USA; Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, 1161 21st Ave. S., Nashville, TN 37232, USA; Department of Electrical Engineering and Computer Science, Vanderbilt University, 400 24th Ave. S., Nashville, TN 37212, USA. Electronic address: mark.does@vanderbilt.edu.
المصدر: Bone [Bone] 2023 Nov; Vol. 176, pp. 116863. Date of Electronic Publication: 2023 Jul 30.
نوع المنشور: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8504048 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2763 (Electronic) Linking ISSN: 18732763 NLM ISO Abbreviation: Bone Subsets: MEDLINE
أسماء مطبوعة: Publication: New York : Elsevier Science
Original Publication: Elmsford, NY : Pergamon Press, c1985-
مواضيع طبية MeSH: Fractures, Bone*/diagnostic imaging , Osteoporosis*/diagnostic imaging, Adult ; Humans ; Female ; Water ; Bayes Theorem ; Magnetic Resonance Imaging/methods ; Risk Assessment ; Bone Density
مستخلص: The current clinical assessment of fracture risk lacks information about the inherent quality of a person's bone tissue. Working toward an imaging-based approach to quantify both a bone tissue quality marker (tissue hydration as water bound to the matrix) and a bone microstructure marker (porosity as water in pores), we hypothesized that the concentrations of bound water (C bw ) are lower and concentrations of pore water (C pw ) are higher in patients with osteoporosis (OP) than in age- and sex-matched adults without the disease. Using recent developments in ultrashort echo time (UTE) magnetic resonance imaging (MRI), maps of C bw and C pw were acquired from the uninjured distal third radius (Study 1) of 20 patients who experienced a fragility fracture of the distal radius (Fx) and 20 healthy controls (Non-Fx) and from the tibia mid-diaphysis (Study 2) of 30 women with clinical OP (low T-scores) and 15 women without OP (normal T-scores). In Study 1, C bw was significantly lower (p = 0.0018) and C pw was higher (p = 0.0022) in the Fx than in the Non-Fx group. In forward stepwise, logistic regression models using Bayesian Information Criterion for selecting the best set of predictors (from imaging parameters, age, BMI, and DXA scanner type), the area-under-the-receiver operator characteristics-curve (AUC with 95 % confidence intervals) was 0.73 (0.56, 0.86) for hip aBMD (best predictors without MRI) and 0.86 (0.70, 0.95) for the combination of C bw and C pw (best predictors overall). In Study 2, C bw was significantly lower (p = 0.0005) in women with OP (23.8 ± 4.3 1 H mol/L) than in women without OP (29.9 ± 6.4 1 H mol/L); C pw was significantly higher by estimate of 2.9 1 H mol/L (p = 0.0298) with clinical OP, but only when accounting for the type of UTE-MRI scan with 3D providing higher values than 2D (p < 0.0001). Lastly, C bw , but not C pw , was sensitive to bone forming osteoporosis medications over 12-months. UTE-MRI-derived measurements of bound and pore water concentrations are potential, aBMD-independent predictors of fracture risk.
Competing Interests: Declaration of competing interest There are no conflicts of interest to disclose.
(Published by Elsevier Inc.)
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معلومات مُعتمدة: I01 BX004297 United States BX BLRD VA; R01 EB014308 United States EB NIBIB NIH HHS; UL1 TR002243 United States TR NCATS NIH HHS
فهرسة مساهمة: Keywords: Bound water; Fracture; MRI; Osteoporosis; Pore water; UTE
المشرفين على المادة: 059QF0KO0R (Water)
تواريخ الأحداث: Date Created: 20230801 Date Completed: 20230919 Latest Revision: 20231003
رمز التحديث: 20231003
مُعرف محوري في PubMed: PMC10528882
DOI: 10.1016/j.bone.2023.116863
PMID: 37527697
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-2763
DOI:10.1016/j.bone.2023.116863