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Microbial short-chain fatty acids regulate drug seeking and transcriptional control in a model of cocaine seeking.

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العنوان: Microbial short-chain fatty acids regulate drug seeking and transcriptional control in a model of cocaine seeking.
المؤلفون: Meckel KR; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Biology, Swarthmore College, Swarthmore, PA, 19081, USA., Simpson SS; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Godino A; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Peck EG; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Physiology & Pharmacology, Wake Forest University School of Medicine, Atrium Wake Forest Baptist Health, Winston-Salem, NC, 27101, USA., Sens JP; Department of Physiology & Pharmacology, Wake Forest University School of Medicine, Atrium Wake Forest Baptist Health, Winston-Salem, NC, 27101, USA., Leonard MZ; Department of Pharmacology, Vanderbilt University, Nashville, TN, USA., George O; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Calipari ES; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Pharmacology, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Brain Institute, Vanderbilt University, 865F Light Hall, 2215 Garland Avenue, Nashville, TN, 37232, USA.; Vanderbilt Center for Addiction Research, Vanderbilt University, Nashville, TN, USA.; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA.; Department of Psychiatry and Behavioral Sciences, Vanderbilt University, Nashville, TN, USA., Hofford RS; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Physiology & Pharmacology, Wake Forest University School of Medicine, Atrium Wake Forest Baptist Health, Winston-Salem, NC, 27101, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Kiraly DD; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. dkiraly@wakehealth.edu.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. dkiraly@wakehealth.edu.; Department of Physiology & Pharmacology, Wake Forest University School of Medicine, Atrium Wake Forest Baptist Health, Winston-Salem, NC, 27101, USA. dkiraly@wakehealth.edu.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. dkiraly@wakehealth.edu.; Department of Psychiatry, Wake Forest University School of Medicine, Atrium Wake Forest Baptist Health, Winston-Salem, NC, 27101, USA. dkiraly@wakehealth.edu.
المصدر: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology [Neuropsychopharmacology] 2024 Jan; Vol. 49 (2), pp. 386-395. Date of Electronic Publication: 2023 Aug 02.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8904907 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1740-634X (Electronic) Linking ISSN: 0893133X NLM ISO Abbreviation: Neuropsychopharmacology Subsets: MEDLINE
أسماء مطبوعة: Publication: 2003- : London : Nature Publishing Group
Original Publication: [New York, NY] : Elsevier, [c1987-
مواضيع طبية MeSH: Cocaine* , Cocaine-Related Disorders*/metabolism, Mice ; Rats ; Male ; Animals ; Rats, Sprague-Dawley ; Drug-Seeking Behavior ; Nucleus Accumbens ; Recurrence ; Self Administration ; Cues ; Extinction, Psychological
مستخلص: Cocaine use disorder represents a public health crisis with no FDA-approved medications for its treatment. A growing body of research has detailed the important connections between the brain and the resident population of bacteria in the gut, the gut microbiome, in psychiatric disease models. Acute depletion of gut bacteria results in enhanced reward in a mouse cocaine place preference model, and repletion of bacterially-derived short-chain fatty acid (SCFA) metabolites reverses this effect. However, the role of the gut microbiome and its metabolites in modulating cocaine-seeking behavior after prolonged abstinence is unknown. Given that relapse prevention is the most clinically challenging issue in treating substance use disorders, studies examining the effects of microbiome manipulations in relapse-relevant models are critical. Here, male Sprague-Dawley rats received either untreated water or antibiotics to deplete the gut microbiome and its metabolites. Rats were trained to self-administer cocaine and subjected to either within-session threshold testing to evaluate motivation for cocaine or 21 days of abstinence followed by a cue-induced cocaine-seeking task to model relapse behavior. Microbiome depletion did not affect cocaine acquisition on an fixed-ratio 1 schedule. However, microbiome-depleted rats exhibited significantly enhanced motivation for low dose cocaine on a within-session threshold task. Similarly, microbiome depletion increased cue-induced cocaine-seeking following prolonged abstinence and altered transcriptional regulation in the nucleus accumbens. In the absence of a normal microbiome, repletion of bacterially-derived SCFA metabolites reversed the behavioral and transcriptional changes associated with microbiome depletion. These findings suggest that gut bacteria, via their metabolites, are key regulators of drug-seeking behaviors, positioning the microbiome as a potential translational research target.
(© 2023. The Author(s), under exclusive licence to American College of Neuropsychopharmacology.)
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معلومات مُعتمدة: K01 DA050906 United States DA NIDA NIH HHS; T32 MH065215 United States MH NIMH NIH HHS; F99 NS124187 United States NS NINDS NIH HHS; DP1 DA051551 United States DA NIDA NIH HHS; R01 DA056592 United States DA NIDA NIH HHS
المشرفين على المادة: I5Y540LHVR (Cocaine)
تواريخ الأحداث: Date Created: 20230801 Date Completed: 20231218 Latest Revision: 20240501
رمز التحديث: 20240501
مُعرف محوري في PubMed: PMC10724273
DOI: 10.1038/s41386-023-01661-w
PMID: 37528220
قاعدة البيانات: MEDLINE
الوصف
تدمد:1740-634X
DOI:10.1038/s41386-023-01661-w