دورية أكاديمية
أعرض في EDS

Depressive symptoms are associated with fatigue, poorer functional status and less engagement in sports in axSpA and PsA: an analysis from the RABBIT-SpA cohort.

التفاصيل البيبلوغرافية
العنوان: Depressive symptoms are associated with fatigue, poorer functional status and less engagement in sports in axSpA and PsA: an analysis from the RABBIT-SpA cohort.
المؤلفون: Reich A; German Rheumatism Research Center (DRFZ Berlin), Epidemiology and Health Services Research, Berlin, Germany. andreas.reich@drfz.de., Weiß A; German Rheumatism Research Center (DRFZ Berlin), Epidemiology and Health Services Research, Berlin, Germany., Lindner L; German Rheumatism Research Center (DRFZ Berlin), Epidemiology and Health Services Research, Berlin, Germany., Baraliakos X; Ruhr University Bochum, Bochum, Germany.; Rheumazentrum Ruhrgebiet, Herne, Germany., Poddubnyy D; German Rheumatism Research Center (DRFZ Berlin), Epidemiology and Health Services Research, Berlin, Germany.; Charité - Universitätsmedizin Berlin, Department of Gastroenterology, Infectiology and Rheumatology, Berlin, Germany., Zinke S; Berlin, Germany., Stille C; Hannover, Germany., Strangfeld A; German Rheumatism Research Center (DRFZ Berlin), Epidemiology and Health Services Research, Berlin, Germany.; Charité - Universitätsmedizin Berlin, Berlin, Germany., Regierer AC; German Rheumatism Research Center (DRFZ Berlin), Epidemiology and Health Services Research, Berlin, Germany.
المصدر: Arthritis research & therapy [Arthritis Res Ther] 2023 Aug 02; Vol. 25 (1), pp. 136. Date of Electronic Publication: 2023 Aug 02.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101154438 Publication Model: Electronic Cited Medium: Internet ISSN: 1478-6362 (Electronic) Linking ISSN: 14786354 NLM ISO Abbreviation: Arthritis Res Ther Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, 2003-
مواضيع طبية MeSH: Arthritis, Psoriatic*/drug therapy , Spondylarthritis*/drug therapy , Axial Spondyloarthritis*, Humans ; Depression/epidemiology ; Cohort Studies ; Functional Status ; Fatigue/epidemiology ; Fatigue/complications
مستخلص: Background: In patients with axial spondyloarthritis (axSpA) or psoriatic arthritis (PsA), concomitant depression might have a negative impact on the course of disease and treatment outcomes. The aims of this analysis are to determine the prevalence of depressive symptoms in axSpA and PsA patients in a real-world cohort study and to identify sociodemographic and clinical associated factors for moderate or severe depressive symptoms in both diseases.
Methods: Patients from the RABBIT-SpA cohort with an axSpA or PsA diagnosis and a valid WHO-5 Well-Being Index score at baseline were included. A descriptive analysis of baseline and outcome parameters by category of depressive symptoms was performed and factors associated with the presence of depressive symptoms (moderate or severe) were examined in a logistic regression.
Results: Two thousand four hundred seventy patients (1,245 axSpA; 1,225 PsA) were included in the analysis. In both diagnoses, the proportion of patients with moderate depressive symptoms was 8% and 21% with severe symptoms. Patients with moderate or severe depressive symptoms were less likely to engage in sports than those with no or mild depressive symptoms, had more comorbidities and higher scores for disease activity, functional limitations, fatigue, and pain and took more analgesics. In axSpA, patients with a higher disease activity, a greater functional impairment and more severe fatigue were more likely to experience depressive symptoms, while patients with more years in education and engaging in sports for at least 1 h/week were less likely to experience depressive symptoms. PsA patients with a greater functional impairment and more severe fatigue were more likely to experience depressive symptoms while those engaging in sports for at least 1 h/week were less likely to experience depressive symptoms.
Conclusion: We confirmed a high prevalence of depressive symptoms in both PsA and axSpA. Factors negatively associated with the presence of depressive symptoms were fatigue, not engaging in sports, and greater functional limitations. Depressive symptoms may affect the perception of disease activity / severity by patients. Thus, depressive symptoms are an important condition in axSpA and PsA that should be considered when evaluating disease activity and treatment outcomes.
(© 2023. The Author(s).)
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فهرسة مساهمة: Keywords: Depression; Observational study; Psoriatic arthritis; Spondyloarthritis
تواريخ الأحداث: Date Created: 20230802 Date Completed: 20230804 Latest Revision: 20230811
رمز التحديث: 20230811
مُعرف محوري في PubMed: PMC10394807
DOI: 10.1186/s13075-023-03127-2
PMID: 37533077
قاعدة البيانات: MEDLINE
الوصف
تدمد:1478-6362
DOI:10.1186/s13075-023-03127-2