دورية أكاديمية
Antileishmanial activity of 2-amino-thiophene derivative SB-200.
العنوان: | Antileishmanial activity of 2-amino-thiophene derivative SB-200. |
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المؤلفون: | Sousa JPA; Infectious Disease Laboratory, Campus Ministro Reis Velloso, Federal University of Parnaíba Delta, 64202-020 Parnaíba, PI, Brasil., Sousa JMS; Infectious Disease Laboratory, Campus Ministro Reis Velloso, Federal University of Parnaíba Delta, 64202-020 Parnaíba, PI, Brasil., Rodrigues RRL; Infectious Disease Laboratory, Campus Ministro Reis Velloso, Federal University of Parnaíba Delta, 64202-020 Parnaíba, PI, Brasil., Nunes TAL; Infectious Disease Laboratory, Campus Ministro Reis Velloso, Federal University of Parnaíba Delta, 64202-020 Parnaíba, PI, Brasil., Machado YAA; Infectious Disease Laboratory, Campus Ministro Reis Velloso, Federal University of Parnaíba Delta, 64202-020 Parnaíba, PI, Brasil., Araujo AC; Infectious Disease Laboratory, Campus Ministro Reis Velloso, Federal University of Parnaíba Delta, 64202-020 Parnaíba, PI, Brasil., da Silva IGM; Microscopy and Microanalysis Laboratory, Department of Cell Biology, Institute of Biological Sciences, University of Brasília, Brasília, Brazil., Barros-Cordeiro KB; Microscopy and Microanalysis Laboratory, Department of Cell Biology, Institute of Biological Sciences, University of Brasília, Brasília, Brazil., Báo SN; Microscopy and Microanalysis Laboratory, Department of Cell Biology, Institute of Biological Sciences, University of Brasília, Brasília, Brazil., Alves MMM; Laboratory of Antileishmania Activity, Medicinal Plants Research Center, Federal University of Piauí, Teresina 64049-550, Brazil., Mendonça-Junior FJB; Molecular Synthesis and Vectorization Laboratory, Department of Biological Sciences, State University of Paraíba, 58071-160 João Pessoa, PB, Brazil., Rodrigues KADF; Infectious Disease Laboratory, Campus Ministro Reis Velloso, Federal University of Parnaíba Delta, 64202-020 Parnaíba, PI, Brasil. Electronic address: klinger@ufpi.edu.br. |
المصدر: | International immunopharmacology [Int Immunopharmacol] 2023 Oct; Vol. 123, pp. 110750. Date of Electronic Publication: 2023 Aug 01. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Amsterdam ; New York : Elsevier Science, c2001- |
مواضيع طبية MeSH: | Antiprotozoal Agents*/pharmacology , Antiprotozoal Agents*/therapeutic use , Leishmaniasis*/drug therapy , Leishmania infantum*, Animals ; Chlorocebus aethiops ; Mice ; Vero Cells ; Thiophenes/pharmacology ; Thiophenes/therapeutic use ; Mice, Inbred BALB C |
مستخلص: | Leishmaniasis, presenting the highest number of cases worldwide is one of the most serious Neglected Tropical Diseases (NTDs). Clinical manifestations are intrinsically related to the host's immune response making immunomodulatory substances the target of numerous studies on antileishmanial activity. The currently available drugs used for treatment present various problems including high toxicity, low efficacy, and associated drug resistance. The search for therapeutic alternatives is urgent, and in this context, thiophene derivatives appear to be a promising therapeutic alternative (many have shown promising anti-leishmanial activity). The objective of this study was to investigate the antileishmanial activity of the 2-amino-thiophenic derivative SB-200. The thiophenic derivative was effective in inhibiting the growth of Leishmania braziliensis, Leishmania major, and Leishmania infantum promastigotes, obtaining respective IC Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2023 Elsevier B.V. All rights reserved.) |
فهرسة مساهمة: | Keywords: 2-Amino-thiophene derivative; Immunomodulation; Leishmaniasis; Visceral leishmaniasis |
المشرفين على المادة: | 0 (Thiophenes) 0 (Antiprotozoal Agents) |
تواريخ الأحداث: | Date Created: 20230803 Date Completed: 20230922 Latest Revision: 20230922 |
رمز التحديث: | 20240628 |
DOI: | 10.1016/j.intimp.2023.110750 |
PMID: | 37536181 |
قاعدة البيانات: | MEDLINE |
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