دورية أكاديمية
أعرض في EDS

Early-life atomic-bomb irradiation accelerates immunological aging and elevates immune-related intracellular reactive oxygen species.

التفاصيل البيبلوغرافية
العنوان: Early-life atomic-bomb irradiation accelerates immunological aging and elevates immune-related intracellular reactive oxygen species.
المؤلفون: Hayashi T; Department of Molecular Biosciences, Radiation Effects Research Foundation, Hiroshima, Japan.; Biosample Research Center, Radiation Effects Research Foundation, Hiroshima, Japan., Kato N; Department of Statistics, Radiation Effects Research Foundation, Hiroshima, Japan., Furudoi K; Biosample Research Center, Radiation Effects Research Foundation, Hiroshima, Japan., Hayashi I; Central Research Laboratory, Hiroshima University Faculty of Medicine Graduate School of Biomedical and Health Sciences, Hiroshima, Japan., Kyoizumi S; Department of Molecular Biosciences, Radiation Effects Research Foundation, Hiroshima, Japan., Yoshida K; Department of Molecular Biosciences, Radiation Effects Research Foundation, Hiroshima, Japan., Kusunoki Y; Department of Molecular Biosciences, Radiation Effects Research Foundation, Hiroshima, Japan., Furukawa K; Biostatistics Center, Kurume University, Kurume, Japan., Imaizumi M; Biosample Research Center, Radiation Effects Research Foundation, Hiroshima, Japan.; Department of Nagasaki Clinical Studies, Radiation Effects Research Foundation, Nagasaki, Japan., Hida A; Department of Nagasaki Clinical Studies, Radiation Effects Research Foundation, Nagasaki, Japan., Tanabe O; Biosample Research Center, Radiation Effects Research Foundation, Hiroshima, Japan., Ohishi W; Department of Hiroshima Clinical Studies, Radiation Effects Research Foundation, Hiroshima, Japan.
المصدر: Aging cell [Aging Cell] 2023 Oct; Vol. 22 (10), pp. e13940. Date of Electronic Publication: 2023 Aug 04.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101130839 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-9726 (Electronic) Linking ISSN: 14749718 NLM ISO Abbreviation: Aging Cell Subsets: MEDLINE
أسماء مطبوعة: Publication: Oxford, UK : Wiley-Blackwell
Original Publication: Oxford, UK : Blackwell Pub., c2002-
مواضيع طبية MeSH: CD8-Positive T-Lymphocytes* , Nuclear Warfare*, Humans ; Reactive Oxygen Species ; Survivors ; Aging ; T-Lymphocyte Subsets ; Immunologic Memory ; CD4-Positive T-Lymphocytes
مستخلص: Reactive oxygen species (ROS) play an important role in immune responses; however, their excessive production and accumulation increases the risk of inflammation-related diseases. Although irradiation is known to accelerate immunological aging, the underlying mechanism is still unclear. To determine the possible involvement of ROS in this mechanism, we examined 10,023 samples obtained from 3752 atomic-bomb survivors in Hiroshima and Nagasaki, who participated in repeated biennial examinations from 2008 to 2016, for the effects of aging and radiation exposure on intracellular ROS (H 2 O 2 and O 2 •- ) levels, percentages of T-cell subsets, and the effects of radiation exposure on the relationship between cell percentages and intracellular ROS levels in T-cell subsets. The cell percentages and intracellular ROS levels in T-cell subsets were measured using flow cytometry, with both fluorescently labeled antibodies and the fluorescent reagents, carboxy-DCFDA and hydroethidine. The percentages of naïve CD4 + and CD8 + T cells decreased with increasing age and radiation dose, while the intracellular O 2 •- levels in central and effector memory CD8 + T cells increased. Additionally, when divided into three groups based on the percentages of naïve CD4 + T cells, intracellular O 2 •- levels of central and effector memory CD8 + T cells were significantly elevated with the lowest radiation dose group in the naïve CD4 + T cells. Thus, the radiation exposure-induced decrease in the naïve CD4 + T cell pool size may reflect decreased immune function, resulting in increased intracellular ROS levels in central and effector memory CD8 + T cells, and increased intracellular oxidative stress.
(© 2023 The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd.)
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فهرسة مساهمة: Keywords: T cell; atomic bomb; central memory; effector memory; immunological aging; naïve; radiation; reactive oxygen species
المشرفين على المادة: 0 (Reactive Oxygen Species)
تواريخ الأحداث: Date Created: 20230804 Date Completed: 20231023 Latest Revision: 20231025
رمز التحديث: 20231026
مُعرف محوري في PubMed: PMC10577552
DOI: 10.1111/acel.13940
PMID: 37539495
قاعدة البيانات: MEDLINE
الوصف
تدمد:1474-9726
DOI:10.1111/acel.13940