دورية أكاديمية
أعرض في EDS

Association Between Incident Type 2 Diabetes and Opium Use: Mediation by Body Mass and Adiposity.

التفاصيل البيبلوغرافية
العنوان: Association Between Incident Type 2 Diabetes and Opium Use: Mediation by Body Mass and Adiposity.
المؤلفون: Nalini M, Poustchi H, Roshandel G, Kamangar F, Khoshnia M, Gharavi A, Brennan P, Boffetta P, Dawsey SM, Abnet CC, Malekzadeh R, Etemadi A
المصدر: American journal of epidemiology [Am J Epidemiol] 2023 Nov 10; Vol. 192 (12), pp. 2050-2062.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Oxford University Press Country of Publication: United States NLM ID: 7910653 Publication Model: Print Cited Medium: Internet ISSN: 1476-6256 (Electronic) Linking ISSN: 00029262 NLM ISO Abbreviation: Am J Epidemiol Subsets: MEDLINE
أسماء مطبوعة: Publication: Cary, NC : Oxford University Press
Original Publication: Baltimore, School of Hygiene and Public Health of Johns Hopkins Univ.
مواضيع طبية MeSH: Diabetes Mellitus, Type 2*/epidemiology , Diabetes Mellitus, Type 2*/etiology , Opium Dependence*/epidemiology , Opium Dependence*/complications, Humans ; Female ; Middle Aged ; Male ; Adiposity ; Prospective Studies ; Cohort Studies ; Risk Factors ; Opium/adverse effects ; Obesity/epidemiology ; Obesity/complications ; Body Mass Index ; Waist Circumference ; Incidence
مستخلص: Opiates can affect glucose metabolism and obesity, but no large prospective study (to our knowledge) has investigated the association between long-term opium use, body mass index (BMI; weight (kg)/height (m)2), and incident type 2 diabetes mellitus (T2DM). We analyzed prospective data from 50,045 Golestan Cohort Study participants in Iran (enrollment: 2004-2008). After excluding participants with preexisting diseases, including diabetes, we used adjusted Poisson regression models to estimate incidence rate ratios (IRRs) and 95% confidence intervals (CIs) for T2DM in opium users compared with nonusers, using mediation analysis to assess the BMI-mediated association of opium use with incident T2DM. Of 40,083 included participants (mean age = 51.4 (standard deviation, 8.8) years; 56% female), 16% were opium users (median duration of use, 10 (interquartile range), 4-20) years). During follow-up (until January 2020), 5,342 incident T2DM cases were recorded, including 8.5% of opium users and 14.2% of nonusers. Opium use was associated with an overall decrease in incident T2DM (IRR = 0.83, 95% CI: 0.75, 0.92), with a significant dose-response association. Most (84.3%) of this association was mediated by low BMI or waist circumference, and opium use did not have a direct association with incident T2DM (IRR = 0.97, 95% CI: 0.87, 1.08). Long-term opium use was associated with lower incidence of T2DM, which was mediated by low body mass and adiposity.
(Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health 2023.)
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معلومات مُعتمدة: UL1 GM118973 United States GM NIGMS NIH HHS; C20/A5860 United Kingdom CRUK_ Cancer Research UK
فهرسة مساهمة: Keywords: body mass index; diabetes mellitus, type 2; incidence; obesity; opium; prevention
المشرفين على المادة: 8008-60-4 (Opium)
تواريخ الأحداث: Date Created: 20230808 Date Completed: 20231204 Latest Revision: 20240809
رمز التحديث: 20240809
مُعرف محوري في PubMed: PMC10691200
DOI: 10.1093/aje/kwad166
PMID: 37552966
قاعدة البيانات: MEDLINE
الوصف
تدمد:1476-6256
DOI:10.1093/aje/kwad166