دورية أكاديمية
CMV hyperimmune globulin as salvage therapy for recurrent or refractory CMV infection in children undergoing hematopoietic stem cell transplantation.
| العنوان: | CMV hyperimmune globulin as salvage therapy for recurrent or refractory CMV infection in children undergoing hematopoietic stem cell transplantation. |
|---|---|
| المؤلفون: | Panesso M; Division of Pediatric Oncology and Haematology, Hospital Universitari Vall d'Hebron, Barcelona, Spain.; Institut de Recerca Vall d'Hebron, Barcelona, Spain., Uría ML; Division of Pediatric Oncology and Haematology, Hospital Universitari Vall d'Hebron, Barcelona, Spain.; Institut de Recerca Vall d'Hebron, Barcelona, Spain., Renedo B; Institut de Recerca Vall d'Hebron, Barcelona, Spain.; Pharmacy Division, Hospital Universitari Vall d'Hebron, Barcelona, Spain., Esperalba J; Institut de Recerca Vall d'Hebron, Barcelona, Spain.; Microbiology Division, Hospital Universitari Vall d'Hebron, Barcelona, Spain., Benítez-Carabante MI; Division of Pediatric Oncology and Haematology, Hospital Universitari Vall d'Hebron, Barcelona, Spain.; Institut de Recerca Vall d'Hebron, Barcelona, Spain., Mendoza-Palomar N; Institut de Recerca Vall d'Hebron, Barcelona, Spain.; Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain., Alonso L; Division of Pediatric Oncology and Haematology, Hospital Universitari Vall d'Hebron, Barcelona, Spain.; Institut de Recerca Vall d'Hebron, Barcelona, Spain., Oliveras M; Institut de Recerca Vall d'Hebron, Barcelona, Spain.; Pharmacy Division, Hospital Universitari Vall d'Hebron, Barcelona, Spain., Diaz-de-Heredia C; Division of Pediatric Oncology and Haematology, Hospital Universitari Vall d'Hebron, Barcelona, Spain.; Institut de Recerca Vall d'Hebron, Barcelona, Spain. |
| المصدر: | Frontiers in pediatrics [Front Pediatr] 2023 Jul 24; Vol. 11, pp. 1197828. Date of Electronic Publication: 2023 Jul 24 (Print Publication: 2023). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Media SA Country of Publication: Switzerland NLM ID: 101615492 Publication Model: eCollection Cited Medium: Print ISSN: 2296-2360 (Print) Linking ISSN: 22962360 NLM ISO Abbreviation: Front Pediatr Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Lausanne : Frontiers Media SA, [2013]- |
| مستخلص: | Cytomegalovirus (CMV) is a major cause of allogeneic hematopoietic stem cell transplant (HSCT)-related morbidity and mortality. Treatment failure continues to be a major issue in patients with CMV infection due to both drug resistance and intolerance. This single-center brief retrospective analysis of a case series aims to investigate the safety and efficacy of CMV-hyperimmune globulin as salvage therapy for CMV infection in children undergoing HSCT. Fifteen pediatric patients received human CMV-specific immunoglobulin (CMVIG) between July 2018 and December 2021 as a salvage therapy for refractory or recurrent CMV infection. At the time of CMVIG prescription, eight children presented with recurrent CMV infection and seven with refractory CMV infection. The overall response rate was 67% at 50 days from the CMVIG administration [95% confidence interval (CI): 44-88]. Overall survival (OS) from CMVIG administration at 100 days was 87% (95% CI: 56-96), and OS from HSCT at 1 year was 80% (95% CI: 50-93). Four patients died, three unrelated to CMV infection and one due to CMV pneumonia. CMVIG as salvage therapy was well tolerated, and no infusion-related adverse events were observed. Competing Interests: The authors declare that this study received support from Biotest. The funder was not involved in the study design, collection, analysis, interpretation of data, the writing of this article, or the decision to submit it for publication. (© 2023 Panesso, Uría, Renedo, Esperalba, Benítez-Carabante, Mendoza-Palomar, Alonso, Oliveras and Diaz-de-Heredia.) |
| References: | Biol Blood Marrow Transplant. 2018 Oct;24(10):2101-2109. (PMID: 29777868) Bone Marrow Transplant. 2018 Oct;53(10):1328-1335. (PMID: 29654288) J Pediatric Infect Dis Soc. 2021 Oct 27;10(9):910-918. (PMID: 34213545) J Infect Dis. 2017 Nov 15;216(8):945-956. (PMID: 29029297) Blood. 2009 Jun 4;113(23):5711-9. (PMID: 19299333) Curr Treat Options Infect Dis. 2021;13(3):123-140. (PMID: 34305463) Transplantation. 2016 Mar;100 Suppl 3:S11-8. (PMID: 26900990) Drugs. 2018 Jul;78(11):1085-1103. (PMID: 29961185) Vox Sang. 2015 Jul;109(1):71-8. (PMID: 25766313) Clin Infect Dis. 2009 Jul 15;49(2):233-40. (PMID: 19522651) Pharmacotherapy. 2010 Jun;30(6):554-61. (PMID: 20500045) Biologicals. 1996 Jun;24(2):117-24. (PMID: 8889058) Mediterr J Hematol Infect Dis. 2019 Sep 01;11(1):e2019048. (PMID: 31528314) Clin Microbiol Rev. 2009 Jan;22(1):76-98, Table of Contents. (PMID: 19136435) Blood. 2002 Nov 15;100(10):3690-7. (PMID: 12393402) J Clin Oncol. 2017 Nov 1;35(31):3547-3557. (PMID: 28783452) Am J Transplant. 2019 Sep;19(9):2479-2494. (PMID: 31247126) J Immunother. 2012 Apr;35(3):293-8. (PMID: 22421947) Clin Infect Dis. 2022 Sep 10;75(4):690-701. (PMID: 34864943) Anticancer Res. 2017 Dec;37(12):6551-6556. (PMID: 29187429) J Pediatr Hematol Oncol. 2023 Jan 1;45(1):e82-e86. (PMID: 36162011) |
| فهرسة مساهمة: | Keywords: CMV hyperimmune globulin; children; cytomegalovirus; hematopoietic stem cell transplantation; salvage therapy |
| تواريخ الأحداث: | Date Created: 20230809 Latest Revision: 20230810 |
| رمز التحديث: | 20240829 |
| مُعرف محوري في PubMed: | PMC10405925 |
| DOI: | 10.3389/fped.2023.1197828 |
| PMID: | 37554153 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2296-2360 |
|---|---|
| DOI: | 10.3389/fped.2023.1197828 |